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Activation of NOP receptor increases vulnerability to stress: role of glucocorticoids and CRF signaling
RationaleRecently, we demonstrated that the activation of the nociceptin/orphanin FQ (N/OFQ) receptor (NOP) signaling facilitates depressive-like...
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Regulation of N-type calcium channels by nociceptin receptors and its possible role in neurological disorders
Activation of nociceptin opioid peptide receptors (NOP, a.k.a. opioid-like receptor-1, ORL-1) by the ligand nociceptin/orphanin FQ, leads to G...
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Structure-Based SAR in the Design of Selective or Bifunctional Nociceptin (NOP) Receptor Agonists
The nociceptin opioid receptor (NOP), the fourth member of the opioid receptor family, and its endogenous peptide ligand, nociceptin or orphanin FQ...
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The Foundational Science of Endogenous Opioids and Their Receptors
The function of endogenous opioids spans from initiating behaviors that are critical for survival, to responding to rapidly changing environmental...
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Neuromodulation in Parkinson’s disease targeting opioid and cannabinoid receptors, understanding the role of NLRP3 pathway: a novel therapeutic approach
Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia...
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Atypical chemokine receptors in the immune system
Leukocyte migration is a fundamental component of innate and adaptive immune responses as it governs the recruitment and localization of these motile...
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Effects of Non-Opiate Analogue of Leu-Enkephalin on the Ion Currents, Number of Nucleoli, and p53 Expression in Isolated Cardiomyocytes of Albino Rats
Acute exposure of isolated ventricular cardiomyocytes to non-opiate analogue of leu-enkephalin (NALE peptide: Phe-D-Ala-Gly-Phe-Leu-Arg) in a...
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Opioid Receptors and Neuronal Signal Transduction
This chapter provides information on the classification, structure, and properties of the main opioidOpioids receptor subtypes, their canonical and...
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Opioid Peptides and Their Receptors
Since the discovery of opioid receptors and their endogenous ligands named opioid peptides, it has been established that opiates exert their effects...
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Opioid Peptides and Their Receptors
Since the discovery of opioid receptors and their endogenous ligands named opioid peptides, it has been established that opiates exert their effects...
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Fear expression is reduced after acute and repeated nociceptin/orphanin FQ (NOP) receptor antagonism in rats: therapeutic implications for traumatic stress exposure
RationaleEvaluation of pharmacotherapies for acute stress disorder (ASD) or post-traumatic stress disorder (PTSD) is challenging due to robust...
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Evolution and challenges of opioids in pain management: Understanding mechanisms and exploring strategies for safer analgesics
Opioids traced back to ancient civilizations, have evolved in their usage for acute and chronic pain treatment. Their interaction with the endogenous...
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Involvement of the nociceptin opioid peptide receptor in morphine-induced antinociception, tolerance and physical dependence in female mice
Nociceptin opioid peptide (NOP) receptor modulates pain transmission and is considered a prospective target for pain management. Under acute pain...
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Natural compounds targeting nuclear receptors for effective cancer therapy
Human nuclear receptors (NRs) are a family of forty-eight transcription factors that modulate gene expression both spatially and temporally. Numerous...
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NOP Receptor Signaling Cascades
The nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor is a G protein-coupled receptor with wide distribution throughout the peripheral and...
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NOP-Targeted Nonpeptide Ligands
The development of nonpeptide systemically active small-molecule NOP-targeted ligands has contributed tremendously to validating the NOP receptor as...
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Interactions Between Endogenous Opioids and the Immune System
The endogenous opioid system, which consists of opioid receptors and their ligands, is widely expressed in the nervous system and also found in the...
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Cebranopadol: A Novel First-in-Class Potent Analgesic Acting via NOP and Opioid Receptors
Cebranopadol is a novel first-in-class analgesic with highly potent agonistic activity at nociceptin/orphanin FQ peptide (NOP) and opioid receptors....
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NOP-Related Mechanisms in Substance Use Disorders
Nociceptin/orphanin FQ (N/OFQ) is a 17 amino acid peptide that was deorphanized in 1995 and has been widely studied since. The role of the N/OFQ...
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Effects of NOP-Related Ligands in Nonhuman Primates
The nociceptin/orphanin FQ peptide (NOP) receptor-related ligands have been demonstrated in preclinical studies for several therapeutic applications....