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Peripheral Nerve Regeneration
The nerve chamber model has dominated the experimental study of peripheral nerve (PN) regeneration with animal models as well as in several clinical...
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Nerve Regeneration
Nerve injuries may result in neurological dysfunction or even permanent disability, which poses various challenges to physicians. In the peripheral...
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Spontaneous Regeneration after Hypoglossal Nerve Injury with Long Nerve Resection in Rats
Spontaneous neural regeneration may occur in peripheral nerve injury after nerve resection with a relatively short gap, whereas regeneration does not...
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Enhanced peripheral nerve regeneration by mechano-electrical stimulation
To address limitations in current approaches for treating large peripheral nerve defects, the presented study evaluated the feasibility of functional...
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Novel artificial nerve transplantation of human iPSC-derived neurite bundles enhanced nerve regeneration after peripheral nerve injury
BackgroundSevere peripheral nerve damage always requires surgical treatment. Autologous nerve transplantation is a standard treatment, but it is not...
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Assaying Optic Nerve Regeneration in Larval Zebrafish
Zebrafish have a remarkable capacity for spontaneously regenerating their central nervous system. Larval zebrafish are optically transparent and...
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The Pulsed Nd:YAG Laser Therapy Enhanced Nerve Regeneration via Apoptosis Inhibition in a Rat Crushed Sciatic Nerve Model
The study was aimed to validate the efficacy of the pulsed Nd:YAG laser on nerve regeneration in a rat sciatic nerve crushed model. 54 Wistar rats...
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Neither injury induced macrophages within the nerve, nor the environment created by Wallerian degeneration is necessary for enhanced in vivo axon regeneration after peripheral nerve injury
BackgroundSince the 1990s, evidence has accumulated that macrophages promote peripheral nerve regeneration and are required for enhancing...
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Micropattern-based nerve guidance conduit with hundreds of microchannels and stem cell recruitment for nerve regeneration
Guiding the regrowth of thousands of nerve fibers within a regeneration-friendly environment enhances the regeneration capacity in the case of...
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Nerve Regeneration Through Differentiation of Endometrial-Derived Mesenchymal Stem Cells into Nerve-Like Cells Using Polyacrylonitrile/Chitosan Conduit and Berberine in a Rat Sciatic Nerve Injury Model
Nervous injuries are common in humans. One of the most advanced treatment methods is neural tissue engineering. This research aims to utilize...
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DOK7 Promotes NMJ Regeneration After Nerve Injury
Motor function recovery from injury requires the regeneration of not only muscle fibers, but also the neuromuscular junction—the synapse between...
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Electroacupuncture Promotes Nerve Regeneration and Functional Recovery Through Regulating lncRNA GAS5 Targeting miR-21 After Sciatic Nerve Injury
Although the benefits of electroacupuncture (EA) for peripheral nerve injury (PNI) are well accepted in clinical practice, the underlying mechanism...
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Transcription Factor BCL11A Regulates Schwann Cell Behavior During Peripheral Nerve Regeneration
Nerve injury-induced Schwann cell dedifferentiation helps to construct a favorable microenvironment for axon growth. Transcription factors regulate...
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Epithelial plasticity enhances regeneration of committed taste receptor cells following nerve injury
Taste receptor cells are taste bud epithelial cells that are dependent upon the innervating nerve for continuous renewal and are maintained by...
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Transcriptional Control of Peripheral Nerve Regeneration
Transcription factors are master regulators of various cellular processes under diverse physiological and pathological conditions. Many transcription...
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Regeneration of starfish radial nerve cord restores animal mobility and unveils a new coelomocyte population
The potential to regenerate a damaged body part is expressed to a different extent in animals. Echinoderms, in particular starfish, are known for...
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Longitudinally aligned inner-patterned silk fibroin conduits for peripheral nerve regeneration
Peripheral nerve injuries represent a major clinical challenge, if nerve ends retract, there is no spontaneous regeneration, and grafts are required...
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Platelet-rich plasma loaded nerve guidance conduit as implantable biocompatible materials for recurrent laryngeal nerve regeneration
Vocal cord paralysis caused by recurrent laryngeal nerve (RLN) injury during thyroidectomy results in hoarseness, aspiration, and dyspnea. We...
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Genetic Features of Young and Aged Animals After Peripheral Nerve Injury: Implications for Diminished Regeneration Capacity
The spontaneous regeneration capacity of peripheral nerves is fundamentally reduced with advancing age, leading to severe and long-term functional...
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M2 macrophage-derived cathepsin S promotes peripheral nerve regeneration via fibroblast–Schwann cell-signaling relay
BackgroundAlthough peripheral nerves have an intrinsic self-repair capacity following damage, functional recovery is limited in patients. It is a...
