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A Hypermutable Region in the DISP2 Gene Links to Natural Selection and Late-Onset Neurocognitive Disorders in Humans
(CCG) short tandem repeats (STRs) are predominantly enriched in genic regions, mutation hotspots for C to T truncating substitutions, and involved in...
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Genetic diversity and natural selection of Plasmodium vivax reticulocyte invasion genes in Ecuador
BackgroundKnowledge of the diversity of invasion ligands in malaria parasites in endemic regions is essential to understand how natural selection...
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Pathogenic Interleukin-10 Receptor Alpha Variants in Humans — Balancing Natural Selection and Clinical Implications
Balancing natural selection is a process by which genetic variants arise in populations that are beneficial to heterozygous carriers, but pathogenic...
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Evidence of natural selection and dominance of SARS-CoV-2 variant Lambda (C.37) over variants of concern in Cusco, Peru
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineage C.37 (Lambda) has spread rapidly in Peru and other Latin American countries....
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Concepts of Natural Selection in Light of Phage Exposure
This chapter provides a transition from more specific aspects of natural selection—selection for phage resistance in bacteria along with secondary...
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Host adaptation of codon usage in SARS-CoV-2 from mammals indicates potential natural selection and viral fitness
SARS-CoV-2 infection, which is the cause of the COVID-19 pandemic, has expanded across various animal hosts, and the virus can be transmitted...
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Genomic stratification and differential natural selection signatures among human norovirus genogroup II isolates
Noroviruses (NoVs), which are members of the family Caliciviridae , are the most common cause of gastroenteritis in humans. Ten NoV genogroups have...
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Global Research on Natural Disasters and Human Health: a Map** Study Using Natural Language Processing Techniques
Purpose of ReviewThis review aimed to systematically synthesize the global evidence base for natural disasters and human health using natural...
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Selection on synonymous sites: the unwanted transcript hypothesis
Although translational selection to favour codons that match the most abundant tRNAs is not readily observed in humans, there is nonetheless...
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Genetic diversity and signatures of selection in four indigenous horse breeds of Iran
Indigenous Iranian horse breeds were evolutionarily affected by natural and artificial selection in distinct phylogeographic clades, which shaped...
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A guide to thymic selection of T cells
The thymus is an evolutionarily conserved organ that supports the development of T cells. Not only does the thymic environment support the...
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Locus-level antagonistic selection shaped the polygenic architecture of human complex diseases
BackgroundWe aimed to evaluate the potential role of antagonistic selection in polygenic diseases: if one variant increases the risk of one disease...
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Natural Biopolymers as Scaffold
Earlier, natural compounds and their structural analogs have significantly influenced pharmacology, particularly for the treatment of cancer and...
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Chemotherapy-induced PTEN-L secretion promotes the selection of PTEN-deficient tumor cells
BackgroundPTEN loss has been identified in various tumor types and is linked to unfavorable clinical outcomes. In addition to PTEN mutation, multiple...
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Discovery of novel natural products for mosquito control
Vector control plays a key role in reducing the public health burden of mosquito-borne diseases. Today’s vector control strategies largely rely on...
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A Genetic-Demographic Analysis of Natural Reproduction Parameters and Crow’s Indices for Ethnic Groups of Moscow and St. Petersburg (Based on the 2010 All-Russia’s Population Census)
Based on the analysis of the data of the 2010 All-Russia’s Population census and the demographic statistics of Rosstat Agency, the...
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Signals of Directed Selection in the Indigenous Populations of Siberia
AbstractThe indigenous populations of Siberia are of significant interest for population genomics because of the specificity of their gene pools,...
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Mathematical Modeling of Selection by Sex-Limited Trait: To the Question of Maintenance of Litter Size Polymorphism in Natural Populations of Arctic Foxes
AbstractThis paper proposes a model of selection by a sex-limited trait expressed in females. The model was modified to describe natural selection...
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A systematic safety pipeline for selection of T-cell receptors to enter clinical use
Cancer immunotherapy using T cell receptor-engineered T cells (TCR-Ts) represents a promising treatment option. However, technologies for...
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Sodium levels and grazing pressure shape natural communities of the intracellular pathogen Legionella
BackgroundLegionella are parasites of freshwater protozoa, responsible for Legionellosis. Legionella can be found in a variety of aquatic...
