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Different waves of postglacial recolonisation and genomic structure of bank vole populations in NE Poland
Previous studies indicated that in some species phylogeographic patterns obtained in the analysis of nuclear and mitochondrial DNA (mtDNA) markers...
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Primaquine Loaded Solid Lipid Nanoparticles (SLN), Nanostructured Lipid Carriers (NLC), and Nanoemulsion (NE): Effect of Lipid Matrix and Surfactant on Drug Entrapment, in vitro Release, and ex vivo Hemolysis
Primaquine (PQ), an 8-aminoquinoline antimalarial drug, has been widely used for the eradication of hypnozoites from the liver and, therefore,...
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Urinary neopterin and biopterin indicate that inflammation has a role in autism spectrum disorder
Inflammation is thought to be involved in the pathogenesis of autism spectrum disorder (ASD). Pteridine metabolites are biomarkers of inflammation...
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Enhanced Oral Bioavailability of Isoformononetin Through Nanoemulsion: Development, Optimization, and Characterization
BackgroundIsoformononetin (IFN) is a methoxyl derivative of daidzein and has been stated as a potent osteogenic isoflavone. However, IFN has low oral...
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Sleep features of nocturnal enuresis: relationship between rapid eye movement sleep latency prolongation and nocturnal enuresis
Nocturnal enuresis, or bed wetting, is the involuntary urination during sleep. One of its causes is difficulty awakening during sleep, suggesting a...
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Exploring the predictive power of jejunal microbiome composition in clinical and subclinical necrotic enteritis caused by Clostridium perfringens: insights from a broiler chicken model
BackgroundNecrotic enteritis (NE) is a severe intestinal infection that affects both humans and poultry. It is caused by the bacterium Clostridium...
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Voltammetry in the spleen assesses real-time immunomodulatory norepinephrine release elicited by autonomic neurostimulation
BackgroundThe noradrenergic innervation of the spleen is implicated in the autonomic control of inflammation and has been the target of...
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Clove volatile oil-loaded nanoemulsion reduces the anxious-like behavior in adult zebrafish
BackgroundClove volatile oil (CVO) and its major compound, eugenol (EUG), have anxiolytic effects, but their clinical use has been impaired due to...
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Enhancing transmucosal delivery of CBD through nanoemulsion: in vitro and in vivo studies
Cannabidiol (CBD) has gained significant attention as a complementary and alternative medicine due to its promising therapeutic properties. However,...
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The first case of autochthonous subcutaneous dirofilariasis (Dirofilaria repens) in a dog from Białowieża (NE Poland) and possible threat posed to inhabitants of Białowieża Primeval Forest area
We present the first case of dirofilariasis in a dog from Białowieża village located in the primeval European forest—Białowieża Primeval Forest (NE...
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Intact NMR Approach Quickly Reveals Synchronized Microstructural Changes in Oil-in-Water Nanoemulsion Formulations
A soft-core oil-in-water (o/w) nanoemulsion (NE) is composed of nanometer (nm) sized oil droplets, stabilized by a surfactant layer and dispersed in...
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QbD Enabled Formulation Development of Nanoemulsion of Nimodipine for Improved Biopharmaceutical Performance
PurposeThe objective of the current research is to formulate a nanoemulsion (NE) of nimodipine (ND) to improve its oral bioavailability and stability...
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Neutrophils disrupt B-1a cell homeostasis by targeting Siglec-G to exacerbate sepsis
B-1a cells, an innate-like cell population, are crucial for pathogen defense and the regulation of inflammation through their release of natural IgM...
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Noradrenergic modulation of play in Sprague-Dawley and F344 rats
RationaleFor many mammals, engaging in social play behavior as a juvenile is important for cognitive, social, and emotional health as an adult. A...
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Nanoemulsions and nanocapsules loaded with Melaleuca alternifolia essential oil for sepsis treatment
Sepsis represents a complex clinical syndrome that results from a harmful host response to infection. The infections most associated with sepsis are...
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Prophylactic norepinephrine combined with 6% hydroxyethyl starch (130/0.4) co-load infusion for preventing postspinal anesthesia hypotension during cesarean section: a randomized, controlled, dose-finding trial
PurposeColloid and/or co-load may be more effective than crystalloid for preventing postspinal anesthesia hypotension. We tested five different...
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Influence of body composition and cardiorespiratory fitness on plasma HSP72, norepinephrine, insulin, and glucose responses to an acute aerobic exercise bout performed in the fed state
Being overweight is already considered a metabolic risk factor, which can be overcome by increasing cardiorespiratory fitness (CRF). Acute exercise...
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Association of admission neutrophil serine proteinases levels with the outcomes of acute ischemic stroke: a prospective cohort study
BackgroundNeutrophil serine proteinases (NSPs), released by activated neutrophils, are key proteins involved in the pathophysiologic processes of...
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Multicomponent intranasal adjuvant for mucosal and durable systemic SARS-CoV-2 immunity in young and aged mice
Multiple FDA-approved SARS-CoV-2 vaccines currently provide excellent protection against severe disease. Despite this, immunity can wane relatively...
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Subacute Exposure to Gaseous Pollutants from Diesel Engine Exhaust Attenuates Capsaicin-Induced Cardio-Pulmonary Reflex Responses Involving Oxidant Stress Mechanisms in Adult Wistar Rats
Intravenous injection of capsaicin produces vagal-mediated protective cardio-pulmonary (CP) reflexes manifesting as tachypnea, bradycardia, and...
