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Inhibition of Neural Stem Cell Necroptosis Mediated by RIPK1/MLKL Promotes Functional Recovery After SCI
Endogenous neural stem cells (eNSCs) are a new therapeutic strategy for the noninvasive repair of spinal cord injury (SCI). Necroptosis is a...
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Targeting Necroptosis as Therapeutic Potential in Central Nervous System Diseases
Necroptosis is a regulated cell death (RCD) induced by receptor interacting protein kinase 3 (RIPK3) and mixed lineage kinase domain-like protein...
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GSDMD/Drp1 signaling pathway mediates hippocampal synaptic damage and neural oscillation abnormalities in a mouse model of sepsis-associated encephalopathy
BackgroundGasdermin D (GSDMD)-mediated pyroptotic cell death is implicated in the pathogenesis of cognitive deficits in sepsis-associated...
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Targeting PAX8 sensitizes ovarian cancer cells to ferroptosis by inhibiting glutathione synthesis
Ovarian cancer is a malignant tumor originating from the ovary, characterized by its high mortality rate and propensity for recurrence. In some...
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The regulation of necroptosis and perspectives for the development of new drugs preventing ischemic/reperfusion of cardiac injury
In the last 10 years, mortality from acute myocardial infarction (AMI) has not significantly decreased. This situation is associated with the absence...
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Acute exposure to polystyrene nanoparticles promotes liver injury by inducing mitochondrial ROS-dependent necroptosis and augmenting macrophage-hepatocyte crosstalk
BackgroundThe global use of plastic materials has undergone rapid expansion, resulting in the substantial generation of degraded and synthetic...
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Microglial and Neuronal Cell Pyroptosis Induced by Oxygen–Glucose Deprivation/Reoxygenation Aggravates Cell Injury via Activation of the Caspase-1/GSDMD Signaling Pathway
Pyroptosis is a new type of programmed cell death, which induces a strong pro-inflammatory reaction. However, the mechanism of pyroptosis after brain...
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Targeting Necroptosis as Therapeutic Potential in Central Nervous System Diseases
Necroptosis is a regulated cell death (RCD) induced by receptor interacting protein kinase 3 (RIPK3) and mixed lineage kinase domain-like protein...
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Approaches to Evaluating Necroptosis in Virus-Infected Cells
The immune system functions to protect the host from pathogens. To counter host defense mechanisms, pathogens have developed unique strategies to...
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CDK1 serves as a therapeutic target of adrenocortical carcinoma via regulating epithelial–mesenchymal transition, G2/M phase transition, and PANoptosis
BackgroundAdrenocortical carcinoma (ACC) is an extremely rare, aggressive tumor with few effective therapeutic options or drugs. Mitotane (Mtn),...
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Necroptosis inhibitors: mechanisms of action and therapeutic potential
Necroptosis is a type of programmed cell death that is morphologically similar to necrosis. This type of cell death is involved in various...
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Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis
Glioblastoma (GBM), a malignant brain tumor, is a world-wide health problem because of its poor prognosis and high rates of recurrence and mortality....
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NLRP1 inflammasome promotes senescence and senescence-associated secretory phenotype
BackgroundSenescence is a cellular aging-related process triggered by different stresses and characterized by the secretion of various inflammatory...
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Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets
Diseases associated with chronic inflammation constitute a major health burden across the world. As central instigators of the inflammatory response...
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Exogenous IGF-1 improves tau pathology and neuronal pyroptosis in high-fat diet mice with cognitive dysfunction
Insulin-like growth factor-1 (IGF-1) improves obesity-induced cognitive dysfunction, but its mechanism is not fully clarified. The aim of the study...
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Role of Necroptosis, a Regulated Cell Death, in Seizure and Epilepsy
Epilepsy is a chronic neurological disease that is characterized by spontaneous and recurrent seizures. Regulated cell death is a controlled process...
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Novel Mechanisms of Perioperative Neurocognitive Disorders: Ferroptosis and Pyroptosis
Perioperative neurocognitive disorders (PNDs) are some of the most common postoperative complications among the elderly and susceptible individuals,...
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Pyroptosis in bone loss
Pyroptosis could be responsible for the bone loss from bone metabolic diseases, leading to the negative impact on people's health and life. It has...
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SNORA56-mediated pseudouridylation of 28 S rRNA inhibits ferroptosis and promotes colorectal cancer proliferation by enhancing GCLC translation
BackgroundColorectal cancer (CRC) is one of the most common malignancies and is characterized by reprogrammed metabolism. Ferroptosis, a programmed...
