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A sco** review of multigenerational impacts of grandparental exposures on mental health in grandchildren
Purpose of ReviewThe multigenerational effects of grandparental exposures on their grandchildren’s mental health and neurodevelopment are gaining...
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The miR-98-3p/JAG1/Notch1 axis mediates the multigenerational inheritance of osteopenia caused by maternal dexamethasone exposure in female rat offspring
As a synthetic glucocorticoid, dexamethasone is widely used to treat potential premature delivery and related diseases. Our previous studies have...
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Intergenerational transmission of brain structure and function in humans: a narrative review of designs, methods, and findings
Children often show cognitive and affective traits that are similar to their parents. Although this indicates a transmission of phenotypes from...
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Medication use before and during pregnancy in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
PurposeTo elucidate the status of medication use among pregnant women in Japan, by means of a multigenerational genome and birth cohort study: the...
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Whole-genome sequencing identifies functional noncoding variation in SEMA3C that cosegregates with dyslexia in a multigenerational family
Dyslexia is a common heritable developmental disorder involving impaired reading abilities. Its genetic underpinnings are thought to be complex and...
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Causal relationship between dietary salt intake and dementia risk: Mendelian randomization study
ObjectiveObservational research has indicated a potential link between dietary salt intake and susceptibility to dementia. However, it is important...
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A large pedigree study confirmed the CGG repeat expansion of RILPL1 Is associated with oculopharyngodistal myopathy
BackgroundOculopharyngodistal myopathy (OPDM) is an autosomal dominant adult-onset degenerative muscle disorder characterized by ptosis,...
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Evidence that the Ser192Tyr/Arg402Gln in cis Tyrosinase gene haplotype is a disease-causing allele in oculocutaneous albinism type 1B (OCA1B)
Oculocutaneous albinism type 1 (OCA1) is caused by pathogenic variants in the TYR (tyrosinase) gene which encodes the critical and rate-limiting...
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Looking Forward: Continuing Collaboration for Action
The second ASCL conference was held in February 2020, about 1 month after the first case of coronavirus disease 2019 (COVID-19) was documented in the...
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A novel protein truncating mutation in L2HGDH causes L-2-hydroxyglutaric aciduria in a consanguineous Pakistani family
BackgroundL-2-hydroxyglutaric aciduria (L2HGA) is a rare neurometabolic disorder that occurs due to accumulation of L-2-hydroxyglutaric acid in the...
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Linking Arsenic, DNA Methylation Biomarkers, and Transgenerational Neurotoxicity: Modeling in Zebrafish
Epigenetic mechanisms play a crucial role in maintaining nervous system functions, and dysregulation has been related to the development of...
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Natural history of NF1 c.2970_2972del p.(Met992del): confirmation of a low risk of complications in a longitudinal study
Individuals with the three base pair deletion NM_000267.3(NF1):c.2970_2972del p.(Met992del) have been recognised to present with a milder...
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Machine Learning for Predicting Organ Toxicity
Organ toxicity is a leading concern in safety assessment for regulatory agencies and pharmaceutical companies. Due to the huge amount of compounds...
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Childhood infections and autism spectrum disorders and/or intellectual disability: a register-based cohort study
ObjectiveTo explore the associations between childhood infections and subsequent diagnoses of autism spectrum disorder (ASD), intellectual disability...
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Perspectives on Healing and Recovery from Addiction with Ayahuasca-Based Therapy Among Members of an Indigenous Community in Canada
Indigenous populations in Canada and globally experience a disproportionate burden of social and health-related risks and harms due to...
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Mammalian Cells: Reliability as Model System in the Ecotoxicological Evaluation of Environmental Stressors
Disturbance in ecosystem balance is increasing drastically due to human interferences. Different kinds of toxins are continuously being released into...
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Linking Arsenic, DNA Methylation Biomarkers, and Transgenerational Neurotoxicity: Modeling in Zebrafish
Epigenetic mechanisms play a crucial role in maintaining nervous system functions, and dysregulation has been related to the development of...
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Deltamethrin and transfluthrin select for distinct transcriptomic responses in the malaria vector Anopheles gambiae
BackgroundThe widespread use of pyrethroid insecticides in Africa has led to the development of strong resistance in Anopheles mosquitoes....
