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Smoking Abstinence and Neurocognition: Implications for Cessation and Relapse
In this chapter, we review the last decade of research on the effects of smoking abstinence on various forms of neurocognition, including executive... -
Effects of smoking on D2/D3 striatal receptor availability in alcoholics and social drinkers
Studies have reported lower striatal D 2 /D 3 receptor availability in both alcoholics and cigarette smokers relative to healthy controls. These...
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Anhedonia predicts altered processing of happy faces in abstinent cigarette smokers
RationaleAnhedonia—diminished capacity to experience pleasure—is associated with tobacco dependence and smoking cessation failure. However, the...
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Alcohol-induced increases in smoking behavior for nicotinized and denicotinized cigarettes in men and women
IntroductionAlcohol has been shown to increase smoking urges and smoking behavior. However, alcohol’s effects on specific components of smoking...
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Modeling Alcohol Self-Administration in the Human Laboratory
This review focuses on 27 studies employing experimental alcohol self-administration (ASA) in humans which were published between 1989 and 2010.... -
The insula and drug addiction: an interoceptive view of pleasure, urges, and decision-making
We have recently shown that damage to the insula leads to a profound disruption of addiction to cigarette smoking (Naqvi et al., Science 315:531–534,
2007... -
Naltrexone in Smoking Cessation: A Review of the Literature and Future Directions
There are a number of efficacious pharmacotherapies currently available for smoking cessation, including nicotine replacement, buproprion, and... -
Nicotine effects on affective response in depression-prone smokers
RationaleComorbidity between cigarette smoking and depression is thought to arise because depression-prone smokers self-administer nicotine to...
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Influence of nicotine on positive affect in anhedonic smokers
RationaleThe possibility that individuals administer nicotine to self-regulate persistent negative affect has received interest as a possible...
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Differential effects of nicotine on alcohol consumption in men and women
RationaleNicotine and alcohol are frequently co-used, suggesting that use of one drug may facilitate use of the other. Furthermore, because men and...
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Naltrexone reduces the relative reinforcing value of nicotine in a cigarette smoking choice paradigm
RationaleHuman behavioral pharmacology studies can examine how medications that target different neurotransmitter systems influence different aspects...
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Effects of cigarette nicotine content and smoking pace on subsequent craving and smoking
Abstract
Rationale. The relative contribution of sensory and pharmacological variables in regulating craving and smoking remains unclear. Rapid...
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Sex differences in the subjective and reinforcing effects of cigarette nicotine dose
Abstract
Rationale. Some research with novel nicotine delivery methods suggests that nicotine itself may be less reinforcing in women than in men....
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Naltrexone blockade of nicotine effects in cigarette smokers
Rationale: The role of endogenous opiate systems in cigarette smoking remains unclear. In laboratory animals, opiate antagonists block many of the...