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Preparatory activity and the expansive null-space
The study of the cortical control of movement experienced a conceptual shift over recent decades, as the basic currency of understanding shifted from...
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Increased presence of nuclear DNAJA3 and upregulation of cytosolic STAT1 and of nucleic acid sensors trigger innate immunity in the ClpP-null mouse
Mitochondrial dysfunction may activate innate immunity, e.g. upon abnormal handling of mitochondrial DNA in TFAM mutants or in altered mitophagy....
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Identification of senescent, TREM2-expressing microglia in aging and Alzheimer’s disease model mouse brain
Alzheimer’s disease (AD) and dementia in general are age-related diseases with multiple contributing factors, including brain inflammation....
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Tottering Mouse
The tottering mouse (tg/tg) results from a mutation in the gene that encodes for the Cav2.1 (P/Q-type) Ca2+ channel and is a model for the Cav2.1...
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A novel mouse model for familial hypocalciuric hypercalcemia (FHH1) reveals PTH-dependent and independent CaSR defects
The Calcium-sensing receptor (CaSR) senses extracellular calcium, regulates parathyroid hormone (PTH) secretion, and has additional functions in...
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Rolling Nagoya Mouse
The natural mutant mouse rolling Nagoya has an uncoordinated gait and frequently displays sideways body rolls. The mutation underlying this autosomal...
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Abnormal Innervation, Demyelination, and Degeneration of Spiral Ganglion Neurons as Well as Disruption of Heminodes are Involved in the Onset of Deafness in Cx26 Null Mice
GJB2 gene mutations are the most common causes of autosomal recessive non-syndromic hereditary deafness. For individuals suffering from severe to...
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An overview of mouse models of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) has become a severe burden on global health due to its high morbidity and mortality rates. However, effective...
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Personalized Immuno-Oncology with Immunodeficiency Mouse Models
In the past decades, cancer therapies are evolved from a non-specific approach to a precise and accurate therapy. Precision (or personalized) cancer...
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Updates on mouse models of Alzheimer’s disease
Alzheimer’s disease (AD) is the most common neurodegenerative disease in the United States (US). Animal models, specifically mouse models have been...
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Cystine/glutamate antiporter xCT deficiency reduces metastasis without impairing immune system function in breast cancer mouse models
BackgroundThe upregulation of antioxidant mechanisms is a common occurrence in cancer cells, as they strive to maintain balanced redox state and...
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Map** spatially resolved transcriptomes in human and mouse pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor prognosis and limited treatment options. Efforts to identify effective...
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Mucociliary Transit Assessment Using Automatic Tracking in Phase Contrast X-Ray Images of Live Mouse Nasal Airways
PurposeThe rate of mucociliary transit (MCT) is an indicator of the hydration and health of the airways for cystic fibrosis (CF). To determine the...
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Behavior-relevant top-down cross-modal predictions in mouse neocortex
Animals adapt to a constantly changing world by predicting their environment and the consequences of their actions. The predictive coding hypothesis...
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The developmental timing of spinal touch processing alterations predicts behavioral changes in genetic mouse models of autism spectrum disorders
Altered somatosensory reactivity is frequently observed among individuals with autism spectrum disorders (ASDs). Here, we report that although...
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Mendelian gene identification through mouse embryo viability screening
BackgroundThe diagnostic rate of Mendelian disorders in sequencing studies continues to increase, along with the pace of novel disease gene...
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Adenosine A2A receptor null chondrocyte transcriptome resembles that of human osteoarthritic chondrocytes
Adenosine signaling plays a critical role in the maintenance of articular cartilage and may serve as a novel therapeutic for osteoarthritis (OA), a...
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Null Function of Npr1 Disturbs Immune Response in Colonic Inflammation During Early Postnatal Stage
Natriuretic peptide receptor 1 (NPR1) is conventionally known as a regulator of vascular homeostasis. Here, we generated an Npr1 knockout mouse model...
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In vivo affinity maturation of mouse B cells reprogrammed to express human antibodies
Mice adoptively transferred with mouse B cells edited via CRISPR to express human antibody variable chains could help evaluate candidate vaccines and...
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Successful use of HTF as a basal fertilization medium during SEcuRe mouse in vitro fertilization
ObjectiveThe ever-increasing number of genetically engineered mouse models highlights the need for efficient archiving and distribution of these...
