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A century of exercise physiology: effects of muscle contraction and exercise on skeletal muscle Na+,K+-ATPase, Na+ and K+ ions, and on plasma K+ concentration—historical developments
This historical review traces key discoveries regarding K + and Na + ions in skeletal muscle at rest and with exercise, including contents and...
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Disrupting Na+ ion homeostasis and Na+/K+ ATPase activity in breast cancer cells directly modulates glycolysis in vitro and in vivo
BackgroundGlycolytic flux is regulated by the energy demands of the cell. Upregulated glycolysis in cancer cells may therefore result from increased...
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Nonthyroidal illness syndrome (NTIS) in severe COVID-19 patients: role of T3 on the Na/K pump gene expression and on hydroelectrolytic equilibrium
BackgroundNonthyroidal Illness Syndrome (NTIS) can be detected in many critical illnesses. Recently, we demonstrated that this condition is...
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Ecstasy metabolites and monoamine neurotransmitters upshift the Na+/K+ ATPase activity in mouse brain synaptosomes
3,4-Methylenedioximethamphetamine (MDMA; “ecstasy”) is a psychotropic drug with well-known neurotoxic effects mediated by hitherto not fully...
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Screening of Peptides that Specifically Binds to M3-M4 Extracellular Domain of Sodium Pump α1 Subunit and Analysis of Their Bioactivity In Vitro and In Vivo
Interaction between ouabain (OUA) and Na + /K + -pump remains in the current focus of hypertension research. This study aimed to find an oligopeptide...
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Role of Na+,K+-ATPase in Bone Remodeling
The effects of cardiotonic steroids (ouabain and digoxin) on the bone formation were studied using the organotypic tissue culture in combination with...
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LPS-induced impairment of Na+/K+-ATPase activity: ameliorative effect of tannic acid in mice
Acetylcholine is an excitatory neurotransmitter that modulates synaptic plasticity and communication, and it is essential for learning and memory...
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Exercise and fatigue: integrating the role of K+, Na+ and Cl− in the regulation of sarcolemmal excitability of skeletal muscle
Perturbations in K + have long been considered a key factor in skeletal muscle fatigue. However, the exercise-induced changes in K + ...
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Role of Na+/K+-ATPase in ischemic stroke: in-depth perspectives from physiology to pharmacology
Na + /K + -ATPase (NKA) is a large transmembrane protein expressed in all cells. It is well studied for its ion exchanging function, which is...
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Parameters of Ionic and Acid-Base Balance during Assist Circulation with a LVAD Disc Pump
In chronic experiments on calves, the effect of the left-ventricular assist device (LVAD) technique by using a disc pump on the indicators of ionic...
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Ontogenetical development of branchial chambers of Litopenaeus vannamei (Boone, 1931) and their involvement in osmoregulation: ionocytes and Na+/K+-ATPase
Branchial chambers constitute the main osmoregulatory site in almost all decapod crustaceans. However, few studies have been devoted to elucidate the...
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Light-Driven Sodium Pump as a Potential Tool for the Control of Seizures in Epilepsy
The marine flavobacterium Krokinobactereikastus light-driven sodium pump (KR2) generates an outward sodium ion current under 530 nm light...
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Na+-K+-2Cl− Cotransporter
The conceptual breakthrough that the energy of the Na+ gradient generated by the Na+/K+ ATPase (pump) could be used as the driving force for another...
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Proton pump inhibitors associated with an increased risk of mortality in elderly: a systematic review and meta-analysis
PurposeThe increased use of proton pump inhibitors (PPIs) in the elderly has raised concerns about potential severe adverse effects. Our systematic...
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The Role of Na+/K+-ATPase in the Development of Hyponatrenemia under Conditions of Hypoxic Stress in Patients with SARS-CoV-2 Infection
We studied laboratory parameters of patients with COVID-19 against the background of chronic pathologies (cardiovascular pathologies, obesity, type 2...
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Bacterial Drug Efflux Pump Inhibitors from Plants
The current global antimicrobial resistance (AMR) crisis is a serious hazard to public health, food security, and development. Drug-resistant...
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Effects of Long-Acting Testosterone Undecanoate on Behavioral Parameters and Na + , K+-ATPase mRNA Expression in Mice with Alzheimer`s Disease
Previous studies have shown that testosterone attenuates stress-induced mood dysfunction and memory deterioration. However, the exact mechanism is...
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Protective Effects of Inosine on Memory Consolidation in a Rat Model of Scopolamine-Induced Cognitive Impairment: Involvement of Cholinergic Signaling, Redox Status, and Ion Pump Activities
AbstractThis study investigated the effects of inosine on memory acquisition and consolidation, cholinesterases activities, redox status and Na + , K + -...
