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SARS-CoV-2: analysis of the effects of mutations in non-structural proteins
A worldwide pandemic that started in China in late 2019 was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a single-stranded...
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Global landscape of SARS-CoV-2 mutations and conserved regions
BackgroundAt the end of December 2019, a novel strain of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) disease (COVID-19) has been...
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SARS-CoV-2 viral protein Nsp2 stimulates translation under normal and hypoxic conditions
When viruses like SARS-CoV-2 infect cells, they reprogram the repertoire of cellular and viral transcripts that are being translated to optimize...
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LINC01002 functions as a ceRNA to regulate FRMD8 by sponging miR-4324 for the development of COVID-19
BackgroundSyndrome coronavirus-2 (SARS-CoV-2) has developed various strategies to evade the antiviral impact of type I IFN. Non-structural proteins...
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A Molecular Biomarker-Based Triage Approach for Targeted Treatment of Post-COVID-19 Syndrome Patients with Persistent Neurological or Neuropsychiatric Symptoms
Approximately 30% of COVID-19 cases may experience chronic symptoms, known as post-COVID-19 syndrome (PCS). Common PCS symptoms can include fatigue,...
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Exploring the pharmacological aspects of natural phytochemicals against SARS-CoV-2 Nsp14 through an in silico approach
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), possesses an important bifunctional nonstructural protein (nsp14) with a C-terminal...
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Protein-based antigen presentation platforms for nanoparticle vaccines
Modern vaccine design has sought a minimalization approach, moving to the isolation of antigens from pathogens that invoke a strong neutralizing...
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Computational Drug Repurposing for the Development of Drugs Against Coronaviruses
Coronaviruses are single-stranded positive-sense RNA viruses possessing unique replication machinery, which consists of non-structural proteins...
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Insights into In Silico Methods to Explore Plant Bioactive Substances in Combating SARS-CoV-2
SARS-CoV-2 is a virus belonging to the species “severe acute respiratory syndrome-related coronavirus” (SARSr-CoV), a strain that causes the...
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Exploring nucleoside analogs: key targets in the viral life cycle - advancing strategies against SARS-CoV-2
The COVID-19 pandemic has been a major reason behind the increased research aimed at the identification of effective antiviral agents. Among these,...
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Moringa oleifera and Its Biochemical Compounds: Potential Multi-targeted Therapeutic Agents Against COVID-19 and Associated Cancer Progression
The Coronavirus disease-2019 (COVID-19) pandemic is a global concern, with updated pharmacological therapeutic strategies needed. Cancer patients...
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SARS-CoV-2 outbreak: role of viral proteins and genomic diversity in virus infection and COVID-19 progression
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is the cause of coronavirus disease 2019 (COVID-19); a severe respiratory...
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Identification of G-quadruplex DNA sequences in SARS-CoV2
G-quadruplex structure or Putative Quadruplex Sequences (PQSs) are abundant in human, microbial, DNA, or RNA viral genomes. These sequences in RNA...
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Whole-genome sequencing and genetic characteristics of representative porcine reproductive and respiratory syndrome virus (PRRSV) isolates in Korea
BackgroundPorcine reproductive and respiratory syndrome virus (PRRSV) is a macrophage-tropic arterivirus with extremely high genetic and pathogenic...
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Exosome-mediated regulation of inflammatory pathway during respiratory viral disease
Viruses have developed many mechanisms by which they can stimulate or inhibit inflammation and cause various diseases, including viral respiratory...
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Structure genomics of SARS-CoV-2 and its Omicron variant: drug design templates for COVID-19
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has brought an unprecedented public...
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Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
Ten years after the severe SARS-CoV outbreak in 2002, another lethal coronavirus outbreak was reported in Middle Eastern countries. Based on the...
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Structural basis for the multimerization of nonstructural protein nsp9 from SARS-CoV-2
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of a potentially fatal disease named coronavirus disease 2019...
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Therapeutic strategies for COVID-19: progress and lessons learned
The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous efforts to develop therapeutic strategies that target severe acute...
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Evidence of natural selection and dominance of SARS-CoV-2 variant Lambda (C.37) over variants of concern in Cusco, Peru
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineage C.37 (Lambda) has spread rapidly in Peru and other Latin American countries....
