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Mucin-microbiome signatures shape the tumor microenvironment in gastric cancer
Background and aimsWe aimed to identify mucin-microbiome signatures sha** the tumor microenvironment in gastric adenocarcinomas and clinical...
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Breaking the Mucin Barrier: A New Affinity Chromatography-Mass Spectrometry Approach to Unveil Potential Cell Markers and Pathways Altered in Pseudomyxoma Peritonei
BackgroundPseudomyxoma peritonei (PMP) is a rare peritoneal mucinous carcinomatosis with largely unknown underlying molecular mechanisms....
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Deciphering cellular and molecular mechanism of MUC13 mucin involved in cancer cell plasticity and drug resistance
There has been a surge of interest in recent years in understanding the intricate mechanisms underlying cancer progression and treatment resistance....
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Talniflumate abrogates mucin immune suppressive barrier improving efficacy of gemcitabine and nab-paclitaxel treatment in pancreatic cancer
BackgroundPancreatic ductal adenocarcinoma (PDAC) is a lethal disease. This is due to its aggressive course, late diagnosis and its intrinsic drugs...
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Four functional profiles for fibre and mucin metabolism in the human gut microbiome
BackgroundWith the emergence of metagenomic data, multiple links between the gut microbiome and the host health have been shown. Deciphering these...
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Compendium of 5810 genomes of sheep and goat gut microbiomes provides new insights into the glycan and mucin utilization
BackgroundRuminant gut microbiota are critical in ecological adaptation, evolution, and nutrition utilization because it regulates energy metabolism,...
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Mucin O-glycan-microbiota axis orchestrates gut homeostasis in a diarrheal pig model
BackgroundPost-weaning diarrhea in piglets reduces growth performance and increases mortality, thereby causing serious economic losses. The...
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Stable expression of mucin glycoproteins GP40 and GP15 of Cryptosporidium parvum in Toxoplasma gondii
BackgroundCryptosporidium spp. are common protozoa causing diarrhea in humans and animals. There are currently only one FDA-approved drug and no...
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An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1
BackgroundLung cancer cells overexpress mucin 1 (MUC1) and active subunit MUC1-CT. Although a peptide blocks MUC1 signalling, metabolites targeting...
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Comparison of mucin-1 in human breast cancer and canine mammary gland tumor: a review study
Mucin-1 (MUC-1) is a transmembrane glycoprotein, which bears many similarities between dogs and humans. Since the existence of animal models is...
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Short chain fatty acids-producing and mucin-degrading intestinal bacteria predict the progression of early Parkinson’s disease
To elucidate the relevance of gut dysbiosis in Parkinson’s disease (PD) in disease progression, we made random forest models to predict the...
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Muc2 mucin o-glycosylation interacts with enteropathogenic Escherichia coli to influence the development of ulcerative colitis based on the NF-kB signaling pathway
BackgroundUlcerative colitis (UC) is a chronic inflammatory disease of the intestine characterized by a compromised intestinal epithelial barrier....
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A survival comparison of gastric mucin-producing adenocarcinoma to conventional adenocarcinoma: a SEER database analysis
BackgroundCompared to conventional adenocarcinoma (CA), mucin-producing adenocarcinoma (MPA) is an uncommon histological subtype and is usually...
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The mucin-like, secretory type-I transmembrane glycoprotein GP900 in the apicomplexan Cryptosporidium parvum is cleaved in the secretory pathway and likely plays a lubrication role
BackgroundCryptosporidium parvum is a zoonotic parasite and member of the phylum Apicomplexa with unique secretory organelles, including a rhoptry,...
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The pH Dependence of Niclosamide Solubility, Dissolution, and Morphology: Motivation for Potentially Universal Mucin-Penetrating Nasal and Throat Sprays for COVID19, its Variants and other Viral Infections
MotivationWith the coronavirus pandemic still raging, prophylactic-nasal and early-treatment throat-sprays could help prevent infection and reduce...
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Pancreatic Cancer: Pursuit of Mucins from Progression to Prognosis
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy characterized by a late diagnosis, poor survival, and limited treatment options....
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Immunohistochemical detection of MUC5AC and MUC5B mucins in ferrets
ObjectiveCystic fibrosis (CF) is a genetic condition that causes abnormal mucus secretions in affected organs. MUC5AC and MUC5B are gel-forming...
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The potential role of ocular and otolaryngological mucus proteins in myalgic encephalomyelitis/chronic fatigue syndrome
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating illness associated with a constellation of other symptoms. While the...
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Pancreatic Cancer: Pursuit of Mucins from Progression to Prognosis
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy characterized by a late diagnosis, poor survival, and limited treatment options....