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N-Acetyl Serotonin Provides Neuroprotective Effects by Inhibiting Ferroptosis in the Neonatal Rat Hippocampus Following Hypoxic Brain Injury
Hypoxic-ischemic encephalopathy is the main cause of infant brain damage, perinatal death, and chronic neonatal disability worldwide. Ferroptosis is...
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Transient neonatal hyperglycemia induces metabolic shifts in the rat hippocampus: a 1H NMR-based metabolomics analysis
Diabetes has been reported to induce brain metabolic disturbance, but the effect of transient neonatal hyperglycemia (TNH) on brain metabolism...
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Differential Effects of Neonatal Ventral Hippocampus Lesion on Behavior and Corticolimbic Plasticity in Wistar–Kyoto and Spontaneously Hypertensive Rats
Dysfunction of the corticolimbic system, particularly at the dendritic spine level, is a recognized core mechanism in neurodevelopmental disorders...
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Neurogenesis in the neonatal rat hippocampus is regulated by sexually dimorphic epigenetic modifiers
BackgroundNeurogenesis in the hippocampus endures across the lifespan but is particularly prolific during the first postnatal week in the develo**...
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Interneuronal GluK1 kainate receptors control maturation of GABAergic transmission and network synchrony in the hippocampus
Kainate type glutamate receptors (KARs) are strongly expressed in GABAergic interneurons and have the capability of modulating their functions via...
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Neonatal Isoflurane Exposure in Rats Impairs Short-Term Memory, Cell Viability, and Glutamate Uptake in Slices of the Frontal Cerebral Cortex, But Not the Hippocampus, in Adulthood
Neonatal exposure to general anesthetics has been associated with neurotoxicity and morphologic changes in the develo** brain. Isoflurane is a...
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Neonatal IL-4 Over-Exposure is Accompanied by Macrophage Accumulation in Dura Mater After Instant Anti-inflammatory Cytokine Response in CSF
Multiple studies have shown that clinical events resulting into neonatal IL-4 over-exposure, such as asthma in early life and food allergy, were...
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Effect of Early Inhibition of Toll-Like Receptor 4 on Hippocampal Plasticity in a Neonatal Rat Model of Hypoxic-Ischemic Brain Damage
Hippocampal plasticity is closely related to physiological brain functions such as learning and memory. However, the effect of toll-like receptor 4...
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GSDMD gene knockout alleviates hyperoxia-induced hippocampal brain injury in neonatal mice
BackgroundNeonatal hyperoxia exposure is associated with brain injury and poor neurodevelopment outcomes in preterm infants. Our previous studies in...
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PHLDA1 contributes to hypoxic ischemic brain injury in neonatal rats via inhibiting FUNDC1-mediated mitophagy
Hypoxia-ischemia (HI) is one of the main causes of neonatal brain injury. Mitophagy has been implicated in the degradation of damaged mitochondria...
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Melatonin Modulates Cell Cycle Dynamics and Promotes Hippocampal Cell Proliferation After Ischemic Injury in Neonatal Rats
Promoting neural cell proliferation may represent an important strategy for enhancing brain repair after developmental brain injury. The present...
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MANF Alleviates Sevoflurane-Induced Cognitive Impairment in Neonatal Mice by Modulating Microglial Activation and Polarization
The precise mechanism underlying sevoflurane-induced neurotoxicity and cognitive impairment remains largely unknown. Mesencephalic astrocyte-derived...
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Blockade of the NLRP3/caspase-1 axis attenuates ketamine-induced hippocampus pyroptosis and cognitive impairment in neonatal rats
BackgroundMultiple studies have revealed that repeated or long-term exposure to ketamine causes neurodegeneration and cognitive dysfunction....
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Fetal inflammation induces acute immune tolerance in the neonatal rat hippocampus
BackgroundInfants born preterm due to chorioamnionitis are frequently affected by a fetal inflammatory response syndrome (FIRS) and then by...
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Neonatal inflammation increases hippocampal KCC2 expression through methylation-mediated TGF-β1 downregulation leading to impaired hippocampal cognitive function and synaptic plasticity in adult mice
The mechanisms by which neonatal inflammation leads to cognitive deficits in adulthood remain poorly understood. Inhibitory GABAergic synaptic...
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Early Sharp Wave Synchronization along the Septo-Temporal Axis of the Neonatal Rat Hippocampus
In the neonatal rat hippocampus, the first and predominant pattern of synchronized neuronal network activity is early sharp waves (eSPWs) occurring...
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Developmental Changes in Early Sharp Waves in the Hippocampus of Neonatal Rats
Synchronized activity the hallmark of neural networks. Early sharp waves (eSPW) form one type of synchronized activity – these are synchronized...
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PP2A-associated tau hyperphosphorylation was involved in sevoflurane induced neonatal neurotoxicity
BackgroundThe effects of sevoflurane anesthesia on childhood neurodevelopment and adult brain function have attracted increasing scientific...
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Neonatal phencyclidine as a model of sex-biased schizophrenia symptomatology in adolescent mice
Sex-biased differences in schizophrenia are evident in several features of the disease, including symptomatology and response to pharmacological...
