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Behavioral characterization of early nicotine withdrawal in the mouse: a potential model of acute dependence
BackgroundClinical and preclinical research have demonstrated that short-term exposure to nicotine during the initial experimentation stage can lead...
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Liraglutide attenuates nicotine self-administration as well as nicotine seeking and hyperphagia during withdrawal in male and female rats
RationaleNicotine cessation is associated with increased consumption of highly palatable foods and body weight gain in most smokers. Concerns about...
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Biobehavioral and affective stress responses during nicotine withdrawal: Influence of regular cannabis co-use
BackgroundCo-use of cannabis is increasing in nicotine users and presents additional challenges in addressing nicotine dependence. This study...
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The Role of Nicotine Metabolic Rate on Nicotine Dependence and Rewarding: Nicotine Metabolism in Chinese Male Smokers and Male Mice
The exact relationship between nicotine metabolism and dependence is not fully understood but is known to be influenced at a molecular level by...
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Lacidipine Attenuates Symptoms of Nicotine Withdrawal in Mice
Nicotine-withdrawal after daily exposure manifests somatic and affective symptom including a range of cognitive deficits. Earlier studies suggested...
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Effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanolone
BackgroundProgesterone administration has therapeutic effects in tobacco use disorder (TUD), with females benefiting more than males. Conversion of...
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Bidirectional relationship between attentional deficits and escalation of nicotine intake in male rats
RationalePeople with tobacco addiction have deficits in cognition, in particular deficits in attention. It is not clear however, whether deficits are...
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Prenatal Hypoxia Affects Nicotine Consumption and Withdrawal in Adult Rats via Impairment of the Glutamate System in the Brain
The role of damaging factors in the prenatal period as a basis for drug addiction in offspring is of great interest. In this study, we aim at...
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Impact of Adolescent Nicotine Exposure in Pre- and Post-natal Oxycodone Exposed Offspring
Perinatal exposure to prescription opioids pose a critical public health risk. Notably, research has found significant neurodevelopmental and...
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Cannabidiol reduces withdrawal symptoms in nicotine-dependent rats
RationaleCannabidiol (CBD) reduces craving in animal models of alcohol and cocaine use and is known to modulate nicotinic receptor function,...
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Development of pulsed intravenous nicotine infusions as a model for inhaled nicotine in humans
RationaleAlthough nicotine from cigarettes is delivered in puff-sized amounts, most preclinical and human intravenous (IV) nicotine studies have used...
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Anhedonia in Nicotine Dependence
Prior findings indicate that trait anhedonia enhances the likelihood of becoming a tobacco smoker, and preliminary evidence suggests that smoking...
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Nicotine pharmacokinetics and subjective responses after using nicotine pouches with different nicotine levels compared to combustible cigarettes and moist smokeless tobacco in adult tobacco users
RationaleOral tobacco–derived nicotine products include on!® nicotine pouches (NPs) which are tobacco-leaf free and available in multiple flavors and...
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Adult consequences of repeated nicotine and Δ9-tetrahydrocannabinol (THC) vapor inhalation in adolescent rats
RationaleUse of electronic drug delivery systems (EDDS, “e-cigarettes”) to ingest nicotine and Δ 9 -tetrahydrocannabinol (THC) has surged in...
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Novel rapid-acting sublingual nicotine tablet as a cigarette substitution strategy
RationaleCurrent nicotine replacement products provide a much slower onset of nicotine delivery than cigarettes, and hence are only marginally...
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Nicotine Pharmacology, Abuse, and Addiction
Despite increased public awareness of the substantial health risks, tobacco use remains one of the greatest public health concerns around the world....
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Histone Methyltransferase G9a Plays an Essential Role on Nicotine Preference in Zebrafish
Psychostimulants regulate behavioral responses in zebrafish via epigenetic mechanisms. We have previously shown that DNA methylation and histone...
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Microglia sustain anterior cingulate cortex neuronal hyperactivity in nicotine-induced pain
BackgroundLong-term smoking is a risk factor for chronic pain, and chronic nicotine exposure induces pain-like effects in rodents. The anterior...
