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ANKRD49 promotes the metastasis of NSCLC via activating JNK-ATF2/c-Jun-MMP-2/9 axis
BackgroundAnkyrin repeat domain 49 (ANKRD49) has been found to be highly expressed in multiple cancer including lung adenocarcinoma (LUAD) and lung...
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Role of integrin α2 in methotrexate-induced epithelial-mesenchymal transition in alveolar epithelial A549 cells
Methotrexate (MTX) is widely used to treat various diseases. However, it induces adverse reactions like serious lung injury, including pulmonary...
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Non B Cell-Derived Immunoglobulins in Lung Epithelial Cells and Lung Cancer
As the locus for air exchange, lung tissue is perpetually exposed to a significant quantity of foreign pathogens. Consequently, lung has developed a...
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Solid dispersion of mebendazole via surfactant carrier to improve oral bioavailability and in vitro anticancer efficacy
PurposeThis study aimed to prepare a solid dispersion (SD) formulation of MBZ to improve dissolution and oral bioavailability.
Methods ...
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Pulsatilla saponin D regulates ras-related C3 botulinum toxin substrate 3 (RAC3) to overcome resistance to paclitaxel in lung adenocarcinoma cells
BackgroundPaclitaxel, a tubulin-binding agent, is a Food and Drug Administration-approved first-line drug for the treatment of non-small cell lung...
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Serine synthesis and catabolism in starved lung cancer and primary bronchial epithelial cells
Serine and glycine give rise to important building blocks in proliferating cells. Both amino acids are either synthesized de novo or taken up from...
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LncRNA AL139294.1 can be transported by extracellular vesicles to promote the oncogenic behaviour of recipient cells through activation of the Wnt and NF-κB2 pathways in non-small-cell lung cancer
BackgroundExtracellular vesicles (EVs) participate in cancer development via cell-to-cell communication. Long non-coding RNAs (lncRNAs), one...
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Synthesis and antitumor activity of novel silibinin and 2,3-dehydrosilybin derivatives with carbamate groups
A novel series of silibinin and 2,3-dehydrosilybin derivatives bearing carbamate groups were designed, synthesized and their in vitro anticancer...
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Triptolide suppresses the growth and metastasis of non-small cell lung cancer by inhibiting β-catenin-mediated epithelial–mesenchymal transition
Non-small cell lung cancer (NSCLC) is characterized by a high incidence of metastasis and poor survival. As epithelial–mesenchymal transition (EMT)...
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Phenethyl isothiocyanate inhibits metastasis potential of non-small cell lung cancer cells through FTO mediated TLE1 m6A modification
N6-methyladenosine (m 6 A) modification is a prevalent RNA epigenetic modification, which plays a crucial role in tumor progression including...
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CYB5R3 functions as a tumor suppressor by inducing ER stress-mediated apoptosis in lung cancer cells via the PERK-ATF4 and IRE1α-JNK pathways
Cytochrome b5 reductase 3 (CYB5R3) is involved in various cellular metabolic processes, including fatty acid synthesis and drug metabolism. However,...
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Promoter methylation-regulated miR-148a-3p inhibits lung adenocarcinoma (LUAD) progression by targeting MAP3K9
Lung adenocarcinoma (LUAD) characterized by high metastasis and mortality is the leading subtype of non-small cell lung cancer. Evidence shows that...
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m6A methylation reader IGF2BP2 activates endothelial cells to promote angiogenesis and metastasis of lung adenocarcinoma
BackgroundLung adenocarcinoma (LUAD) is a common type of lung cancer with a high risk of metastasis, but the exact molecular mechanisms of metastasis...
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Targeting the key players of phenotypic plasticity in cancer cells by phytochemicals
Plasticity of phenotypic traits refers to an organism’s ability to change in response to environmental stimuli. As a result, the response may alter...
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PI3K/AKT pathway as a pivotal regulator of epithelial-mesenchymal transition in lung tumor cells
Lung cancer, as the leading cause of cancer related deaths, is one of the main global health challenges. Despite various progresses in diagnostic and...
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MicroRNAs as the critical regulators of autophagy-mediated cisplatin response in tumor cells
Chemotherapy is one of the most common therapeutic methods in advanced and metastatic tumors. Cisplatin (CDDP) is considered as one of the main...
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A dual role for ERK-1/2 in the regulation of plasmin activity and cell migration in metastatic NSCLC-H1299 cells
Occupational and environmental exposure of various toxins or cigarette smoke causes non-small cell lung carcinoma (NSCLC); a devastating disease with...
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Characterization of intrinsic and effective fitness changes caused by temporarily fixed mutations in the SARS-CoV-2 spike E484 epitope and identification of an epistatic precondition for the evolution of E484A in variant Omicron
BackgroundIntrinsic fitness costs are likely to have guided the selection of lineage-determining mutations during emergence of variants of...
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Antitumor effects of erlotinib in combination with berberine in A431 cells
BackgroundFirst-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as erlotinib, have been shown to target...
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Thyroid Hormones Shape the Fate of Cancer Cells and Antitumor Immune Responses
The activation of the innate and the adaptive immune responses contributes to the control and eradication of tumors. Natural killer cells and T...