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Circ2388 regulates myogenesis and muscle regeneration
The formation of skeletal muscle is a complex process that is coordinated by many regulatory factors, such as myogenic factors and noncoding RNAs....
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Myogenesis defects in a patient-derived iPSC model of hereditary GNE myopathy
Hereditary muscle diseases are disabling disorders lacking effective treatments. UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (GNE)...
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Immune-mediated myogenesis and acetylcholine receptor clustering promote a slow disease progression in ALS mouse models
BackgroundAmyotrophic lateral sclerosis (ALS) is a heterogeneous disease in terms of onset and progression rate. This may account for therapeutic...
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CPNE1 regulates myogenesis through the PERK-eIF2α pathway mediated by endoplasmic reticulum stress
Sarcopenia is characterized by a progressive reduction in muscle mass or muscle physiological function associated with aging, but the relevant...
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Dynamics of skeletal muscle-resident stem cells during myogenesis in fibrodysplasia ossificans progressiva
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease in which extraskeletal (heterotopic) bone forms within tissues such as skeletal...
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Age-dependent loss of Crls1 causes myopathy and skeletal muscle regeneration failure
Skeletal muscle aging results in the gradual suppression of myogenesis, leading to muscle mass loss. However, the specific role of cardiolipin in...
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The role of PDIA3 in myogenesis during muscle regeneration
Beta 3 (β3) integrin plays an important role in the initiation of myogenesis in adult muscle. Protein disulfide isomerases (PDIs) can activate β3...
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Extracellular matrix: the critical contributor to skeletal muscle regeneration—a comprehensive review
The regenerative ability of skeletal muscle (SM) in response to damage, injury, or disease is a highly intricate process that involves the...
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ALDH1A1 and ALDH1A3 paralogues of aldehyde dehydrogenase 1 control myogenic differentiation of skeletal muscle satellite cells by retinoic acid-dependent and -independent mechanisms
ALDH1A1 and ALDH1A3 paralogues of aldehyde dehydrogenase 1 (ALDH1) control myogenic differentiation of skeletal muscle satellite cells (SC) by...
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Review: myogenic and muscle toxicity targets of environmental methylmercury exposure
A number of environmental toxicants are noted for their activity that leads to declined motor function. However, the role of muscle as a proximal...
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Odd skipped-related 1 controls the pro-regenerative response of fibro-adipogenic progenitors
Skeletal muscle regeneration requires the coordinated interplay of diverse tissue-resident- and infiltrating cells. Fibro-adipogenic progenitors...
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Thyroid Hormones and Skeletal Muscle Beyond Thermogenesis
Thyroid hormones are widely studied for their involvement in energy metabolism and thermogenesis. However, their role on muscle fibers and the...
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Requirement for PINCH in skeletal myoblast differentiation
PINCH, an adaptor of focal adhesion complex, plays essential roles in multiple cellular processes and organogenesis. Here, we ablated PINCH1 or both...
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Dopamine receptor D4 (DRD4) negatively regulates UCP1- and ATP-dependent thermogenesis in 3T3-L1 adipocytes and C2C12 muscle cells
The activation of beige fat and muscle tissues is an interesting and encouraging target for therapeutic intervention in obesity owing to their...
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Homozygous loss-of-function variants in FILIP1 cause autosomal recessive arthrogryposis multiplex congenita with microcephaly
Arthrogryposis multiplex congenita forms a broad group of clinically and etiologically heterogeneous disorders characterized by congenital joint...
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Effect of miR-493-5p on proliferation and differentiation of myoblast by targeting ANKRD17
The hypertrophy and conversion of postnatal muscle fibers largely determine the yield and quality of meat, which is closely related to the economic...
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Integrated analysis identifies GABRB3 as a biomarker in prostate cancer
BackgroundTreatment failure following androgen deprivation therapy (ADT) presents a significant challenge in the management of advanced prostate...
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Regulation of satellite cells by exercise in hypoxic conditions: a narrative review
PurposeTo investigate in vivo the adaptations of satellite cell induced by exercise performed in acute or chronic hypoxic conditions and their...
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Exosome-mediated regulatory mechanisms in skeletal muscle: a narrative review
Skeletal muscle plays a paramount role in physical activity, metabolism, and energy balance, while its homeostasis is being challenged by multiple...