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No association between peripheral serotonin-gene-related DNA methylation and brain serotonin neurotransmission in the healthy and depressed state
BackgroundMethylation of serotonin-related genes has been proposed as a plausible gene-by-environment link which may mediate environmental stress,...
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Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2D6, CYP2C19 and non-SSRI/non-TCA antidepressants
The Dutch Pharmacogenetics Working Group (DPWG) aims to facilitate pharmacogenetics implementation in clinical practice by develo** evidence-based...
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Impact of the circadian nuclear receptor REV-ERBα in dorsal raphe 5-HT neurons on social interaction behavior, especially social preference
Social interaction among conspecifics is essential for maintaining adaptive, cooperative, and social behaviors, along with survival among mammals....
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Mood and behavior regulation: interaction of lithium and dopaminergic system
Lithium is one of the most effect mood-stabilizing drugs prescribed especially for bipolar disorder. Lithium has wide range effects on different...
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Interaction between childhood trauma experience and TPH2 rs7305115 gene polymorphism in brain gray matter volume
BackgroundChildhood trauma is one of the most extensively studied and well-supported environmental risk factors for the development of mental health...
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Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2C19 and CYP2D6 and SSRIs
The Dutch Pharmacogenetics Working Group (DPWG) guideline presented here, presents the gene-drug interaction between the genes CYP2C19 and CYP2D6 and...
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Serotonergic gene-to-gene interaction is associated with mood and GABA concentrations but not with pain-related cerebral processing in fibromyalgia subjects and healthy controls
The neurotransmitter serotonin, involved in the regulation of pain and emotion, is critically regulated by the 5‐HT 1A autoreceptor and the serotonin...
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Interaction effect of crocin and citalopram on memory and locomotor activity in rats: an insight into BDNF and synaptophysin levels in the hippocampus
Selective serotonin reuptake inhibitors (SSRIs) are widely used drugs for the treatment of depression. Citalopram is one of the most prescribed SSRIs...
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Microbe–Host Metabolic Interaction: Probiotic Approach
Over 70% of human immune system resides in the gut, yet, these gut microbiomes not only regulate intestinal immune system but also influence the...
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Integrated network pharmacology analysis and experimental validation to investigate the mechanism of Flavan-3-ols and aromatic resins in depression
The present investigation delved into the pharmacological mechanisms underlying the management of depression through Flavan-3-ols and Aromatic Resins,...
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Drug interaction alerts in older primary care patients, and related medically justified actions
PurposeTo describe presented interaction alerts in older patients, and the extent to which these require further medical action for the specific...
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Pharmacokinetic Interaction Between Imatinib and Metformin in Rats
Background and ObjectiveImatinib is primarily transported into the liver by organic cation transporter 1 (OCT1), organic anion transporting...
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Drug-drug interaction perpetrators of oxycodone in patients with cancer: frequency and clinical relevance
AimOxycodone is known to have numerous drug-drug interactions (DDIs) that can potentially decrease efficacy or lead to adverse drug reactions (ADRs)....
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Glial-Neuronal Interaction in Synapses: A Possible Mechanism of the Pathophysiology of Bipolar Disorder
Bipolar disorder (BD) is a severe and chronic psychiatric disorder that affects approximately 1–4% of the world population and is characterized by...
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Prenatal exposure to valproic acid alters Reelin, NGF expressing neuron architecture and impairs social interaction in their autistic-like phenotype male offspring
Maternal exposure to anti-epileptic drug Valproic acid (VPA) during pregnancy increases the risk for the development of autism spectrum disorders...
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Neuron-Microglia Interaction is Involved in Anti-inflammatory Response by Vagus Nerve Stimulation in the Prefrontal Cortex of Rats Injected with Polyinosinic:Polycytidylic Acid
Injection of polyinosinic:polycytidylic acid (poly(I:C)) into experimental animals induces neuroimmunological responses and thus has been used for...
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Kv3.1 Interaction with UBR5 Is Required for Chronic Inflammatory Pain
Chronic inflammatory pain caused by neuronal hyperactivity is a common and refractory disease. Kv3.1, a member of the Kv3 family of voltage-dependent...
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Sex influences the effects of social status on socioemotional behavior and serotonin neurochemistry in rhesus monkeys
BackgroundDespite observed sex differences in the prevalence of stress-related psychiatric conditions, most preclinical and translational studies...
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Linking Inflammation, Aberrant Glutamate-Dopamine Interaction, and Post-synaptic Changes: Translational Relevance for Schizophrenia and Antipsychotic Treatment: a Systematic Review
Evidence from clinical, preclinical, and post-mortem studies supports the inflammatory/immune hypothesis of schizophrenia pathogenesis. Less evident...
