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The nexus of natural killer cells and melanoma tumor microenvironment: crosstalk, chemotherapeutic potential, and innovative NK cell-based therapeutic strategies
The metastasis of melanoma cells to regional lymph nodes and distant sites is an important contributor to cancer-related morbidity and mortality...
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Ex vivo expanded allogeneic natural killer cells have potent cytolytic activity against cancer cells through different receptor-ligand interactions
BackgroundRecently, allogeneic natural killer (NK) cells have gained considerable attention as promising immunotherapeutic tools due to their unique...
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Death receptors 4/5 mediate tumour sensitivity to natural killer cell-mediated cytotoxicity in mismatch repair deficient colorectal cancer
BackgroundIdentifying the target of natural killer (NK) cells in colorectal cancer (CRC) is critical for optimising the clinical use of NK...
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Natural killer cell-related gene signature predicts malignancy of glioma and the survival of patients
BackgroundNatural killer (NK) cells-based therapies are one of the most promising strategies against cancer. The aim of this study is to investigate...
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Roles of natural killer cells in immunity to cancer, and applications to immunotherapy
Great strides have been made in recent years towards understanding the roles of natural killer (NK) cells in immunity to tumours and viruses. NK...
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Distinct developmental pathways generate functionally distinct populations of natural killer cells
Natural killer (NK) cells function by eliminating virus-infected or tumor cells. Here we identified an NK-lineage-biased progenitor population,...
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The TNFα/TNFR2 axis mediates natural killer cell proliferation by promoting aerobic glycolysis
Natural killer (NK) cells are predominant innate lymphocytes that initiate the early immune response during infection. NK cells undergo a metabolic...
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CIS deletion by CRISPR/Cas9 enhances human primary natural killer cell functions against allogeneic glioblastoma
BackgroundGlioblastoma (GBM) is the most common malignant brain tumor and has “immunologically cold” features. Changing GBM to an “immunologically...
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Identification, sorting and profiling of functional killer cells via the capture of fluorescent target-cell lysate
Assays for assessing cell-mediated cytotoxicity are largely target-cell-centric and cannot identify and isolate subpopulations of cytotoxic effector...
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Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver
Obesity is a major risk factor for cancers including hepatocellular carcinoma (HCC) that develops from a background of non-alcoholic fatty liver...
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Directly reprogrammed natural killer cells for cancer immunotherapy
Efficacious and accessible sources of natural killer (NK) cells would widen their use as immunotherapeutics, particularly for solid cancers. Here, we...
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Diversity of group 1 innate lymphoid cells in human tissues
Group 1 innate lymphoid cells (ILC1s) are cytotoxic and interferon gamma-producing lymphocytes lacking antigen-specific receptors, which include...
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Multifaceted characterization of the biological and transcriptomic signatures of natural killer cells derived from cord blood and placental blood
BackgroundPerinatal blood including umbilical cord blood and placental blood are splendid sources for allogeneic NK cell generation with high...
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CXCR4 and anti-BCMA CAR co-modified natural killer cells suppress multiple myeloma progression in a xenograft mouse model
The highly restricted expression of B-cell maturation antigen (BCMA) on plasma cells makes it an ideal target for chimeric antigen receptor (CAR)...
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The cancer–natural killer cell immunity cycle
Immunotherapy with checkpoint blockade induces rapid and durable immune control of cancer in some patients and has driven a monumental shift in...
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Natural killer group 2D receptor and its ligands in cancer immune escape
The immune system plays important roles in tumor development. According to the immune-editing theory, immune escape is the key to tumor survival, and...
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Group XIV C-type lectins: emerging targets in tumor angiogenesis
C-type lectins, distinguished by a C-type lectin binding domain (CTLD), are an evolutionarily conserved superfamily of glycoproteins that are...
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Neuroblast senescence in the aged brain augments natural killer cell cytotoxicity leading to impaired neurogenesis and cognition
Normal aging is accompanied by escalating systemic inflammation. Yet the potential impact of immune homeostasis on neurogenesis and cognitive decline...
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Co-expression of IL-21-Enhanced NKG2D CAR-NK cell therapy for lung cancer
BackgroundAdoptive cell therapy has achieved great success in treating hematological malignancies. However, the production of chimeric antigen...
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Blood CD3-(CD56 or 16)+ natural killer cell distributions are heterogeneous in healthy adults and suppressed by azathioprine in patients with ANCA-associated vasculitides
BackgroundCytotoxic Natural Killer (NK) cells are increasingly recognized as a powerful tool to induce targeted cell death in cancer and autoimmune...
