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1. Natural Killer (NK) Cells Methods and Protocols

   This detailed book provides a broad collection of methodologies for natural killer (NK) cell research. Beginning with an assortment of methods for...

   Noriko Shimasaki in Methods in Molecular Biology

   Book 2022
   

2. Invariant natural killer T cells in lung diseases

   Invariant natural killer T ( i NKT) cells are a subset of T cells that are characterized by a restricted T-cell receptor (TCR) repertoire and a unique...

   Dong** Jeong, Yeon Duk Woo, Doo Hyun Chung in Experimental & Molecular Medicine

   Article Open access 11 September 2023
   

3. Multimeric immunotherapeutic complexes activating natural killer cells towards HIV-1 cure

   Background

   Combination antiretroviral therapy (cART) has dramatically extended the life expectancy of people living with HIV-1 and improved their...

   Rafaëla Schober, Bianca Brandus, ... Carole Seguin-Devaux in Journal of Translational Medicine

   Article Open access 07 November 2023
   

4. Unraveling the dynamic mechanisms of natural killer cells in viral infections: insights and implications

   Viruses pose a constant threat to human well-being, necessitating the immune system to develop robust defenses. Natural killer (NK) cells, which play...

   Arash Letafati, Omid Salahi Ardekani, ... Sayed-Hamidreza Mozhgani in Virology Journal

   Article Open access 12 January 2024
   

5. DNA demethylase Tet2 promotes the terminal maturation of natural killer cells

   The cytotoxicity feature to eliminate malignant cells makes natural killer (NK) cells a candidate for tumor immunotherapy. However, this scenario is...

   Yuqing Lin, Biyun Yang, ... Yonghui Lu in Immunologic Research

   Article 13 June 2024
   

6. Natural killer cell-derived exosome-based cancer therapy: from biological roles to clinical significance and implications

   Natural killer (NK) cells are important immune cells in the organism and are the third major type of lymphocytes besides T cells and B cells, which...

   Chaohua Si, Jianen Gao, Xu Ma in Molecular Cancer

   Article Open access 29 June 2024
   

7. High and selective cytotoxicity of ex vivo expanded allogeneic human natural killer cells from peripheral blood against bladder cancer: implications for natural killer cell instillation after transurethral resection of bladder tumor

   Background

   Non-muscle-invasive bladder cancer (NMIBC) is treated with transurethral resection of bladder tumor (TURBT) followed by intravesical...

   Fangming Wang, Gang Zhang, ... Nianzeng **ng in Journal of Experimental & Clinical Cancer Research

   Article Open access 20 January 2024
   

8. An Imaging Flow Cytometry Method for Assessment of Human Natural Killer Cells

   Use of laser imaging flow cytometry for assessment of surface markers of human natural killer cells is considered. Cells were extracted from healthy...

   L. I. Popova, V. A. Rybachuk, ... E. V. Abakushina in Biomedical Engineering

   Article 14 July 2022

9. Upregulated complement receptors correlate with Fc gamma receptor 3A-positive natural killer and natural killer-T cells in neuromyelitis optica spectrum disorder

   Background and objectives

   Inhibition of terminal complement in neuromyelitis optica spectrum disorder (NMOSD) using eculizumab helps prevent relapses,...

   Shuhei Nishiyama, Amy E. Wright, ... Michael Levy in Journal of Neuroinflammation

   Article Open access 12 December 2022
   

10. Defining the role of natural killer cells in COVID-19

    Natural killer (NK) cells are critical effectors of antiviral immunity. Researchers have therefore sought to characterize the NK cell response to...

    Madeline J. Lee, Catherine A. Blish in Nature Immunology

    Article 17 July 2023
    

11. Natural killer cells in antitumour adoptive cell immunotherapy

    Natural killer (NK) cells comprise a unique population of innate lymphoid cells endowed with intrinsic abilities to identify and eliminate virally...

    Tamara J. Laskowski, Alexander Biederstädt, Katayoun Rezvani in Nature Reviews Cancer

    Article 25 July 2022
    

12. The nexus of natural killer cells and melanoma tumor microenvironment: crosstalk, chemotherapeutic potential, and innovative NK cell-based therapeutic strategies

    The metastasis of melanoma cells to regional lymph nodes and distant sites is an important contributor to cancer-related morbidity and mortality...

    Azadeh Rahimi, Zahra Malakoutikhah, ... Shaghayegh Haghjooy Javanmard in Cancer Cell International

    Article Open access 06 December 2023
    

13. Distinct developmental pathways generate functionally distinct populations of natural killer cells

    Natural killer (NK) cells function by eliminating virus-infected or tumor cells. Here we identified an NK-lineage-biased progenitor population,...

    Yi Ding, Marieke Lavaert, ... Avinash Bhandoola in Nature Immunology

    Article 13 June 2024
    

14. Natural killer cells drive 4-1BBL positive uveal melanoma towards EMT and metastatic disease

    Background

    Inflammation in the eye is often associated with aggravated ocular diseases such as uveal melanoma (UM). Poor prognosis of UM is generally...

    Shi Yong Neo, Mariana M. S. Oliveira, ... Andreas Lundqvist in Journal of Experimental & Clinical Cancer Research

    Article Open access 09 January 2024
    

15. Current Developments in the Preclinical and Clinical use of Natural Killer T cells

    Natural killer T (NKT) cells play a pivotal role as a bridge between the innate and the adaptive immune response and are instrumental in the...

    Christina Kratzmeier, Sasha Singh, ... Tonya J. Webb in BioDrugs

    Article 16 December 2022
    

16. Accelerated epigenetic aging and decreased natural killer cells based on DNA methylation in patients with untreated major depressive disorder

    Major depressive disorder (MDD) is known to cause significant disability. Genome-wide DNA methylation (DNAm) profiles can be used to estimate...

    Ryota Shindo, Takaki Tanifuji, ... Akitoyo Hishimoto in npj Aging

    Article Open access 06 September 2023
    

17. Anti-TIM3 chimeric antigen receptor-natural killer cells from engineered induced pluripotent stem cells effectively target acute myeloid leukemia cells

    Background

    Acute myeloid leukemia (AML) is a clonal malignant disorder which originates from a small number of leukemia-initiating cells or leukemic...

    Phatchanat Klaihmon, Sudjit Luanpitpong, ... Surapol Issaragrisil in Cancer Cell International

    Article Open access 27 November 2023
    

18. Functional integration of natural killer cells in a microfluidically perfused liver on-a-chip model

    Objective

    The liver acts as an innate immunity-dominant organ and natural killer (NK) cells, are the main lymphocyte population in the human liver. NK...

    René Fahrner, Marko Gröger, ... Alexander S. Mosig in BMC Research Notes

    Article Open access 21 October 2023
    

19. Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells

    The persistence of CD4 ⁺ T cells carrying latent human immunodeficiency virus-1 (HIV-1) proviruses is the main barrier to a cure. New therapeutics to...

    Nathan L. Board, Zhe Yuan, ... Robert F. Siliciano in Nature Immunology

    Article Open access 26 January 2024
    

20. Natural killer cell-derived exosomes for cancer immunotherapy: innovative therapeutics art

    Chimeric antigen receptor natural killer cells (CAR-NK) promote off-the-shelf cellular therapy for solid tumors and malignancy.However,, the...

    Zahra Hatami, Zahra Sadat Hashemi, ... Reza Jafari in Cancer Cell International

    Article Open access 05 August 2023