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Species of Arnebia Genus Found in the Western Himalayas: Arnebia euchroma (Royle ex Benth.), Arnebia benthamii (Wall. Ex G Don) Johnston, Arnebia guttata Bunge
Plants are a valuable treasurer of nature and have abundant bioactive constituents with immunomodulatory properties. Arnebia is a critically...
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Targeting NQO1/GPX4-mediated ferroptosis by plumbagin suppresses in vitro and in vivo glioma growth
BackgroundFerroptosis has attracted increasing interest in cancer therapy. Emerging evidences suggest that naturally occurring naphthoquinones...
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Shikonin
Shikonin is a naphthoquinone isolated from Arnebia species such as Arnebia euchroma. The dried root of A.euchroma is a traditional Chinese medicine...
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Signalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancer
Epigenetic silencing of tumor suppressor genes (TSGs) through DNA methylation and histone changes is a main hallmark of cancer. U biquitin-like with P H ...
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Synthesis, antibacterial and antifungal activities of naphthoquinone derivatives: a structure–activity relationship study
The synthesis of 1,4-naphthoquinone derivatives is of great interest since these compounds exhibit strong activity as antimalarial, antibacterial,...
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Acute and 28-Day Subacute Toxicity Studies of Hexane Extracts of the Roots of Lithospermum erythrorhizon in Sprague-Dawley Rats
Lithospermum erythrorhizon has long been used as a traditional oriental medicine. In this study, the acute and 28-day subacute oral dose toxicity...
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Antitumor Activity of DMAKO-05, a Novel Shikonin Derivative, and Its Metabolism in Rat Liver Microsome
The antitumor activity of shikonin derivatives is largely dependent on the generation of superoxide radicals and the alkylation activity of their...
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Evidence for Synergism Between Cell Death Mechanisms in a Cellular Model of Neurodegeneration in Parkinson’s Disease
Delineation of how cell death mechanisms associated with Parkinson’s disease (PD) interact and whether they converge would help identify targets for...
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The microtubule depolymerizing agent naphthazarin induces both apoptosis and autophagy in A549 lung cancer cells
Naphthazarin (DHNQ, 5,8-dihydroxy-l,4-naphthoquinone) is a naturally available 1,4-naphthoquinone derivatives. In this study, we focused on...
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Pharmacological Potential of Natural Compounds in the Control of Selected Protozoan Diseases
Malaria, trypanosomiasis, and leishmaniasis (neglected tropical diseases), belong to the most devastating diseases affecting humans and animals in...
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Mitochondrial Dysfunction Precedes Other Sub-Cellular Abnormalities in an In Vitro Model Linked with Cell Death in Parkinson’s Disease
Dysfunction of mitochondria, the ubiquitin proteasome system (UPS), and lysosomes are believed to contribute to the pathogenesis of Parkinson’s...
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Anti-inflammatory and anti-nociceptive effects of the ethanolic extracts of Alkanna frigida and Alkanna orientalis
Alkanna species are used in Iranian traditional medicine for treatment of rheumatoid arthritis and other inflammatory diseases. This study was...
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Evidence-based Anticancer Materia Medica for Cervical Cancer
Carcinoma of the cervix is the second most common malignant neoplasia among women, following breast cancer. Approximately 500,000 new cases of cervix...
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Development and Validation of a Screening Assay for the Evaluation of Putative Neuroprotective Agents in the Treatment of Parkinson’s Disease
Following initial diagnosis of Parkinson’s disease, if it were possible to prescribe a treatment that could halt or prevent further...
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Regulation of apoptosis-associated lysosomal membrane permeabilization
Lysosomal membrane permeabilization (LMP) occurs in response to a large variety of cell death stimuli causing release of cathepsins from the...
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Preparation of gallic acid-chitosan complex (eco-brown) and its application for adsorption of mutagens and carcinogens
Gallic acid was reported to suppress the mutagenicity and to inhibit the metabolic activation. Chitosan is a unique polysaccharide derived from...
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Quantitative determination of acetylshikonin in macaque monkey blood by LC-ESI-MS/MS after precolumn derivatization with 2-mercaptoethanol and its application in pharmacokinetic study
Aim:To develop and validate a novel precolumn derivatization method for the quantitative determination and pharmacokinetic application of...
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Proteolytic Mechanisms of Cell Death in the Central Nervous System
The proteases implicated in programmed cell death herein discussed are involved in many normal and critical physiological functions within the...
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Volume 6 Indexes
This index lists all 3367 normalized pharmacological activity terms appeared in the encyclopedia in alphabetical order and a number code sequence of...