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Limited sampling strategy and population pharmacokinetic model of mycophenolic acid in pediatric patients with systemic lupus erythematosus: application of a double gamma absorption model with SAEM algorithm
IntroductionMycophenolic acid (MPA), the active metabolite of mycophenolate mofetil (MMF), is widely used in the treatment of systemic lupus...
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Population pharmacokinetic and dose optimization of mycophenolic acid in children with anti-neutrophilic cytoplasmic antibody-associated nephritis
PurposeAnti-neutrophilic cytoplasmic antibody (ANCA)–associated vasculitis is a rare autoimmune disease. Mycophenolic acid (MPA) is widely used for...
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Meta-analysis of the associations of IMPDH and UGT1A9 polymorphisms with rejection in kidney transplant recipients taking mycophenolic acid
PurposeTo investigate the associations of IMPDH and UGT1A9 polymorphisms with rejection in kidney transplant recipients taking mycophenolic acid...
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A Systematic Review of Multiple Linear Regression-Based Limited Sampling Strategies for Mycophenolic Acid Area Under the Concentration–Time Curve Estimation
Background and ObjectiveOne approach of therapeutic drug monitoring in the case of mycophenolic acid (MPA) is a limited sampling strategy (LSS),...
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Pharmacokinetics of mycophenolic acid and external evaluation of two limited sampling strategies of drug exposure in patients with juvenile systematic lupus erythematosus
IntroductionMycophenolate mofetil (MMF), a pro-drug of mycophenolic acid (MPA), has become a major therapeutic option in juvenile systemic lupus...
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Mitomycin, 5-fluorouracil, leflunomide, and mycophenolic acid directly promote hepatitis B virus replication and expression in vitro
BackgroundReactivation of hepatitis B virus is a common complication that occurs in patients with hepatitis B virus (HBV) infection who have received...
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A Brief Insight into Peptide and Non-Peptide Drugs of Fungal Origin
Microorganisms are valuable resources for obtaining bioactive compounds, which have proven to be very useful in various domains, e.g., agriculture,...
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Premature senescence of placental decidua cells as a possible cause of miscarriage produced by mycophenolic acid
BackgroundSuccessful pregnancy is supported by a healthy maternal–fetal interface (i.e., the decidual tissues) which holds the conceptus and...
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Development of an HPLC method using relative molar sensitivity for the measurement of blood concentrations of nine pharmaceutical compounds
We developed a reliable high-performance liquid chromatographic analysis method using a relative molar sensitivity (RMS) technique that does not...
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Binding mechanism, conformation, and stability of diflunisal and mycophenolic acid with p300 HAT enzyme using molecular dynamics simulation and binding free energy analysis
Among all posttranslational modifications in eukaryotic cell, acetylation is an important one it is controlled by histone acetyltransferase (HAT)...
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Effects of Mycotoxins on Macrophages and Their Possible Clinical Implications
Fungi and their mycotoxins are ubiquitous, contaminating the air we breathe and the food we eat on a daily basis. Mycotoxins are considered a natural...
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Synthesis and evaluation of mycoph
e nolic acid derivatives as potential anti-Toxoplasma gondii agentsNineteen mycophenolic acid (MPA) derivatives were designed and synthesized, and their anti- Toxoplasma activity evaluated for the first time. Among...
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Transformation of the Amino Acid Pool in the Rat Brain under Conditions of Experimental Immunodeficiency
Abstract —The immune system, as one of the integrating general regulatory systems of the body, is in close relationship with the nervous and endocrine...
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Inosine monophosphate dehydrogenase type 2 polymorphism IMPDH2 3757T>C (rs11706052) and 12-month evolution of the graft function in renal transplant recipients on mycophenolate-based immunosuppression
Variant allele at the inosine monophosphate dehydrogenase type 2 polymorphism IMPDH2 3757T > C has been associated with increased enzyme activity and...
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Therapeutic Drug Monitoring and Toxicology of Immunosuppressant
Immunosuppressive medications have reached a great milestone in the treatment of numerous autoimmune diseases and the maintenance of immune response...
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Impact of SLCO1B3 polymorphisms on clinical outcomes in lung allograft recipients receiving mycophenolic acid
Single-nucleotide polymorphisms (SNPs) in genes involved in mycophenolic acid (MPA) metabolism have been shown to contribute to variable MPA...
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Antiproliferatives and Transplantation
Antiproliferative agents include Mycophenolic acid and Azathioprine (which is less commonly used unless in certain conditions). They were initially...
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Wnt/β-catenin signalling activates IMPDH2-mediated purine metabolism to facilitate oxaliplatin resistance by inhibiting caspase-dependent apoptosis in colorectal cancer
BackgroundOxaliplatin resistance usually leads to therapeutic failure and poor prognosis in colorectal cancer (CRC), while the underlying mechanisms...
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Limited sampling strategy to predict mycophenolic acid area under the curve in pediatric patients with nephrotic syndrome: a retrospective cohort study
PurposeLimited sampling strategy (LSS) is a precise and relatively convenient therapeutic drug monitoring method. We evaluated LSSs for mycophenolic...
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Comparative Evaluation of Median Versus Youden Index Dichotomization Methods: Exposure–Response Analysis of Mycophenolic Acid and Acyl-Glucuronide Metabolite
Background and ObjectivesDichotomization of pharmacokinetic exposure measures in exposure–response relationship studies provides results that are...
