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Prognostication of Functional Outcomes of Schizophrenia Using a Multigene Panel
Objectives. To compare groups of schizophrenia patients with different levels of functional outcomes and different frequencies of risk variants at...
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Multigene profiles to guide the use of neoadjuvant chemotherapy for breast cancer: a Copenhagen Breast Cancer Genomics Study
Estrogen receptor (ER) and human epidermal growth factor 2 (HER2) expression guide the use of neoadjuvant chemotherapy (NACT) in patients with early...
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Knowledge and psychosocial impact of genetic counseling and multigene panel testing among individuals with ovarian cancer
In a sample of individuals with ovarian cancer, we aimed to (a) identify factors associated with the psychosocial impact of genetic counseling and...
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Multigene Panel Testing for Hereditary Cancer and Genetic Counseling
As sequencing technology and information of the genomic causes for cancer development expand, multi-gene panel testing for hereditary cancer is...
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Uptake and acceptability of a mainstreaming model of hereditary cancer multigene panel testing among patients with ovarian, pancreatic, and prostate cancer
PurposeTo address demands for timely germline information to guide treatments, we evaluated experiences of patients with ovarian, pancreatic, and...
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PROCURE European consensus on breast cancer multigene signatures in early breast cancer management
Breast cancer multigene signatures (BCMS) have changed how patients with early-stage breast cancer (eBC) are managed, as they provide prognostic...
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Germline whole genome sequencing in adults with multiple primary tumors
Multiple primary tumors (MPTs) are a harbinger of hereditary cancer syndromes. Affected individuals often fit genetic testing criteria for a number...
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Clinical and psychological outcomes of receiving a variant of uncertain significance from multigene panel testing or genomic sequencing: a systematic review and meta-analysis
This study systematically reviewed and synthesized the literature on psychological and clinical outcomes of receiving a variant of uncertain...
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BRCA genes as candidates for colorectal cancer genetic testing panel: systematic review and meta-analysis
BackgroundBreast cancer susceptibility gene (BRCA) mutation carriers are at an increased risk for breast, ovarian, prostate and pancreatic cancers....
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Evaluating the utility of multi-gene, multi-disease population-based panel testing accounting for uncertainty in penetrance estimates
Panel germline testing allows for the efficient detection of deleterious variants for multiple conditions, but the benefits and harms of identifying...
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Collaborative Group of the Americas on Inherited Gastrointestinal Cancer Position statement on multigene panel testing for patients with colorectal cancer and/or polyposis
Multigene panel tests for hereditary cancer syndromes are increasingly utilized in the care of colorectal cancer (CRC) and polyposis patients....
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Prevalence of mutations in a diverse cohort of 3162 women tested via the same multigene cancer panel in a managed care health plan
Advances in gene sequencing of mutations related to hereditary cancers have enabled expansion of this testing to patients cared for in community...
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BRCA1/2 potential founder variants in the Jordanian population: an opportunity for a customized screening panel
A founder variant is a genetic alteration, that is inherited from a common ancestor together with a surrounding chromosomal segment, and is observed...
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‘We don’t know for sure’: discussion of uncertainty concerning multigene panel testing during initial cancer genetic consultations
Pre-test counseling about multigene panel testing involves many uncertainties. Ideally, counselees are informed about uncertainties in a way that...
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Recommendations from the European Commission Initiative on Breast Cancer for multigene testing to guide the use of adjuvant chemotherapy in patients with early breast cancer, hormone receptor positive, HER-2 negative
BackgroundPredicting the risk of recurrence and response to chemotherapy in women with early breast cancer is crucial to optimise adjuvant treatment....
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Exploration of intermediate-sized INDELs by next-generation multigene panel testing in Han Chinese patients with breast cancer
Multigene panel testing via next-generation sequencing focuses on the detection of small-sized mutations, such as single nucleotide variants and...
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BARD1 deletion in a patient with suspected hereditary colorectal cancer
Deleterious germline variants in the BRCA1-associated ring domain ( BARD1 ) gene moderately elevate breast cancer risk; however, their potential...
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Development and validation of a circulating microRNA panel for the early detection of breast cancer
BackgroundMammography is widely used for breast cancer screening but suffers from a high false-positive rate. Here, we perform the largest...
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Occurrence of variants of unknown clinical significance in genetic testing for hereditary breast and ovarian cancer syndrome and Lynch syndrome: a literature review and analytical observational retrospective cohort study
Background and purposeOver the last decade, the implementation of multigene panels for hereditary tumor syndrome has increased at our institution...
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MassARRAY multigene screening combined with LDL-C and sdLDL-C detection for more favorable outcomes in type 2 diabetes mellitus therapy
BackgroundTo determine the clinical value of multigene polymorphisms, LDL-C and sdLDL-C on T2DM therapy.
MethodsIn total, 352 T2DM patients before...
