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Evaluating in vivo effectiveness of sotrovimab for the treatment of Omicron subvariant BA.2 versus BA.1: a multicentre, retrospective cohort study
BackgroundIn vitro data suggested reduced neutralizing capacity of sotrovimab, a monoclonal antibody, against Omicron BA.2 subvariant. However,...
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Parkinson's disease peripheral immune biomarker profile: a multicentre, cross-sectional and longitudinal study
BackgroundInflammations play crucial role in the pathogenesis of Parkinson’s disease (PD), however, their possible value in the diagnosis or tracking...
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Attention-based deep learning for breast lesions classification on contrast enhanced spectral mammography: a multicentre study
BackgroundThis study aims to develop an attention-based deep learning model for distinguishing benign from malignant breast lesions on CESM.
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A multicentre evaluation and expert recommendations of use of the newly developed BioFire Joint Infection polymerase chain reaction panel
Septic arthritis is a serious condition with significant morbidity and mortality, routinely diagnosed using culture. The FDA has recently approved...
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Effects of neoadjuvant radiochemotherapy for anorectal function in locally advanced rectal cancer patients: a study protocol for a prospective, observational, controlled, multicentre study
BackgroundNeoadjuvant chemoradiotherapy (NCRT) and total mesorectal excision are standard treatment regimen for patients with locally advanced rectal...
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Comparing biweekly single-dose actinomycin D with multiday methotrexate therapy for low-risk gestational trophoblastic neoplasia (FIGO Score 0–4): study protocol for a prospective, multicentre, randomized trial
BackgroundSingle-agent chemotherapy using methotrexate or actinomycin D is the first-line treatment for patients with low-risk gestational...
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Anus preservation in low rectal adenocarcinoma based on MMR/MSI status (APRAM): a study protocol for a randomised, controlled, open-label, multicentre phase III trial
BackgroundAnus preservation has been a challenge in the treatment of patients with low rectal adenocarcinoma (within 5 cm from the anal verge)...
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Fatigue and symptom-based clusters in post COVID-19 patients: a multicentre, prospective, observational cohort study
BackgroundIn the Netherlands, the prevalence of post COVID-19 condition is estimated at 12.7% at 90–150 days after SARS-CoV-2 infection. This study...
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A multicentre study on the incidence of respiratory viruses in children with community-acquired pneumonia requiring hospitalization in the setting of the zero-COVID policy in China
BackgroundStringent nonpharmaceutical interventions (NPIs) have been implemented worldwide to combat the COVID-19 pandemic, and the circulation and...
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Prediction of residual disease using circulating DNA detection after potentiated radiotherapy for locally advanced head and neck cancer (NeckTAR): a study protocol for a prospective, multicentre trial
BackgroundSensitive and reproducible detection of residual disease after treatment is a major challenge for patients with locally advanced head and...
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Dual [68Ga]DOTATATE and [18F]FDG PET/CT in patients with metastatic gastroenteropancreatic neuroendocrine neoplasms: a multicentre validation of the NETPET score
BackgroundGastroenteropancreatic neuroendocrine neoplasms (GEPNENs) are heterogeneous in clinical course, biology, and outcomes. The NETPET score...
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Findings from a Malaysian multicentre study on oropharyngeal squamous cell carcinoma
BackgroundIn addition to the conventional aetiologic agents of oropharyngeal squamous cell carcinoma (OPSCC) such as tobacco usage, alcohol...
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Validation of a new risk stratification system-based management for methicillin-resistant Staphylococcus aureus bacteraemia: analysis of a multicentre prospective study
PurposeDistinguishing between complicated and uncomplicated Staphylococcus aureus bacteraemia (SAB) is therapeutically essential. However, this...
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Patterns of staging, treatment, and mortality in gastric, colorectal, and lung cancer among older adults with and without preexisting dementia: a Japanese multicentre cohort study
BackgroundLittle is known about dementia’s impact on patterns of diagnosis, treatment, and outcomes in cancer patients. This study aimed to elucidate...
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Bacterial profile of surgical site infection and antimicrobial resistance patterns in Ethiopia: a multicentre prospective cross-sectional study
BackgroundGlobally, surgical site infections (SSI) are the most commonly reported healthcare-associated infections.
MethodsA multicentre study was...
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Biopsy for advanced hepatocellular carcinoma: results of a multicentre UK audit
BackgroundAdvanced hepatocellular carcinoma (HCC) is commonly diagnosed using non-invasive radiological criteria (NIRC) defined by the European...
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Nanopore sequencing for smear-negative pulmonary tuberculosis—a multicentre prospective study in China
PurposeIn this prospective study, the diagnosis accuracy of nanopore sequencing-based Mycobacterium tuberculosis (MTB) detection was determined...
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Evaluating atezolizumab in patients with urinary tract squamous cell carcinoma (AURORA): study protocol for a single arm, open-label, multicentre, phase II clinical trial
BackgroundBladder and urinary tract cancers account for approximately 21,000 new diagnoses and 5,000 deaths annually in the UK. Approximately 90% are...
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Transfer, Collection and Organisation of Electrophysiological and Imaging Data for Multicentre Studies
Multicentre studies are of utmost importance to confirm hypotheses. The lack of established standards and the ensuing complexity of their data...
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SARS-CoV-2 antibodies in inflammatory neurological conditions: a multicentre retrospective comparative study
It is well established that neurological and non-neurological autoimmune disorders can be triggered by viral infections. It remains unclear whether...
