Search
Search Results
-
Hsa_circ_0009092/miR-665/NLK signaling axis suppresses colorectal cancer progression via recruiting TAMs in the tumor microenvironment
BackgroundIt has been demonstrated that circularRNA (circRNAs) plays a critical role in various cancers. While the potential molecular mechanism of...
-
Identification of diagnostic markers related to inflammatory response and cellular senescence in endometriosis using machine learning and in vitro experiment
ObjectiveTo understand the association between chronic inflammation, cellular senescence, and immunological infiltration in endometriosis.
...
-
Somatic Mutations and Intratumoral Heterogeneity of Cancer-Related Genes NLK, YY1 and PA2G4 in Gastric and Colorectal Cancers
Many genes act as both tumor suppressor gene (TSG) and proto-oncogene depending on cellular context and cancer type. Nemo-like kinase ( NLK) encoding...
-
Cerebrospinal fluid levels of the neurotrophic factor neuroleukin are increased in early Alzheimer’s disease, but not in cerebral amyloid angiopathy
BackgroundNeuroleukin (NLK) is a protein with neurotrophic properties and is present in a proportion of senile plaques and amyloid laden vessels. It...
-
Cerebrospinal fluid monocyte chemoattractant protein 1 correlates with progression of Parkinson’s disease
Parkinson’s disease (PD) and multiple system atrophy (MSA) have overlap** symptoms, challenging a correct early diagnosis. Prognostic information...
-
-
Data-driven identification and classification of nonlinear aging patterns reveals the landscape of associations between DNA methylation and aging
BackgroundAging affects the incidence of diseases such as cancer and dementia, so the development of biomarkers for aging is an important research...
-
The mediating effect of DNA methylation in the association between maternal sleep during pregnancy and offspring adiposity status: a prospective cohort study
BackgroundChildhood overweight/obesity is a global public health concern. It is important to identify its early-life risk factors. Maternal poor...
-
Comprehensive Analysis Based on the TCGA Database Identified SCIN as a Key DNA Methylation-Driver Gene in Epstein-Barr Virus-Associated Gastric Cancer
An important feature of EBV-associated gastric cancer (EBVaGC) is extensive methylation of viral and host genomes. This study aims to analyze DNA...
-
Deciphering the role of miR-71 and let-7 in the fertility of cystic echinococcosis cysts: a preliminary assessment
Cystic echinococcosis (CE) is a neglected helminthic zoonosis in many parts of the world. Some CE cysts in the intermediate host are non-fertile....
-
Integrative functional genomic analyses identify genetic variants influencing skin pigmentation in Africans
Skin color is highly variable in Africans, yet little is known about the underlying molecular mechanism. Here we applied massively parallel reporter...
-
Current Insights into Signature MicroRNA Networks and Signal Transduction in Osteosarcoma
Purpose of ReviewOsteosarcoma is one of the most common types of primary bone tumors that mainly occurs in children and adolescents. It is...
-
Esculetin releases maturation arrest and induces terminal differentiation in leukemic blast cells by altering the Wnt signaling axes
BackgroundThe “Differentiation therapy” has been emerging as a promising and more effective strategy against acute leukemia relapses.
...
-
The biology of YAP in programmed cell death
In the last few decades, YAP has been shown to be critical in regulating tumor progression. YAP activity can be regulated by many kinase cascade...
-
Dynamics of Drug Resistance
Drug resistance is an aspect of tumour progression, and is thus common in advanced tumours. Because drug resistance is readily measurable in...
-
Urinary extracellular vesicle as a potential biomarker of exercise-induced fatigue in young adult males
PurposePrevious studies have suggested that circulating extracellular vesicles (EVs) arise after high intensity exercise and urine could reflect the...
-
Insights into recent findings and clinical application of YAP and TAZ in cancer
Decades of research have mapped out the basic mechanics of the Hippo pathway. The paralogues Yes-associated protein (YAP) and transcriptional...
-
Roles of HOTAIR Long Non-coding RNA in Gliomas and Other CNS Disorders
HOX transcript antisense intergenic RNA ( HOTAIR ) is a long non-coding RNA (lncRNA) which is increasingly being perceived as a tremendous molecular...
-
Wnt Signaling in Cancer
Stringent regulation of the Wnt pathways components and modulators is indispensable for the restoration of tissue homeostasis and development. The...
-
Targeted design and identification of AC1NOD4Q to block activity of HOTAIR by abrogating the scaffold interaction with EZH2
BackgroundNearly 25% of long intergenic non-coding RNAs (lincRNAs) recruit chromatin-modifying proteins (e.g., EZH2) to silence target genes. HOX...
