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Acrylamide, Applied During Pregnancy and Postpartum Period in Offspring Rats, Significantly Disrupted Myelination by Decreasing the Levels of Myelin-Related Proteins: MBP, MAG, and MOG
Acrylamide (ACR) is a colorless, odorless, and water-soluble solid molecule. In addition to being an important industrial material, ACR is found in...
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Dynamics of mature myelin
Myelin, which is produced by oligodendrocytes, insulates axons to facilitate rapid and efficient action potential propagation in the central nervous...
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Myelin in Alzheimer’s disease: culprit or bystander?
Alzheimer’s disease (AD) is a neurodegenerative disorder with neuronal and synaptic losses due to the accumulation of toxic amyloid β (Αβ) peptide...
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Deletion of CD47 from Schwann cells and macrophages hastens myelin disruption/dismantling and scavenging in Schwann cells and augments myelin debris phagocytosis in macrophages
BackgroundMyelin that surrounds axons breaks in trauma and disease; e.g., peripheral nerve and spinal cord injuries (PNI and SCI) and multiple...
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Myelin Imaging
Central myelin is an envelope composed of dozens of superimposed layers of the plasma membrane of oligodendrocytes around the neural axons. This...
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Quantifying myelin density in the feline auditory cortex
The cerebral cortex comprises many distinct regions that differ in structure, function, and patterns of connectivity. Current approaches to...
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Microglia regulation of central nervous system myelin health and regeneration
Microglia are resident macrophages of the central nervous system that have key functions in its development, homeostasis and response to damage and...
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Effects of Curcumin on Axon Growth and Myelin Sheath Formation in an In Vitro Model
Although the beneficial effects of curcumin, extracted from rhizomes of the ginger family genus Curcuma , on the repair and regeneration of nerves...
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The aminosteroid U73122 promotes oligodendrocytes generation and myelin formation
Oligodendrocytes (OLs) are glial cells that ensheath neuronal axons and form myelin in the central nervous system (CNS). OLs are differentiated from...
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Influenza A virus infection disrupts oligodendrocyte homeostasis and alters the myelin lipidome in the adult mouse
BackgroundRecent data suggest that myelin may be altered by physiological events occurring outside of the central nervous system, which may cause...
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T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis
Age-related myelin damage induces inflammatory responses, yet its involvement in Alzheimer’s disease remains uncertain, despite age being a major...
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Mertk-expressing microglia influence oligodendrogenesis and myelin modelling in the CNS
BackgroundMicroglia, an immune cell found exclusively within the CNS, initially develop from haematopoietic stem cell precursors in the yolk sac and...
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Janus Kinase Inhibitor Brepocitinib Rescues Myelin Phagocytosis Under Inflammatory Conditions: In Vitro Evidence from Microglia and Macrophage Cell Lines
Central nervous system (CNS) injuries induce cell death and consequently the release of myelin and other cellular debris. Microglia as well as...
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Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease
Axonal degeneration determines the clinical outcome of multiple sclerosis and is thought to result from exposure of denuded axons to immune-mediated...
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LMP2 deficiency causes abnormal metabolism, oxidative stress, neuroinflammation, myelin loss and neurobehavioral dysfunctions
BackgroundSubstantial evidence suggests that immunoproteasome is implicated in the various neurological diseases such as stroke, multiple sclerosis...
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Trametinib, an anti-tumor drug, promotes oligodendrocytes generation and myelin formation
Oligodendrocytes (OLs) are differentiated from oligodendrocyte precursor cells (OPCs) in the central nervous system (CNS). Demyelination is a common...
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Protein citrullination marks myelin protein aggregation and disease progression in mouse ALS models
Increased protein citrullination (PC) and dysregulated protein arginine deiminase (PAD) activity have been observed in several neurodegenerative...
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Myelin repair in Alzheimer’s disease: a review of biological pathways and potential therapeutics
This literature review investigates the significant overlap between myelin-repair signaling pathways and pathways known to contribute to hallmark...
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Myeloid cell-associated aromatic amino acid metabolism facilitates CNS myelin regeneration
Regulation of myeloid cell activity is critical for successful myelin regeneration (remyelination) in demyelinating diseases, such as multiple...
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Disrupted myelin lipid metabolism differentiates frontotemporal dementia caused by GRN and C9orf72 gene mutations
Heterozygous mutations in the GRN gene and hexanucleotide repeat expansions in C9orf72 are the two most common genetic causes of Frontotemporal...
