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Fetal Thymic Organ Culture and Negative Selection
Negative selection removes potentially harmful T cell precursors from the conventional T cell pool. This process can involve the induction of...
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I-Ag7 β56/57 polymorphisms regulate non-cognate negative selection to CD4+ T cell orchestrators of type 1 diabetes
Genetic susceptibility to type 1 diabetes is associated with homozygous expression of major histocompatibility complex class II alleles that carry...
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A double-negative thymocyte-specific enhancer augments Notch1 signaling to direct early T cell progenitor expansion, lineage restriction and β-selection
T cell differentiation requires Notch1 signaling. In the present study, we show that an enhancer upstream of Notch1 active in double-negative (DN)...
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The need for a clinical case definition in test-negative design studies estimating vaccine effectiveness
Test negative studies have been used extensively for the estimation of COVID-19 vaccine effectiveness (VE). Such studies are able to estimate VE...
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Unrealized targets in the discovery of antibiotics for Gram-negative bacterial infections
Advances in areas that include genomics, systems biology, protein structure determination and artificial intelligence provide new opportunities for...
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Semi-supervised bipartite graph construction with active EEG sample selection for emotion recognition
AbstractElectroencephalogram (EEG) signals are derived from the central nervous system and inherently difficult to camouflage, leading to the recent...
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Distinguishing Patients with MRI-Negative Temporal Lobe Epilepsy from Normal Controls Based on Individual Morphological Brain Network
Temporal Lobe Epilepsy (TLE) is the most common subtype of focal epilepsy and the most refractory to drug treatment. Roughly 30% of patients do not...
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A guide to thymic selection of T cells
The thymus is an evolutionarily conserved organ that supports the development of T cells. Not only does the thymic environment support the...
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Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors
In cancer, evolutionary forces select for clones that evade the immune system. Here we analyzed >10,000 primary tumors and 356...
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Development and optimization of expected cross value for mate selection problems
In this study, we address the mate selection problem in the hybridization stage of a breeding pipeline, which constitutes the multi-objective...
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Dose selection for aztreonam-avibactam, including adjustments for renal impairment, for Phase IIa and Phase III evaluation
PurposeA series of iterative population pharmacokinetic (PK) modeling and probability of target attainment (PTA) analyses based on emerging data...
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Identification of OSAHS patients based on ReliefF-mRMR feature selection
Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) is a serious chronic sleep disorder. Snoring is a common and easily observable symptom of OSAHS...
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Population improvement via recurrent selection drives genetic gain in upland rice breeding
One of the main challenges of breeding programs is to identify superior genotypes from a large number of candidates. By gradually increasing the...
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Targeted multi-epitope switching enables straightforward positive/negative selection of CAR T cells
Chimeric antigen receptor (CAR) T cell technology has enabled successfully novel concepts to treat cancer patients, with substantial remission rates...
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The plasma proteome differentiates the multisystem inflammatory syndrome in children (MIS-C) from children with SARS-CoV-2 negative sepsis
BackgroundThe Multi-System Inflammatory Syndrome in Children (MIS-C) can develop several weeks after SARS-CoV-2 infection and requires a distinct...
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Locus-level antagonistic selection shaped the polygenic architecture of human complex diseases
BackgroundWe aimed to evaluate the potential role of antagonistic selection in polygenic diseases: if one variant increases the risk of one disease...
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Transcriptomics of differences in thermal plasticity associated with selection for an exaggerated male sexual trait
The information about the magnitude of differences in thermal plasticity both between and within populations, as well as identification of the...
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A TAN-dopamine interaction mechanism based computational model of basal ganglia in action selection
The basal ganglia (BG) plays a key role in action selection. Physiological experiments have suggested that the reciprocal interaction between...
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Brain Response of Major Depressive Disorder Patients to Emotionally Positive and Negative Music
Depression is characterized by poor emotion regulation that makes it difficult to escape the effects of emotional pain, but the neuromodulation...
