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Epilepsy and Neurodegeneration
Epilepsy is a neurological condition that impacts close to 65 million people around the world, thus exhibiting a substantial global disease burden....
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Neuroimaging of tissue microstructure as a marker of neurodegeneration in the AT(N) framework: defining abnormal neurodegeneration and improving prediction of clinical status
BackgroundAlzheimer’s disease involves accumulating amyloid (A) and tau (T) pathology, and progressive neurodegeneration (N), leading to the...
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E-Health and Neurodegeneration
The increasing prevalence of neurodegenerative diseases consists of main challenges for healthcare systems. Patients with neurodegeneration diseases...
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Handbook of Computational Neurodegeneration
The Handbook of Computational Neurodegeneration provides a comprehensive overview of the field and thus bridges the gap between standard textbooks of...
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Role of Amyloid Beta in Neurodegeneration and Therapeutic Strategies for Neuroprotection
The gradual loss of neurons’ structure and function in the central nervous system is known as neurodegeneration. It is a defining feature of several...
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Microglial inhibition alleviates alpha-synuclein propagation and neurodegeneration in Parkinson’s disease mouse model
The accumulation of alpha-synuclein (αSyn) is widely recognized as the main pathological process in Parkinson’s disease (PD). Additionally,...
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Calpain Mediated Neurodegeneration in Parkinson’s disease
AbstractParkinson’s disease (PD), a neurodegenerative movement disorder, is clinically manifested by disturbances in motor functions and non-motor...
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Markers of Neurodegeneration in Parkinson’s Disease
Abstract —This review describes the role of peripheral blood biomarkers involved in neurodegeneration and neuroregeneration in Parkinson’s disease:...
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Regulatory T cells limit age-associated retinal inflammation and neurodegeneration
BackgroundAgeing is the principal risk factor for retinal degenerative diseases, which are the commonest cause of blindness in the developed...
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Serum neurofilament indicates accelerated neurodegeneration and predicts mortality in late-stage Parkinson’s disease
Different stages of Parkinson’s disease (PD) are defined by clinical criteria, while late-stage PD is marked by the onset of morbidity milestones and...
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Molecular Mechanisms Associated with Neurodegeneration of Neurotropic Viral Infection
Viral infections of the central nervous system (CNS) cause variable outcomes from acute to severe neurological sequelae with increased morbidity and...
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Circadian disruption and sleep disorders in neurodegeneration
Disruptions of circadian rhythms and sleep cycles are common among neurodegenerative diseases and can occur at multiple levels. Accumulating evidence...
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Applying Joint Graph Embedding to Study Alzheimer’s Neurodegeneration Patterns in Volumetric Data
Neurodegeneration measured through volumetry in MRI is recognized as a potential Alzheimer’s Disease (AD) biomarker, but its utility is limited by...
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IFNγ drives neuroinflammation, demyelination, and neurodegeneration in a mouse model of multiple system atrophy
Multiple system atrophy (MSA) is a rare and fatal synucleinopathy characterized by insoluble alpha-synuclein (α-syn) cytoplasmic inclusions located...
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Glia Connect Inflammation and Neurodegeneration in Multiple Sclerosis
Multiple sclerosis (MS) is regarded as a chronic inflammatory disease that leads to demyelination and eventually to neurodegeneration. Activation of...
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Visualizing Neurodegeneration Using Atomic Force Microscopy
Neurodegeneration can be described as a progressive damage and eventually death of neuronal cells, affecting the proper function of the whole of the...
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Complement C3 Enhances LPS-Elicited Neuroinflammation and Neurodegeneration Via the Mac1/NOX2 Pathway
Recent studies showed increased expression of complements in various neurodegenerative diseases, including Alzheimer’s and Parkinson’s diseases....
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Multiple Mechanisms of the Therapeutic Effect of Trehalose in Inhibition of Experimental Neurodegeneration
AbstractThe search for effective treatment for neurodegeneration implies attacking the multiple mechanisms of this pathology. Such properties were...
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Involvement of Proteasomal and Endoplasmic Reticulum Stress in Neurodegeneration After Global Brain Ischemia
A brief period of transient global brain ischemia leads to selective ischemic neurodegeneration associated with death of hippocampal CA1 pyramidal...
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Emerging Role of Long Noncoding RNAs in Regulating Inflammasome-Mediated Neurodegeneration in Parkinson’s Disease
Parkinson’s disease (PD) is one of the complex neurodegenerative disorders, primarily characterized by motor deficits, including bradykinesia,...
