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Exploring gene network and protein interaction analysis of neurotrophin signaling pathway in ameloblastoma
Ameloblastoma is a non-cancerous but aggressive oral tumor emerging from odontogenic epithelial tissue involved during odontogenesis. Since there is...
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Neurotrophin signaling is a central mechanism of salivary dysfunction after irradiation that disrupts myoepithelial cells
The mechanisms that prevent regeneration of irradiated (IR) salivary glands remain elusive. Bulk RNAseq of IR versus non-IR human salivary glands...
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Cooperative interactions between neurotrophin receptors and CXCR4 regulate macrophage phenotype and susceptibility to activation by HIV
Neural damage due to inflammatory activation of macrophages and microglia is a consequence of HIV infection that leads to cognitive dysfunction. The...
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The Molecular Pathway of p75 Neurotrophin Receptor (p75NTR) in Parkinson’s Disease: The Way of New Inroads
Parkinson’s disease (PD) is a chronic and progressive neurodegenerative disease of the brain. PD is characterized by motor and non-motor symptoms....
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Neurotrophin-3 Enhances the Effectiveness of Cell Therapy in Chronic Spinal Cord Injuries
Neurotrophin-3 enhances the effectiveness of human olfactory ensheathing cells in improving hind limb mobility in rats with post-traumatic cysts of...
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Genetic and Pharmacological Modulation of P75 Neurotrophin Receptor Attenuate Brain Damage After Ischemic Stroke in Mice
The precursor nerve growth factor (ProNGF) and its receptor p75 neurotrophin receptor (p75 NTR ) are upregulated in several brain diseases, including...
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p75 neurotrophin receptor modulation in mild to moderate Alzheimer disease: a randomized, placebo-controlled phase 2a trial
p75 neurotrophin receptor (p75 NTR ) signaling pathways substantially overlap with degenerative networks active in Alzheimer disease (AD). Modulation...
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Suppression of HIV-associated Macrophage Activation by a p75 Neurotrophin Receptor Ligand
Previous studies indicated that nerve growth factor (NGF) and proNGF differentially regulate the phenotype of macrophages and microglia via actions...
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P75 neurotrophin receptor controls subventricular zone neural stem cell migration after stroke
Stroke is the leading cause of adult disability. Endogenous neural stem/progenitor cells (NSPCs) originating from the subventricular zone (SVZ)...
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Neurotrophin-3 promotes peripheral nerve regeneration by maintaining a repair state of Schwann cells after chronic denervation via the TrkC/ERK/c-Jun pathway
BackgroundMaintaining the repair phenotype of denervated Schwann cells in the injured distal nerve is crucial for promoting peripheral nerve...
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Paroxetine Effect on Nerve Growth Factor, Human Neurotrophin-4, Brain-Derived Neurotrophic Factor Levels in Post-stroke Depression
The aim of this study is to explore paroxetine’s effect on nerve growth factor (NGF), human neurotrophin-4 (NT-4), and brain-derived neurotrophic...
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Nerve Growth Factor: The First Molecule of the Neurotrophin Family
Neurotrophins (NTs) are molecules regulating differentiation, maintenance, and functional plasticity of vertebrate nervous systems. Nerve growth...
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Genetic interplay between transcription factor Pou4f1/Brn3a and neurotrophin receptor Ret in retinal ganglion cell type specification
BackgroundWhile the transcriptional code governing retinal ganglion cell (RGC) type specification begins to be understood, its interplay with...
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Neuroplastic Changes in Rat Hippocampus after Ischemic Stroke in the Neocortex: The Involvement of the Hypothalamic-Pituitary-Adrenal Axis System and the Neurotrophin System
Abstract —Middle cerebral artery occlusion (MCAO) is the cause of most ischemic strokes, resulting in focal brain damage affecting not only various...
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Neurotrophins and Phytochemicals: Potential Partners to Combat Neurodegenerative Diseases
Neurotrophins and phytochemicals have emerged as promising areas of research in the field of neuroscience and human health. Neurotrophins are a group...
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Improved neurocognitive performance in FIV infected cats following treatment with the p75 neurotrophin receptor ligand LM11A-31
HIV rapidly infects the central nervous system (CNS) and establishes a persistent viral reservoir within microglia, perivascular macrophages and...
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Neurotrophin signalling in amygdala-dependent cued fear learning
The amygdala is a central hub for fear learning assessed by Pavlovian fear conditioning. Indeed, the prevailing hypothesis that learning and memory...
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Neurotrophin Regulation and Signaling in Airway Smooth Muscle
Structural and functional aspects of bronchial airways are key throughout life and play critical roles in diseases such as asthma. Asthma involves...
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Astrocytes in Post-Stroke Depression: Roles in Inflammation, Neurotransmission, and Neurotrophin Signaling
Post-stroke depression (PSD) is a frequent and disabling complication of stroke that affects up to one-third of stroke survivors. The pathophysiology...
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Features of Remyelination after Transplantation of Olfactory Ensheathing Cells with Neurotrophic Factors into Spinal Cord Cysts
This paper shows for the first time that co-transplantation of human olfactory ensheathing cells with neurotrophin-3 into spinal cord cysts is more...