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Oestradiol as a neuromodulator of learning and memory
Although hormones such as glucocorticoids have been broadly accepted in recent decades as general neuromodulators of memory processes, sex steroid...
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Histamine: A Key Neuromodulator of Memory Consolidation and Retrieval
In pharmacological studies conducted on animals over the last four decades, histamine was determined to be a strong modulator of learning and memory....
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Modeling Emergent Dynamics Arising from Synaptic Tagging and Capture at the Network Level
The transfer from short-term memory, which persists only for a few hours, to long-term memory is assumed to begin with a process called synaptic...
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Dynamic network impairments underlie cognitive fluctuations in Lewy body dementia
Cognitive fluctuations are a characteristic and distressing disturbance of attention and consciousness seen in patients with Dementia with Lewy...
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Genetically Encoded Biosensors Reveal Spatiotemporal Dynamics and Cellular Heterogeneity of Neuronal Cells
Neuronal networks are among the most fascinating, yet complex, systems within biology. From neurotransmitter and neuromodulator signaling to...
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Where Top-Down Meets Bottom-Up: Cell-Type Specific Connectivity Map of the Whisker System
Sensorimotor computation integrates bottom-up world state information with top-down knowledge and task goals to form action plans. In the rodent...
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Guanosine modulates K+ membrane currents in SH-SY5Y cells: involvement of adenosine receptors
Guanosine (GUO), widely considered a key signaling mediator, is implicated in the regulation of several cellular processes. While its interaction...
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Serotonin disruption at gestation alters expression of genes associated with serotonin synthesis and reuptake at weaning
RationaleSerotonin (5-HT) is a monoamine neuromodulator that plays a key role in the organization of the central nervous system. 5-HT alterations may...
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Sphingosine 1-Phoshpate Receptors are Located in Synapses and Control Spontaneous Activity of Mouse Neurons in Culture
Sphingosine-1-phosphate (S1P) is best known for its roles as vascular and immune regulator. Besides, it is also present in the central nervous system...
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Dopamine and Synaptic Tagging and Capture: A Neuromodulatory Interplay That Shapes Associative Plasticity
Dopamine is a neurotransmitter that plays a crucial role in regulating diverse functions, such as motor control, mood, sleep, attention, reward...
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Opposing actions of CRF-R1 and CB1 receptor on facial stimulation-induced MLI-PC plasticity in mouse cerebellar cortex
BackgroundCorticotropin-releasing factor (CRF) is the major neuromodulator orchestrating the stress response, and is secreted by neurons in various...
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Neurobiological Factors of Executive Dysfunction in Autism Spectrum Disorders
Autism is a developmental disorder characterized by difficulties in social interaction and a tendency to stereotypical behavior. Neuropsychological...
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Neurobehavioral protective effects of Japanese sake yeast supplement against chronic stress-induced anxiety and depression-like symptoms in mice: Possible role of central adenosine receptors
RationaleUsing routine synthetic drugs in the treatment of psychiatric disorders may have some restrictions due to serious side effects and...
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Spatial and temporal scales of dopamine transmission
Dopamine is a prototypical neuromodulator that controls circuit function through G protein-coupled receptor signalling. Neuromodulators are volume...
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Context-dependent representations of movement in Drosophila dopaminergic reinforcement pathways
Dopamine plays a central role in motivating and modifying behavior, serving to invigorate current behavioral performance and guide future actions...
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Developmental Changes in Early Sharp Waves in the Hippocampus of Neonatal Rats
Synchronized activity the hallmark of neural networks. Early sharp waves (eSPW) form one type of synchronized activity – these are synchronized...
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Effect of Taurine on the Manifestations of Audiogenic Epilepsy in Rats with Pendulum Movements
Decreased hippocampal taurine levels were demonstrated in a rat strain predisposed to audiogenic epilepsy and displaying pendulum movements (PM)....
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