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1. Identification of a Notch transcriptomic signature for breast cancer

   Background

   Dysregulated Notch signalling contributes to breast cancer development and progression, but validated tools to measure the level of Notch...

   Eike-Benjamin Braune, Felix Geist, ... Urban Lendahl in Breast Cancer Research

   Article Open access 03 January 2024
   

2. Examining the contribution of Notch signaling to lung disease development

   Notch pathway is a widely observed signaling system that holds pivotal functions in regulating various developmental cellular functions and...

   Samar A. Antar, Mohamed Kh. ElMahdy, Ahmed G. Darwish in Naunyn-Schmiedeberg's Archives of Pharmacology

   Article 23 April 2024
   

3. Notch Cell Signaling Pathway and Brain Tumors

   The Notch signaling pathway is highly conserved in most organisms (Artavanis-Tsakonas et al. 1999). There are four different types of Notch receptors...

   Mehdi Hayat Shahi in Role of Signaling Pathways in Brain Tumorigenesis

   Chapter 2023
   

4. Histone methyltransferase SETD1A interacts with notch and promotes notch transactivation to augment ovarian cancer development

   Background

   High expression of SETD1A, a histone methyltransferase that specifically methylates H3K4, acted as a key oncogene in several human cancers....

   Hongjuan Chai, Chunpeng Pan, ... Jugang Wu in BMC Cancer

   Article Open access 27 January 2023
   

5. Diffuse subtype-specific gastric carcinogenesis associated with dysregulation of Notch signaling pathways

   Gastric tumors are the third leading cause of cancer-related mortality worldwide. This study investigates the effects of Notch signaling pathway...

   Karthik Balakrishnan in Genome Instability & Disease

   Article 14 June 2024
   

6. Endothelial Brg1 fine-tunes Notch signaling during zebrafish heart regeneration

   Myocardial Brg1 is essential for heart regeneration in zebrafish, but it remains unknown whether and how endothelial Brg1 plays a role in heart...

   Chenglu **ao, Junjie Hou, ... **g-Wei **ong in npj Regenerative Medicine

   Article Open access 07 April 2023
   

7. Notch ligands are biomarkers of anti-TNF response in RA patients

   Notch and its ligands play a critical role in rheumatoid arthritis (RA) pathogenesis. Hence, studies were conducted to delineate the functional...

   Stephanie R. Zack, Anja Meyer, ... Shiva Shahrara in Angiogenesis

   Article 05 October 2023
   

8. Tanshinol ameliorates imiquimod-induced psoriasis by inhibiting M1 macrophage polarization through suppression of the notch signaling pathway

   Background

   Psoriasis is a common immune-related chronic inflammatory skin disease, often accompanied by significant itching, and once diseased, the...

   Junhao Liu, Shuangshuang Yong, ... Jie Chen in Naunyn-Schmiedeberg's Archives of Pharmacology

   Article Open access 04 June 2024
   

9. Oxidative Stress and Notch Signaling

   Both Notch signaling and oxidative stress have pivotal roles in health and diseases. Emerging evidences indicate that they both can regulate each...

   Vivek Kumar, Mohit Vashishta, Bilikere S. Dwarakanath in Handbook of Oxidative Stress in Cancer: Mechanistic Aspects

   Reference work entry 2022
   

10. TGFBI remodels adipose metabolism by regulating the Notch-1 signaling pathway

    Extracellular matrix proteins are associated with metabolically healthy adipose tissue and regulate inflammation, fibrosis, angiogenesis, and...

    Seul Gi Lee, Jongbeom Chae, ... Ju-Ock Nam in Experimental & Molecular Medicine

    Article Open access 01 March 2023
    

11. The Notch pathway regulates autophagy after hypoxic–ischemic injury and affects synaptic plasticity

    Following neonatal hypoxic–ischemia (HI) injury, it is crucial factor to reconstruct neural circuit and maintain neural network homeostasis for...

    Kexin Li, Meng Lu, ... Yang Zheng in Brain Structure and Function

    Article 21 April 2023
    

12. Knockdown of Notch Suppresses Epithelial-mesenchymal Transition and Induces Angiogenesis in Oral Submucous Fibrosis by Regulating TGF-β1

    Oral submucous fibrosis (OSF) is a chronic disorder with a high malignant transformation rate. Epithelial-mesenchymal transition (EMT) and...

    **rong Wang, Liyan Yang, ... Wen Luo in Biochemical Genetics

    Article 01 August 2023
    

13. The role of Hedgehog and Notch signaling pathway in cancer

    Notch and Hedgehog signaling are involved in cancer biology and pathology, including the maintenance of tumor cell proliferation, cancer stem-like...

    Ruolan **a, Maosen Xu, ... Xuelei Ma in Molecular Biomedicine

    Article Open access 15 December 2022
    

14. Temporal regulation of notch activation improves arteriovenous fistula maturation

    Background

    Arteriovenous fistula (AVF) maturation is a process involving remodeling of venous arm of the AVFs. It is a challenge to balance adaptive...

    Qunying Guo, Guang Chen, ... Jizhong Cheng in Journal of Translational Medicine

    Article Open access 23 November 2022
    

15. Chromatin accessibility analysis suggested vascular induction of the biliary epithelium via the Notch signaling pathway in the human liver

    The biliary epithelial cells (cholangiocytes) in the liver originate from undifferentiated liver parenchymal cells (hepatoblasts) that are located...

    Masaharu Yoshihara, Takahiro Nakayama, Satoru Takahashi in BMC Research Notes

    Article Open access 21 December 2023
    

16. Hsa_circRNA_102051 regulates colorectal cancer proliferation and metastasis by mediating Notch pathway

    Background

    The purpose of this study was to investigate the role of hsa_circRNA_102051 in colorectal cancer (CRC) and its effect on the stemness of...

    Zhongsheng Chen, Haiyu Cheng, ... Wei Zhan in Cancer Cell International

    Article Open access 05 October 2023
    

17. Krüppel-like factor 10 modulates stem cell phenotypes of pancreatic adenocarcinoma by transcriptionally regulating notch receptors

    Background

    Pancreatic adenocarcinoma (PDAC) is well known for its rapid distant metastasis and local destructive behavior. Loss of Krüppel-like factor...

    Yi-Chih Tsai, Kung Hung Cheng, ... Hui-Ju Ch’ang in Journal of Biomedical Science

    Article Open access 12 June 2023
    

18. Ubiquilin-4 induces immune escape in gastric cancer by activating the notch signaling pathway

    Purpose

    We aimed to investigate the role of ubiquilin-4 in predicting the immunotherapy response in gastric cancer.

    Methods

    Retrospective...

    Quan Jiang, Hao Chen, ... Yihong Sun in Cellular Oncology

    Article 13 September 2023
    

19. Notch signaling pathway: a comprehensive prognostic and gene expression profile analysis in breast cancer

    Breast cancer is a complex disease exhibiting a great degree of heterogeneity due to different molecular subtypes. Notch signaling regulates the...

    Hassan Yousefi, Afshin Bahramy, ... Sadegh Babashah in BMC Cancer

    Article Open access 07 December 2022
    

20. Notch-associated lncRNAs profiling circuiting epigenetic modification in colorectal cancer

    Background

    Colorectal cancer (CRC) is one of the most prevalent digestive cancers, ranking the 2nd cause of cancer-related fatality worldwide. The...

    Omnia Emam, Eman F. Wasfey, Nadia M. Hamdy in Cancer Cell International

    Article Open access 13 October 2022