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Natural killer cell-derived exosome-based cancer therapy: from biological roles to clinical significance and implications
Natural killer (NK) cells are important immune cells in the organism and are the third major type of lymphocytes besides T cells and B cells, which...
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Natural killer cell-derived exosomes for cancer immunotherapy: innovative therapeutics art
Chimeric antigen receptor natural killer cells (CAR-NK) promote off-the-shelf cellular therapy for solid tumors and malignancy.However,, the...
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High-dimensional single-cell analysis of human natural killer cell heterogeneity
Natural killer (NK) cells are innate lymphoid cells (ILCs) contributing to immune responses to microbes and tumors. Historically, their...
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Upregulated complement receptors correlate with Fc gamma receptor 3A-positive natural killer and natural killer-T cells in neuromyelitis optica spectrum disorder
Background and objectivesInhibition of terminal complement in neuromyelitis optica spectrum disorder (NMOSD) using eculizumab helps prevent relapses,...
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Natural Killer Cell Infiltration in Prostate Cancers Predict Improved Patient Outcomes
BackgroundNatural killer (NK) cells are non-antigen specific innate immune cells that can be redirected to targets of interest using multiple...
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Natural killer cells in antitumour adoptive cell immunotherapy
Natural killer (NK) cells comprise a unique population of innate lymphoid cells endowed with intrinsic abilities to identify and eliminate virally...
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High and selective cytotoxicity of ex vivo expanded allogeneic human natural killer cells from peripheral blood against bladder cancer: implications for natural killer cell instillation after transurethral resection of bladder tumor
BackgroundNon-muscle-invasive bladder cancer (NMIBC) is treated with transurethral resection of bladder tumor (TURBT) followed by intravesical...
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The TNFα/TNFR2 axis mediates natural killer cell proliferation by promoting aerobic glycolysis
Natural killer (NK) cells are predominant innate lymphocytes that initiate the early immune response during infection. NK cells undergo a metabolic...
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Death receptors 4/5 mediate tumour sensitivity to natural killer cell-mediated cytotoxicity in mismatch repair deficient colorectal cancer
BackgroundIdentifying the target of natural killer (NK) cells in colorectal cancer (CRC) is critical for optimising the clinical use of NK...
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Chimeric antigen receptor- and natural killer cell receptor-engineered innate killer cells in cancer immunotherapy
Chimeric antigen receptor (CAR)-engineered T-cell (CAR-T) therapy has demonstrated impressive therapeutic efficacy against hematological...
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Mediastinal lymph node removal modulates natural killer cell exhaustion in patients with non-small cell lung cancer
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death globally. In this study, the effect of complete removal of...
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CD19/CD20 dual-targeted chimeric antigen receptor-engineered natural killer cells exhibit improved cytotoxicity against acute lymphoblastic leukemia
BackgroundChimeric antigen receptor natural killer (CAR-NK) cells represent a promising advancement in CAR cell therapy, addressing limitations...
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The effects of killer cell immunoglobulin-like receptor (KIR) genes on susceptibility to severe COVID-19 in the Iranian population
BackgroundVariations in the innate and adaptive immune response systems are linked to variations in the severity of COVID-19. Natural killer cell...
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Autologous dendritic cell vaccination against HIV-1 induces changes in natural killer cell phenotype and functionality
Although natural killer (NK) cells have been studied in connection with dendritic cell (DC)-based vaccination in the field of cancer immunology,...
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The nexus of natural killer cells and melanoma tumor microenvironment: crosstalk, chemotherapeutic potential, and innovative NK cell-based therapeutic strategies
The metastasis of melanoma cells to regional lymph nodes and distant sites is an important contributor to cancer-related morbidity and mortality...
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Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells
The persistence of CD4 + T cells carrying latent human immunodeficiency virus-1 (HIV-1) proviruses is the main barrier to a cure. New therapeutics to...
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Invariant natural killer T cells in lung diseases
Invariant natural killer T ( i NKT) cells are a subset of T cells that are characterized by a restricted T-cell receptor (TCR) repertoire and a unique...
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CCR2+TREM-1+ monocytes promote natural killer T cell dysfunction contributing towards HBV disease progression
Natural killer T (NKT) cells are amongst the most important innate immune cells against hepatitis B virus (HBV) infection. Moreover, previous studies...
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Anti-TIM3 chimeric antigen receptor-natural killer cells from engineered induced pluripotent stem cells effectively target acute myeloid leukemia cells
BackgroundAcute myeloid leukemia (AML) is a clonal malignant disorder which originates from a small number of leukemia-initiating cells or leukemic...
