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Effects of Curcumin on Axon Growth and Myelin Sheath Formation in an In Vitro Model
Although the beneficial effects of curcumin, extracted from rhizomes of the ginger family genus Curcuma , on the repair and regeneration of nerves...
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Study on the Role and Mechanism of Exosomes Derived from Dental Pulp Stem Cells in Promoting Regeneration of Myelin Sheath in Rats with Sciatic Nerve Injury
The prognosis of peripheral nerve injury (PNI) is usually poor, and currently, there is no effective treatment for PNI. Studies have shown that...
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The transcription factor Stat-1 is essential for Schwann cell differentiation, myelination and myelin sheath regeneration
BackgroundMyelin sheath is a crucial accessory to the functional nerve-fiber unit, its disruption or loss can lead to axonal degeneration and...
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Synaptic input and Ca2+ activity in zebrafish oligodendrocyte precursor cells contribute to myelin sheath formation
In the nervous system, only one type of neuron–glial synapse is known to exist: that between neurons and oligodendrocyte precursor cells (OPCs), yet...
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Dynamics of mature myelin
Myelin, which is produced by oligodendrocytes, insulates axons to facilitate rapid and efficient action potential propagation in the central nervous...
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Myelin Imaging
Central myelin is an envelope composed of dozens of superimposed layers of the plasma membrane of oligodendrocytes around the neural axons. This...
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Myelin in Alzheimer’s disease: culprit or bystander?
Alzheimer’s disease (AD) is a neurodegenerative disorder with neuronal and synaptic losses due to the accumulation of toxic amyloid β (Αβ) peptide...
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Deletion of CD47 from Schwann cells and macrophages hastens myelin disruption/dismantling and scavenging in Schwann cells and augments myelin debris phagocytosis in macrophages
BackgroundMyelin that surrounds axons breaks in trauma and disease; e.g., peripheral nerve and spinal cord injuries (PNI and SCI) and multiple...
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Map** myelin in white matter with T1-weighted/T2-weighted maps: discrepancy with histology and other myelin MRI measures
The ratio of T1-weighted/T2-weighted magnetic resonance images (T1w/T2w MRI) has been successfully applied at the cortical level since 2011 and is...
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Environmental Deprivation Effects on Myelin Ultrastructure in Huntington Disease and Wildtype Mice
Environmental deprivation can have deleterious effects on adaptive myelination and oligodendroglia function. Early stage Huntington disease (HD) is...
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Quantifying myelin density in the feline auditory cortex
The cerebral cortex comprises many distinct regions that differ in structure, function, and patterns of connectivity. Current approaches to...
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Oligodendrocyte death initiates synchronous remyelination to restore cortical myelin patterns in mice
Myelin degeneration occurs in neurodegenerative diseases and aging. In these conditions, resident oligodendrocyte progenitor cells (OPCs)...
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Microglia regulation of central nervous system myelin health and regeneration
Microglia are resident macrophages of the central nervous system that have key functions in its development, homeostasis and response to damage and...
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The aminosteroid U73122 promotes oligodendrocytes generation and myelin formation
Oligodendrocytes (OLs) are glial cells that ensheath neuronal axons and form myelin in the central nervous system (CNS). OLs are differentiated from...
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miR-34a/TAN1/CREB Axis Engages in Alleviating Oligodendrocyte Trophic Factor-Induced Myelin Repair Function and Astrocyte-Dependent Neuroinflammation in the Early Stages of Alzheimer's Disease: The Anti-Neurodegenerative Effect of Treadmill Exercise
Reduced myelin stability observed in the early stages of Alzheimer's disease leads to spatial learning and memory impairment. Exercise has been shown...
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Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease
Axonal degeneration determines the clinical outcome of multiple sclerosis and is thought to result from exposure of denuded axons to immune-mediated...
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Teriflunomide as a therapeutic means for myelin repair
BackgroundPromotion of myelin repair in the context of demyelinating diseases such as multiple sclerosis (MS) still represents a clinical unmet need,...
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Trametinib, an anti-tumor drug, promotes oligodendrocytes generation and myelin formation
Oligodendrocytes (OLs) are differentiated from oligodendrocyte precursor cells (OPCs) in the central nervous system (CNS). Demyelination is a common...
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Individual neuronal subtypes control initial myelin sheath growth and stabilization
BackgroundIn the develo** central nervous system, pre-myelinating oligodendrocytes sample candidate nerve axons by extending and retracting process...
