Search
Search Results
-
NLRP inflammasomes in health and disease
NLRP inflammasomes are a group of cytosolic multiprotein oligomer pattern recognition receptors (PRRs) involved in the recognition of...
-
Mechanistic insights from inflammasome structures
Inflammasomes are supramolecular complexes that form in the cytosol in response to pathogen-associated and damage-associated stimuli, as well as...
-
Linking NLRP3 inflammasome and pulmonary fibrosis: mechanistic insights and promising therapeutic avenues
Pulmonary fibrosis is a devastating disorder distinguished by redundant inflammation and matrix accumulation in the lung interstitium. The early...
-
Mitochondrial damage activates the NLRP10 inflammasome
Upon detecting pathogens or cell stress, several NOD-like receptors (NLRs) form inflammasome complexes with the adapter ASC and caspase-1, inducing...
-
Elucidating the Role of miRNA in Inflammasome-Mediated Immune Response in Leishmaniasis
The inflammasome is a cell cytoplasm-localized multimeric protein complex of host defense mechanism which gets activated due to infection in the...
-
VCP Inhibition Augments NLRP3 Inflammasome Activation
Lysosomal membrane permeabilization caused either via phagocytosis of particulates or the uptake of protein aggregates can trigger the activation of...
-
Insights into inflammasome regulation: cellular, molecular, and pathogenic control of inflammasome activation
Maintenance of immune homeostasis is an intricate process wherein inflammasomes play a pivotal role by contributing to innate and adaptive immune...
-
KSHV-encoded ORF45 activates human NLRP1 inflammasome
At steady state, the NOD-like receptor (NLR)-containing pyrin domain (PYD) (NLRP)1 inflammasome is maintained in an auto-inhibitory complex by...
-
Inflammasome functional activities in B lymphocytes
Studies in animal models and human subjects have shown that, in addition to their implication in innate immunity, inflammasomes also can play a role...
-
NLRP3 inflammasome: a key player in the pathogenesis of life-style disorders
Proinflammatory cytokines and chemokines play a crucial role in regulating the inflammatory response, which is essential for the proper functioning...
-
Toll-like Receptor 2-Melatonin Feedback Loop Regulates the Activation of Spinal NLRP3 Inflammasome in Morphine-Tolerant Rats
Background and Purpose: Morphine is amongst the most effective analgesics available for the management of severe pain. However, prolonged morphine...
-
Inflammasome Activation Mediates Apoptotic and Pyroptotic Death in Astrocytes Under Ischemic Conditions
Inflammation is a hallmark mechanism of ischemic stroke-induced brain injury. Recent studies have shown that an intracellular multimeric protein...
-
NLRP3 inflammasome in cognitive impairment and pharmacological properties of its inhibitors
Cognitive impairment is a multifactorial and multi-step pathological process that places a heavy burden on patients and the society....
-
Roundup® induces premature senescence of mouse granulosa cells via mitochondrial ROS-triggered NLRP3 inflammasome activation
Roundup, a glyphosate-based herbicide widely used in agriculture, has raised concerns regarding its potential impact on human health due to the...
-
New Insights on NLRP3 Inflammasome: Mechanisms of Activation, Inhibition, and Epigenetic Regulation
AbstractInflammasomes are important modulators of inflammation. Dysregulation of inflammasomes can enhance vulnerability to conditions such as...
-
Fisetin mitigates letrozole-induced polycystic ovarian syndrome in rats: crosstalk of AMPK/PI3K/AKT-mediated-Nrf2 antioxidant defense mechanism and the inflammasome NLRP3/NF-κB P65/IL-1β signaling pathways
Polycystic ovarian syndrome (PCOS) is a highly prevalent condition affecting reproductive-aged women, causing insulin resistance, hyperandrogenism,...
-
Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation
Unlike other nucleotide oligomerization domain-like receptors, Nlrp10 lacks a canonical leucine-rich repeat domain, suggesting that it is incapable...
-
Expression and Purification of Inflammasome Sensor NOD-Like Receptor Protein-1 Using the Baculovirus-Insect Cell Expression System
Inflammasomes are innate immune sensing and signaling complexes critical for defense against pathogens and response to cellular stresses. A core...
-
Ameliorative effect of montelukast against STZ induced diabetic nephropathy: targeting HMGB1, TLR4, NF-κB, NLRP3 inflammasome, and autophagy pathways
Diabetic nephropathy (DN) is reported as one of the most serious microvascular diabetic complications and the trigger of end-stage renal disease...
-
Cardioprotective role of diacerein in diabetic cardiomyopathy via modulation of inflammasome/caspase1/interleukin1β pathway in juvenile rats
Diabetes mellitus is a common metabolic disorder affecting different body organs; one of its serious complications is diabetic cardiomyopathy (DCM)....
