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Activation of NOP receptor increases vulnerability to stress: role of glucocorticoids and CRF signaling
RationaleRecently, we demonstrated that the activation of the nociceptin/orphanin FQ (N/OFQ) receptor (NOP) signaling facilitates depressive-like...
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N/OFQ modulates orofacial pain induced by tooth movement through CGRP-dependent pathways
BackgroundNociceptin/orphanin FQ (N/OFQ) has been revealed to play bidirectional roles in orofacial pain modulation. Calcitonin gene-related peptide...
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Involvement of the nociceptin opioid peptide receptor in morphine-induced antinociception, tolerance and physical dependence in female mice
Nociceptin opioid peptide (NOP) receptor modulates pain transmission and is considered a prospective target for pain management. Under acute pain...
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Structure-Based SAR in the Design of Selective or Bifunctional Nociceptin (NOP) Receptor Agonists
The nociceptin opioid receptor (NOP), the fourth member of the opioid receptor family, and its endogenous peptide ligand, nociceptin or orphanin FQ...
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Exacerbated Headache-Related Pain in the Single Prolonged Stress Preclinical Model of Post-traumatic Stress Disorder
Chronic headache pain is one of the most commonly reported comorbid pain conditions with post-traumatic stress disorder (PTSD) patients and resistant...
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Regulation of N-type calcium channels by nociceptin receptors and its possible role in neurological disorders
Activation of nociceptin opioid peptide receptors (NOP, a.k.a. opioid-like receptor-1, ORL-1) by the ligand nociceptin/orphanin FQ, leads to G...
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Effects of Non-Opiate Analogue of Leu-Enkephalin on the Ion Currents, Number of Nucleoli, and p53 Expression in Isolated Cardiomyocytes of Albino Rats
Acute exposure of isolated ventricular cardiomyocytes to non-opiate analogue of leu-enkephalin (NALE peptide: Phe-D-Ala-Gly-Phe-Leu-Arg) in a...
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Evolution and challenges of opioids in pain management: Understanding mechanisms and exploring strategies for safer analgesics
Opioids traced back to ancient civilizations, have evolved in their usage for acute and chronic pain treatment. Their interaction with the endogenous...
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Interactions Between Endogenous Opioids and the Immune System
The endogenous opioid system, which consists of opioid receptors and their ligands, is widely expressed in the nervous system and also found in the...
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Opioid Peptides and Their Receptors
Since the discovery of opioid receptors and their endogenous ligands named opioid peptides, it has been established that opiates exert their effects...
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Opioid Peptides and Their Receptors
Since the discovery of opioid receptors and their endogenous ligands named opioid peptides, it has been established that opiates exert their effects...
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Opioid Receptors and Neuronal Signal Transduction
This chapter provides information on the classification, structure, and properties of the main opioidOpioids receptor subtypes, their canonical and...
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Nociceptin/orphanin FQ modulates energy homeostasis through inhibition of neurotransmission at VMN SF-1/ARC POMC synapses in a sex- and diet-dependent manner
BackgroundOrphanin FQ (aka nociceptin; N/OFQ) binds to its nociceptin opioid peptide (NOP) receptor expressed in proopiomelanocortin (POMC) neurons...
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N/OFQ-NOP System and Airways
Asthma is a heterogeneous chronic inflammatory disease of the airways. The most prevalent form is atopic asthma, which is initiated by the exposure...
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N/OFQ-NOP System in Food Intake
While lifestyle modifications should be the first-line actions in preventing and treating obesity and eating disorders, pharmacotherapy also provides...
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Impact of a History of Caloric Restriction and a Frustration Stress Manipulation on Binge-Like Eating Behavior in Female Rats: Preclinical Results
Medications, at present, play a limited role on eating disorders. Currently, only two drugs were approved by the Food and Drug Administration,...
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Neurobiological Mechanism of Acupuncture Analgesia in Chronic Somatic Pain
Acupuncture reduces pain by activating specific areas called acupoints on the patient’s body. When these acupoints are fully activated, sensations of...
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Opioids and Opiates: Pharmacology, Abuse, and Addiction
This chapter presents an overview of the opioid system consisting of a wide variety of endogenous and exogenous ligands, as well as several receptor...
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NOP Receptor Signaling Cascades
The nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor is a G protein-coupled receptor with wide distribution throughout the peripheral and...