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NMDA Receptors Methods and Protocols
This fully updated volume explores N-Methyl-D-aspartate receptors (NMDARs), and the structure-function relations, principles, and rules that govern...
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Selective Cell-Surface Expression of Triheteromeric NMDA Receptors
NMDA-type ionotropic glutamate receptors are critically involved in many brain functions and are implicated in a variety of brain disorders. Seven...
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Analysis of Functional NMDA Receptors in Astrocytes
Neuronal N-methyl-D-aspartate (NMDA) receptors are well known for their pivotal role in memory formation. Originally, they were thought to be...
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Single-Molecule FRET Analyses of NMDA Receptors
Single-molecule fluorescence resonance energy transfer (smFRET) enables the real-time observation of conformational changes in a single protein...
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Estimating the Ca2+ Block of NMDA Receptors with Single-Channel Electrophysiology
In vertebrate central neurons, NMDA receptors are glutamate- and glycine-gated ion channels that allow the passage of Na+ and Ca2+ ions into the cell...
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Estimating the Ca2+ Permeability of NMDA Receptors with Whole-Cell Patch-Clamp Electrophysiology
In the mammalian central nervous system (CNS), fast excitatory transmission relies primarily on the ionic fluxes generated by ionotropic glutamate...
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Cellular mechanisms of contextual fear memory reconsolidation: Role of hippocampal SFKs, TrkB receptors and GluN2B-containing NMDA receptors
Memories are stored into long-term representations through a process that depends on protein synthesis. However, a consolidated memory is not static...
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Role of NMDA receptors blockade in the thalamic paraventricular nucleus in morphine dependent rat model of formalin-induced pain
Evidence shows that the N-methyl- d -aspartate (NMDA) antagonist MK801 reduces the development of morphine (Mor) tolerance. The paraventricular nucleus...
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The Effects of Piracetam and Noopept on NMDA- and 5-HT2A-Receptors in the Brains of Mice with Congenital β-Arrestin Deficiency
Abstract —Based on the special role of the β-arrestin signal protein in the processes of neuronal plasticity and receptor activation, the effects of...
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Ginger (Zingiber Officinale Roscoe) ameliorates ethanol-induced cognitive impairment by modulating NMDA and GABA-A receptors in rat hippocampus
Brain damage caused by ethanol abuse may lead to permanent damage, including severe dementia. The aim of this study was to investigate the effects of...
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Progresses in GluN2A-containing NMDA Receptors and their Selective Regulators
NMDA receptors play an important physiological role in regulating synaptic plasticity, learning and memory. GluN2A subunits are the most abundant...
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Activation of NMDA receptors in brain endothelial cells increases transcellular permeability
Neurovascular coupling is a precise mechanism that induces increased blood flow to activated brain regions, thereby providing oxygen and glucose. In...
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Expression and Purification of Mammalian NMDA Receptor Protein for Functional Characterization
N-methyl-D-aspartate (NMDA) receptors are critical for brain function and serve as drug targets for the treatment of neurological and psychiatric...
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Ameliorative Effect of Cannabidiol on Topiramate-Induced Memory Loss: The Role of Hippocampal and Prefrontal Cortical NMDA Receptors and CREB/BDNF Signaling Pathways in Rats
Cannabidiol (CBD) is a promising neurological agent with potential beneficial effects on memory and cognitive function. The combination of CBD and...
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NMDA Glutamate Receptor Expression Activity in Anaplastic Astrocytomas
Objectives . To study the relationship between the expression activity of NMDA glutamate receptors and the proliferative activity and genetic...
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N-Methyl-D-aspartate (NMDA) and cannabinoid CB2 receptors form functional complexes in cells of the central nervous system: insights into the therapeutic potential of neuronal and microglial NMDA receptors
BackgroundThe cannabinoid CB 2 receptor (CB 2 R), which is a target to afford neuroprotection, and N-methyl-D-aspartate (NMDA) ionotropic glutamate...
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Limb-Clas** Response in NMDA Receptor Palmitoylation-Deficient Mice
Proper regulation of N -methyl- d -aspartate-type glutamate receptor (NMDA receptor) expression is responsible for excitatory synaptic functions in the...
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Hyperammonemia Alters the Function of AMPA and NMDA Receptors in Hippocampus: Extracellular cGMP Reverses Some of These Alterations
Chronic hyperammonemia alters membrane expression of AMPA and NMDA receptors subunits in hippocampus leading to impaired memory and learning....
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Hippocampus-Dependent Learning Deficit Does Not Correlate with Suppression of Long-Term Post-Tetanic Potentiation by Systemic Blockade of NMDA Receptors
Learning and behavior were more sensitive than LTP-like plasticity to blockade of NMDA receptors (NMDAr). I.p. and intraventricular injections of...