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Differential behaviors of calcium-induced calcium release in one dimensional dendrite by Nernst–Planck equation, cable model and pure diffusion model
The source and dynamics of calcium is the key factor that regulates dendritic integration. Apart from the voltage-gated and ligand-gated calcium...
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An Algorithm Based on a Cable-Nernst Planck Model Predicting Synaptic Activity throughout the Dendritic Arbor with Micron Specificity
Recent technological advances have enabled the recording of neurons in intact circuits with a high spatial and temporal resolution, creating the...
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A Refined Thin-Film Model for Drug Dissolution Considering Radial Diffusion – Simulating Powder Dissolution
PurposeWe aim to present a refined thin-film model describing the drug particle dissolution considering radial diffusion in spherical boundary layer,...
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Ion-concentration gradients induced by synaptic input increase the voltage depolarization in dendritic spines
The vast majority of excitatory synaptic connections occur on dendritic spines. Due to their extremely small volume and spatial segregation from the...
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Modeling Drug Dissolution in 3-Dimensional Space
PurposeThe purpose of the study is to present a mathematical model capable of describing drug particle dissolution in 3-dimensional (3D) space, and...
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Neuronal Encoding Models
This review summarizes the basic information about neurons and their mechanisms and it presents a variety of the mathematical models applied in... -
Drug Release
Drug release from dosage forms (also termed drug liberation) is a prerequisite for absorption to occur: only free molecules in solution can cross... -
Controlling Cell Membrane Potential with Static Nonuniform Magnetic Fields
The coordinated activity of a myriad of ion channels in a cell is a spectacular biological and physical phenomenon. Understanding mechanisms... -
Basics Theory
Basic electrochemical principles essential for the understanding of electrophysiology shall be presented in this chapter. This topic includes... -
Measuring Reversal Potentials
The reversal potential refers to the membrane potential at which the current changes its flowing direction. For electrophysiological measurements,... -
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Electrical Theory
The basic flow of ions into or out of a cell has the potential to greatly impact the propagation of electrical signals. This chapter focuses on the... -
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Application of Liquisolid Pellets Technology for Improving Dissolution of Posaconazole: A DoE Based Process Optimization
PurposePosaconazole (PSZ) is BCS class-II drug that displays variable bioavailability upon oral administration due to extremely low and pH-dependent...