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Liquid Biopsy in Adverse Neurodevelopment of Children: Problems and Prospects
Neurodevelopmental disorders in children have an important impact on the quality of life in the whole life cycle. Severe neurodevelopmental disorders...
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Isavuconazole Induces Neurodevelopment Defects and Motor Behaviour Impairment in Zebrafish Larvae
Isavuconazole is a broad-spectrum antifungal drug used for the treatment of serious infections caused by invasive aspergillosis and mucormycosis in...
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Molecular Mechanisms Involved in the Regulation of Neurodevelopment by miR-124
miR-124 is a miRNA predominantly expressed in the nervous system and accounts for more than a quarter of the total miRNAs in the brain. It regulates...
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The Effects of Early Childhood Malnutrition on Neurodevelopment
It is estimated that undernutrition affected more than 191 million children under the age of 5 in 2019. Early childhood malnutrition impacts health...
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Environmental Metal Exposure, Neurodevelopment, and the Role of Iron Status: a Review
Purpose of ReviewExposure to environmental metals, like lead (Pb), manganese (Mn), and methylmercury (Me-Hg), has consistently been implicated in...
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Disproportionate Expression of ATM in Cerebellar Cortex During Human Neurodevelopment
Cerebellar neurodegeneration is a classical feature of ataxia telangiectasia (A-T), an autosomal recessive condition caused by loss-of-function...
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Maternal SARS-CoV-2 impacts fetal placental macrophage programs and placenta-derived microglial models of neurodevelopment
BackgroundThe SARS-CoV-2 virus activates maternal and placental immune responses. Such activation in the setting of other infections during pregnancy...
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Stress-Sensitive Regulators of Fetal Neurodevelopment in HIV and Preeclampsia: An Immunocytochemical Appraisal of Placental OGT and T4 Levels
Preeclampsia and HIV are a significant burden to maternal health globally, especially in low-middle income countries such as South Africa. In the...
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Dolutegravir Inhibition of Matrix Metalloproteinases Affects Mouse Neurodevelopment
Dolutegravir (DTG) is a first-line antiretroviral drug (ARV) used in combination therapy for the treatment of human immunodeficiency virus type-1...
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Prenatal depression exposure alters white matter integrity and neurodevelopment in early childhood
Prenatal exposure to maternal depression increases the risk for onset of emotional and behavioral disorders in children. We investigated the effects...
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Role of circRNAs in neurodevelopment and neurodegenerative diseases
With the rapid development of sequencing technology, scientists have been able to study and acquire a better understanding of non-coding RNAs...
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CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment
CLEC16A is a membrane-associated C-type lectin protein that functions as a E3-ubiquitin ligase. CLEC16A regulates autophagy and mitophagy, and...
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Impact of glyphosate-based herbicide exposure through maternal milk on offspring’s antioxidant status, neurodevelopment, and behavior
Glyphosate-based Herbicide (GBH) is a widely used pesticide that functions as a broad-spectrum, non-selective herbicide. Despite advanced research to...
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Microglia: A Critical Cell for Neurodevelopment
The temporal and spatial pattern of microglia colonization of the nervous system implies a role in neurovascularization, cell fate differentiation to...
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The Role of KDM2A and H3K36me2 Demethylation in Modulating MAPK Signaling During Neurodevelopment
Intellectual disability (ID) is a condition characterized by cognitive impairment and difficulties in adaptive functioning. In our research, we...
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Human Breast Milk Omics and Neurodevelopment
Breast milk is the ideal food for the premature and mature babies and has undoubtedly immediate and ultimate benefits. Among other things, it...
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Maternal folic acid impacts DNA methylation profile in male rat offspring implicated in neurodevelopment and learning/memory abilities
BackgroundPericonceptional folic acid (FA) supplementation not only reduces the incidence of neural tube defects, but also improves cognitive...
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Fetal cranial growth trajectories are associated with growth and neurodevelopment at 2 years of age: INTERBIO-21st Fetal Study
Many observational studies and some randomized trials demonstrate how fetal growth can be influenced by environmental insults (for example, maternal...
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Metabolic Flexibility Assists Reprograming of Central and Peripheral Innate Immunity During Neurodevelopment
Central innate immunity assists time-dependent neurodevelopment by recruiting and interacting with peripheral immune cells. Microglia are the major...
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Probiotics ameliorates LPS induced neuroinflammation injury on Aβ 1–42, APP, γ-β secretase and BDNF levels in maternal gut microbiota and fetal neurodevelopment processes
The gut microbiota influences brain development and functioning through the gut-brain axis. This is first study regulate maternal gut microbiota and...
