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Impact of stretch on sarcomere length variability in isolated fully relaxed rat cardiac myocytes
The contractility of cardiac muscle is greatly affected by preload via the Frank-Starling mechanism (FSM). It is based on preload-dependent...
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Protein carbonylation causes sarcoplasmic reticulum Ca2+ overload by increasing intracellular Na+ level in ventricular myocytes
Diabetes is commonly associated with an elevated level of reactive carbonyl species due to alteration of glucose and fatty acid metabolism. These...
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Adrenoceptor sub-type involvement in Ca2+ current stimulation by noradrenaline in human and rabbit atrial myocytes
Atrial fibrillation (AF) from elevated adrenergic activity may involve increased atrial L-type Ca 2+ current (I CaL ) by noradrenaline (NA). However,...
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Inhibition of late sodium current via PI3K/Akt signaling prevents cellular remodeling in tachypacing-induced HL-1 atrial myocytes
An aberrant late sodium current ( I Na,Late ) caused by a mutation in the cardiac sodium channel (Na v 1.5) has emerged as a contributor to electrical...
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Adiponectin overexpression in C2C12 myocytes increases lipid oxidation and myofiber transition
Metabolic syndrome and obesity have detrimental effects on the metabolic function of the skeletal muscle. Mounting evidence indicates that patients...
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Role of the T-Tubules in the Control of Cellular Calcium and Inotropic Interventions in Cardiac Ventricular Myocytes
The sarcolemma of mammalian cardiac ventricular myocytes contains a system of invaginations known as transverse (or t-) tubules that arise through...
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Conditional immortalization of human atrial myocytes for the generation of in vitro models of atrial fibrillation
The lack of a scalable and robust source of well-differentiated human atrial myocytes constrains the development of in vitro models of atrial...
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Ellagic Acid Prevents Ca2+ Dysregulation and Improves Functional Abnormalities of Ventricular Myocytes via Attenuation of Oxidative Stress in Pathological Cardiac Hypertrophy
The aim of this study was to investigate whether ellagic acid (EA) treatment can prevent changes in contractile function and Ca 2+ regulation of...
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Discordant Ca2+ release in cardiac myocytes: characterization and susceptibility to pharmacological RyR2 modulation
Systolic Ca 2+ transients are shaped by the concerted summation of Ca 2+ sparks across cardiomyocytes. At high pacing rates, alterations of...
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Rosuvastatin Reduces L-Type Ca2+ Current and Alters Contractile Function in Cardiac Myocytes via Modulation of β-Adrenergic Receptor Signaling
Rosuvastatin is one of the most used statins to lower plasma cholesterol levels. Although previous studies have reported remarkable cardiovascular...
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Cobalt oxide nanoparticles induce oxidative stress and alter electromechanical function in rat ventricular myocytes
BackgroundNanotoxicology is an increasingly relevant field and sound paradigms on how inhaled nanoparticles (NPs) interact with organs at the...
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Time-resolved transcriptional profiling of Trichinella-infected murine myocytes helps to elucidate host–pathogen interactions in the muscle stage
BackgroundParasites of the genus Trichinella are the pathogenic agents of trichinellosis, which is a widespread and severe foodborne parasitic...
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Inhibitory effects of aloperine on voltage-gated Na+ channels in rat ventricular myocytes
Aloperine (ALO), a quinolizidine alkaloid extracted from Sophora alopecuroides L., modulates hypertension, ventricular remodeling, and myocardial...
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CD44 regulates Epac1-mediated β-adrenergic-receptor-induced Ca2+-handling abnormalities: implication in cardiac arrhythmias
BackgroundSustained, chronic activation of β-adrenergic receptor (β-AR) signaling leads to cardiac arrhythmias, with exchange proteins directly...
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Atrial myocyte-derived exosomal microRNA contributes to atrial fibrosis in atrial fibrillation
BackgroundAtrial fibrosis plays a critical role in the development of atrial fibrillation (AF). Exosomes are a promising cell-free therapeutic...
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Selective SERCA2a activator as a candidate for chronic heart failure therapy
BackgroundThe sarcoplasmic reticulum (SR) Ca 2+ ATPase (SERCA2a) depression substantially contributes to diastolic dysfunction in heart failure (HF),...
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Targeting NLRP3 signaling reduces myocarditis-induced arrhythmogenesis and cardiac remodeling
BackgroundMyocarditis substantially increases the risk of ventricular arrhythmia. Approximately 30% of all ventricular arrhythmia cases in patients...
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Minimal contribution of IP3R2 in cardiac differentiation and derived ventricular-like myocytes from human embryonic stem cells
Type 2 inositol 1,4,5-trisphosphate receptor (IP 3 R2) regulates the intracellular Ca 2+ release from endoplasmic reticulum in human embryonic stem...
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Calmodulin Kinase II Regulation of Heart Rhythm and Disease
Calmodulin kinase II (CaMKII) is expressed in tissues throughout the body with essential roles in a wide variety of cellular functions from synaptic...