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Lactobacillus-derived extracellular vesicles counteract Aβ42-induced abnormal transcriptional changes through the upregulation of MeCP2 and Sirt1 and improve Aβ pathology in Tg-APP/PS1 mice
Mounting evidence suggests that probiotics are beneficial for treating Alzheimer’s disease (AD). However, the mechanisms by which specific probiotics...
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Exploring gene network and protein interaction analysis of neurotrophin signaling pathway in ameloblastoma
Ameloblastoma is a non-cancerous but aggressive oral tumor emerging from odontogenic epithelial tissue involved during odontogenesis. Since there is...
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Molecular and neural roles of sodium-glucose cotransporter 2 inhibitors in alleviating neurocognitive impairment in diabetic mice
Diabetes causes a variety of molecular changes in the brain, making it a real risk factor for the development of cognitive dysfunction. Complex...
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Unraveling psilocybin’s therapeutic potential: behavioral and neuroplasticity insights in Wistar-Kyoto and Wistar male rat models of treatment-resistant depression
RationaleOur study aimed to unravel the unknown mechanisms behind the exceptional efficacy of Psilocybin (PSI) in treating treatment-resistant...
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The Molecular Pathway of p75 Neurotrophin Receptor (p75NTR) in Parkinson’s Disease: The Way of New Inroads
Parkinson’s disease (PD) is a chronic and progressive neurodegenerative disease of the brain. PD is characterized by motor and non-motor symptoms....
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Extracellular Vesicles from Gram-positive and Gram-negative Probiotics Remediate Stress-Induced Depressive Behavior in Mice
Chronic stress causes maladaptive changes in the brain that lead to depressive behavior. In the present study, we investigate whether chronic stress...
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Role of Neurotrophins in Brain Tumor Development
Neurotrophins are the family of proteins responsible for many functions of neurons and their supporting cells in development, survival, and...
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Developmental Disorders of the Cerebellum and Neurotrophic Factors
The cerebellum plays a central role in motor control and cognition features such as attention. Thus, a disturbance in cerebellar development results...
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Priming and Combined Strategies for the Application of Mesenchymal Stem Cells in Ischemic Stroke: A Promising Approach
Ischemic stroke (IS) is a leading cause of death and disability worldwide. Tissue plasminogen activator (tPA) administration and mechanical...
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Neurotrophic Factors in Cerebellar Development and Function
Neurotrophic factors regulate numerous aspects of brain development, including the proliferation of neuronal precursors, neuronal migration,...
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Strategies to Upgrade the Stem Cell Application for Brain Transplantation
Introduction: Cerebral stem cellStem cell transplantation has the potential to replace dead cells and restore lost brain functions in...
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Quantum Dots: Functionalization and Theranostic Applications
In the last decade, nanotechnology has shown incredible growth and established itself as valuable technology to prepare highly specific biomedical...
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A Perspective on the Characterization of Early Neural Progenitor Cell-Derived Extracellular Vesicles for Targeted Delivery to Neuroblastoma Cells
As an element of the cellular signaling systems, extracellular vesicles (EVs) exhibit many desirable traits for usage as targeted delivery vehicles....
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A Review of Molecular Interplay between Neurotrophins and miRNAs in Neuropsychological Disorders
Various neurotrophins (NTs), including nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4, promote cellular...
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Preventive Effect of Two New Neurotensin Analogues on Parkinson’s Disease Rat Model
Close functional and anatomical interactions between the neurotensin (NT) and dopamine (DA) systems suggest that NT could be associated with...
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Comparative proteomics of oral squamous cell carcinoma tissue in consumers and non-consumers of tobacco
BackgroundTobacco is a risk factor for oral squamous cell carcinoma (OSCC). Some cases of OSCC occur without any known cause and is called idiopathic...
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Features of Remyelination after Transplantation of Olfactory Ensheathing Cells with Neurotrophic Factors into Spinal Cord Cysts
This paper shows for the first time that co-transplantation of human olfactory ensheathing cells with neurotrophin-3 into spinal cord cysts is more...
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Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis
BackgroundPersistent inflammatory response in the brain can lead to tissue damage and neurodegeneration. In Alzheimer's disease (AD), there is an...
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In Silico Analysis to Link Insulin Resistance, Obesity and Ageing with Alzheimer’s Disease
The process of ageing accompanies several metabolic diseases. With ageing, fats accumulate to increase the visceral and abdominal adiposity leading...
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Nasal delivery of a CRMP2-derived CBD3 adenovirus improves cognitive function and pathology in APP/PS1 transgenic mice
Calcium dysregulation is a key pathological event in Alzheimer’s disease (AD). In studying approaches to mitigate this calcium overload, we...
