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Natural killer cell-derived exosomes for cancer immunotherapy: innovative therapeutics art
Chimeric antigen receptor natural killer cells (CAR-NK) promote off-the-shelf cellular therapy for solid tumors and malignancy.However,, the...
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Natural Killer Cell Infiltration in Prostate Cancers Predict Improved Patient Outcomes
BackgroundNatural killer (NK) cells are non-antigen specific innate immune cells that can be redirected to targets of interest using multiple...
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High and selective cytotoxicity of ex vivo expanded allogeneic human natural killer cells from peripheral blood against bladder cancer: implications for natural killer cell instillation after transurethral resection of bladder tumor
BackgroundNon-muscle-invasive bladder cancer (NMIBC) is treated with transurethral resection of bladder tumor (TURBT) followed by intravesical...
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Natural killer cells in antitumour adoptive cell immunotherapy
Natural killer (NK) cells comprise a unique population of innate lymphoid cells endowed with intrinsic abilities to identify and eliminate virally...
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EZH2 K63-polyubiquitination affecting migration in extranodal natural killer/T-cell lymphoma
BackgroundOverexpressed EZH2 is oncogenically involved in the pathogenesis of different cancerous contexts including extranodal natural killer/T cell...
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Natural Killer (NK) Cells Methods and Protocols
This detailed book provides a broad collection of methodologies for natural killer (NK) cell research. Beginning with an assortment of methods for...
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Mediastinal lymph node removal modulates natural killer cell exhaustion in patients with non-small cell lung cancer
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death globally. In this study, the effect of complete removal of...
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CCR2+TREM-1+ monocytes promote natural killer T cell dysfunction contributing towards HBV disease progression
Natural killer T (NKT) cells are amongst the most important innate immune cells against hepatitis B virus (HBV) infection. Moreover, previous studies...
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Autologous dendritic cell vaccination against HIV-1 induces changes in natural killer cell phenotype and functionality
Although natural killer (NK) cells have been studied in connection with dendritic cell (DC)-based vaccination in the field of cancer immunology,...
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The nexus of natural killer cells and melanoma tumor microenvironment: crosstalk, chemotherapeutic potential, and innovative NK cell-based therapeutic strategies
The metastasis of melanoma cells to regional lymph nodes and distant sites is an important contributor to cancer-related morbidity and mortality...
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The TNFα/TNFR2 axis mediates natural killer cell proliferation by promoting aerobic glycolysis
Natural killer (NK) cells are predominant innate lymphocytes that initiate the early immune response during infection. NK cells undergo a metabolic...
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Organoid Co-culture Methods to Capture Cancer Cell–Natural Killer Cell Interactions
Metastasis is a complex process that has been historically difficult to model in culture. Host immune responses play critical roles in restraining...
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Death receptors 4/5 mediate tumour sensitivitNot applicably to natural killer cell-mediated cytotoxicity in mismatch repair deficient colorectal cancer
BackgroundIdentifying the target of natural killer (NK) cells in colorectal cancer (CRC) is critical for optimising the clinical use of NK...
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Natural killer cell-related gene signature predicts malignancy of glioma and the survival of patients
BackgroundNatural killer (NK) cells-based therapies are one of the most promising strategies against cancer. The aim of this study is to investigate...
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Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells
The persistence of CD4 + T cells carrying latent human immunodeficiency virus-1 (HIV-1) proviruses is the main barrier to a cure. New therapeutics to...
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Fusogenic vesicular stomatitis virus combined with natural killer T cell immunotherapy controls metastatic breast cancer
BackgroundMetastatic breast cancer is a leading cause of cancer death in woman. Current treatment options are often associated with adverse side...
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Invariant natural killer T cells in lung diseases
Invariant natural killer T ( i NKT) cells are a subset of T cells that are characterized by a restricted T-cell receptor (TCR) repertoire and a unique...
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Cross-Talk between Mucosal-Associated Invariant T, Natural Killer, and Natural Killer T Cell Populations is Implicated in the Pathogenesis of Placenta Accreta Spectrum
The study included 32 women with PAS and 20 with normally implanted placenta as a control group. Vascular endothelial cell growth factor (VEGF),...
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Natural Killer Cell Defects
Natural killer (NK) cells are innate lymphocytes that play an essential role in immune defense against viral infections and in tumor surveillance....