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Single-nucleus multi-omic profiling of human placental syncytiotrophoblasts identifies cellular trajectories during pregnancy
The human placenta has a vital role in ensuring a successful pregnancy. Despite the growing body of knowledge about its cellular compositions and...
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Multi-trajectories of lipid indices with incident cardiovascular disease, heart failure, and all-cause mortality: 23 years follow-up of two US cohort studies
BackgroundUnderstanding the distinct patterns (trajectories) of variation in blood lipid levels before diagnosing cardiovascular disease (CVD) might...
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Patterns of change in obesity indices and other cardiometabolic risk factors before the diagnosis of type 2 diabetes: two decades follow-up of the Tehran lipid and glucose study
BackgroundIdentifying patterns of variation in obesity indices and other cardiometabolic risk factors before the diagnosis of type 2 diabetes could...
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A multi-site study on sex differences in cortical thickness in non-demented Parkinson’s disease
Clinical, cognitive, and atrophy characteristics depending on sex have been previously reported in Parkinson’s disease (PD). However, though sex...
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Tracking reactive astrogliosis in autosomal dominant and sporadic Alzheimer’s disease with multi-modal PET and plasma GFAP
BackgroundPlasma assays for the detection of Alzheimer’s disease neuropathological changes are receiving ever increasing interest. The concentration...
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Brain fiber structure estimation based on principal component analysis and RINLM filter
Diffusion magnetic resonance imaging is a technique for non-invasive detection of microstructure in the white matter of the human brain, which is...
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Anopheles stephensi in Africa requires a more integrated response
There are increasing reports of the Asian malaria mosquito, Anopheles stephensi invading and spreading in Eastern Africa. We discuss the importance...
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Multiscale heterogeneity in gastric adenocarcinoma evolution is an obstacle to precision medicine
BackgroundCancer is a somatic evolutionary disease and adenocarcinomas of the stomach and gastroesophageal junction (GC) may serve as a...
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Prognostic association of medication trajectories with 3-year mortality in heart failure and preserved ejection fraction: findings from the EPICAL2 cohort study
PurposeThe aims of this study were to describe combinations of beta-blockers (BB), renin-angiotensin system (RAS) blockers, and mineralocorticoid...
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Distinct evolutionary trajectories of MHC class I and class II genes in Old World finches and buntings
Major histocompatibility complex (MHC) genes code for key proteins of the adaptive immune system, which present antigens from intra-cellular (MHC...
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Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis
BackgroundTraditionally, the transcriptomic and proteomic characterisation of CD4 + T cells at the single-cell level has been performed by two...
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Linking gastrointestinal microbiota and metabolome dynamics to clinical outcomes in paediatric haematopoietic stem cell transplantation
BackgroundHaematopoietic stem cell transplantation is a curative procedure for a variety of conditions. Despite major advances, a plethora of adverse...
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Noninvasive Tracking of Every Individual in Unmarked Mouse Groups Using Multi-Camera Fusion and Deep Learning
Accurate and efficient methods for identifying and tracking each animal in a group are needed to study complex behaviors and social interactions....
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The generative grammar of the brain: a critique of internally generated representations
The past decade of progress in neurobiology has uncovered important organizational principles for network preconfiguration and neuronal selection...
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Multi-Capsule Endoscopy: An initial study on modeling and phantom experimentation of a magnetic capsule train
PurposeCapsule endoscopy offers increased patient comfort and improved visibility of the entire gastrointestinal (GI) tract. Besides imaging,...
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Optimized glycemic control of type 2 diabetes with reinforcement learning: a proof-of-concept trial
The personalized titration and optimization of insulin regimens for treatment of type 2 diabetes (T2D) are resource-demanding healthcare tasks. Here...
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Optimum trajectory learning in musculoskeletal systems with model predictive control and deep reinforcement learning
From the computational point of view, musculoskeletal control is the problem of controlling high degrees of freedom and dynamic multi-body system...
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Sport-Specific Recovery Trajectories for NCAA Collegiate Athletes Following Concussion
The recovery trajectories of collegiate athletes with sport-related concussion (SRC) are well characterized in contact/collision sports but are less...
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Gene regulatory network inference in the era of single-cell multi-omics
The interplay between chromatin, transcription factors and genes generates complex regulatory circuits that can be represented as gene regulatory...
