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Histone methyltransferase Nsd2 ensures maternal–fetal immune tolerance by promoting regulatory T-cell recruitment
Regulatory T cells (Tregs) are fundamentally important for maintaining systemic immune homeostasis and are also required for immune tolerance at the...
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Loss-of-function and missense variants in NSD2 cause decreased methylation activity and are associated with a distinct developmental phenotype
PurposeDespite a few recent reports of patients harboring truncating variants in NSD2 , a gene considered critical for the Wolf–Hirschhorn syndrome...
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Low expression of NSD1, NSD2, and NSD3 define a subset of human papillomavirus-positive oral squamous carcinomas with unfavorable prognosis
BackgroundFrequent mutations in the nuclear receptor binding SET domain protein 1 ( NSD1 ) gene have been observed in head and neck squamous cell...
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The first familial NSD2 cases with a novel variant in a Chinese father and daughter with atypical WHS facial features and a 7.5-year follow-up of growth hormone therapy
BackgroundWolf-Hirschhorn syndrome is a well-characterized genomic disorder caused by 4p16.3 deletions. Wolf-Hirschhorn syndrome patients exhibit...
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Tandem histone methyltransferase upregulation defines a unique aggressive prostate cancer phenotype
BackgroundHistone modifications alter transcriptional gene function and participate in cancer progression. Enhancer-of-Zeste-Homologue-2 ( EZH2 ) and...
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Histone Mutations and Bone Cancers
Primary bone tumors are rare cancers that cause significant morbidity and mortality. The recent identification of recurrent mutations in histone...
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Histone methyltransferase NSD2 mediates the survival and invasion of triple-negative breast cancer cells via stimulating ADAM9-EGFR-AKT signaling
Triple-negative breast cancer (TNBC) is a heterogeneous disease with a poor prognosis due to the lack of an effective targeted therapy. Histone...
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A genetic map of the chromatin regulators to drug response in cancer cells
BackgroundDiverse drug vulnerabilities owing to the Chromatin regulators (CRs) genetic interaction across various cancers, but the identification of...
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Gain-of-Function Variomics and Multi-omics Network Biology for Precision Medicine
Traditionally, disease causal mutations were thought to disrupt gene function. However, it becomes more clear that many deleterious mutations could...
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Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma
The historical lack of preclinical models reflecting the genetic heterogeneity of multiple myeloma (MM) hampers the advance of therapeutic...
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The RNA methyltransferase METTL16 enhances cholangiocarcinoma growth through PRDM15-mediated FGFR4 expression
BackgroundRNA N6-Methyladenosine (m6A) modification is implicated in the progression of human cancers including cholangiocarcinoma (CCA). METTL16 is...
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N6-methyladenosine methylation in kidney injury
Multiple mechanisms are involved in kidney damage, among which the role of epigenetic modifications in the occurrence and development of kidney...
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Target validation and structure-based virtual screening to Discover potential lead molecules against the oncogenic NSD1 histone methyltransferase
The aim of the study was to validate Nuclear receptor-binding SET Domain NSD1 as a cancer drug target followed by the design of lead molecules...
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Ultrafast prediction of somatic structural variations by filtering out reads matched to pan-genome k-mer sets
Variant callers typically produce massive numbers of false positives for structural variations, such as cancer-relevant copy-number alterations and...
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Structural variants shape the genomic landscape and clinical outcome of multiple myeloma
Deciphering genomic architecture is key to identifying novel disease drivers and understanding the mechanisms underlying myeloma initiation and...
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Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer
Local adaptation directs populations towards environment-specific fitness maxima through acquisition of positively selected traits. However, rapid...
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De novo truncating variant in NSD2gene leading to atypical Wolf-Hirschhorn syndrome phenotype
BackgroundWolf-Hirschhorn syndrome (WHS) is a contiguous gene syndrome caused by partial 4p deletion highly variable in size in individual patients....
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The role of histone H3 lysine demethylases in glioblastoma
Glioblastoma (GBM) is the most aggressive primary brain tumor in adults with an average survival of 15–18 months. Part of its malignancy derives from...
