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1. Emerging Trends in Monoclonal Antibody Therapies Targeting Cancer

   Monoclonal antibody-based immunotherapy is a crucial component of cancer therapy. Advances in genetic engineering allowed for modifications that have...

   Salwan Al Hani, Sarah Provencher, ... Kyeorda Kemp in Handbook of Cancer and Immunology

   Living reference work entry 2023
   

2. Anti-PEc: Development of a novel monoclonal antibody against prostate cancer

   Background

   The Ec peptide (PEc) that defines the IGF-1Ec isoform, is associated with prostate cancer progression by inducing proliferation,...

   Athanasios Armakolas, Nektarios Alevizopoulos, ... Michael Koutsilieris in British Journal of Cancer

   Article 20 June 2024
   

3. Monoclonal Antibody Targeting CGRP Relieves Cisplatin-Induced Neuropathic Pain by Attenuating Neuroinflammation

   Chemotherapy-induced neuropathic pain (CIPN) is a common side effect of antitumor chemotherapeutic agents. It describes a pathological state of pain...

   Shun **e, Zhenfang Gao, ... Taiqian Gong in Neurotoxicity Research

   Article 09 January 2024
   

4. Evolution of Antidrug Antibody Assays During the Development of Anti-Tissue Factor Pathway Inhibitor Monoclonal Antibody Marstacimab

   Tissue factor pathway inhibitor (TFPI) is an endogenous inhibitor of the extrinsic coagulation pathway. In patients with hemophilia A or B,...

   Jean Donley, Darshana Jani, ... Steven Arkin in The AAPS Journal

   Article Open access 23 August 2023
   

5. Development of a highly effective combination monoclonal antibody therapy against Herpes simplex virus

   Background

   Infections with Herpes simplex virus (HSV)-1 or -2 usually present as mild chronic recurrent disease, however in rare cases can result in...

   Narges Seyfizadeh, David Kalbermatter, ... Michaela Arndt in Journal of Biomedical Science

   Article Open access 28 May 2024
   

6. An Overview of Mouse Monoclonal Antibody Production

   Antibodies are an important tool in the field of diagnostics and therapeutics owing to their affinity to bind with specific antigen. These can be of...

   Kaushal Kishor Rajak, Kiran, ... R. P. Singh in Protocols for the Diagnosis of Pig Viral Diseases

   Protocol 2022
   

7. Pfs230 Domain 7 is targeted by a potent malaria transmission-blocking monoclonal antibody

   Malaria transmission-blocking vaccines (TBVs) aim to induce antibodies that block Plasmodium parasite development in the mosquito midgut, thus...

   Maartje R. Inklaar, Roos M. de Jong, ... Matthijs M. Jore in npj Vaccines

   Article Open access 12 December 2023
   

8. Vaccination with a replication-defective cytomegalovirus vaccine elicits a glycoprotein B-specific monoclonal antibody repertoire distinct from natural infection

   Human Cytomegalovirus (HCMV) is the leading infectious congenital infection globally and the most common viral infection in transplant recipients,...

   Sarah M. Valencia, Eric Rochat, ... Sallie R. Permar in npj Vaccines

   Article Open access 10 October 2023
   

9. An anti-LpqH human monoclonal antibody from an asymptomatic individual mediates protection against Mycobacterium tuberculosis

   Tuberculosis (TB) is an airborne disease caused by Mycobacterium tuberculosis (Mtb). Whilst a functional role for humoral immunity in Mtb protection...

   Shivankari Krishnananthasivam, Hao Li, ... Paul A. MacAry in npj Vaccines

   Article Open access 25 August 2023
   

10. Lutetium-177 Labelled Anti-PSMA Monoclonal Antibody (Lu-TLX591) Therapy for Metastatic Prostate Cancer: Treatment Toxicity and Outcomes

    Introduction

    Whilst prostate cancer is the fourth most common cancer globally, effective therapies for patients with advanced disease are lacking. In...

    Hanh Nguyen, Kathryn Hird, ... Nat P. Lenzo in Molecular Diagnosis & Therapy

    Article Open access 06 March 2024
    

11. Therapeutic Monoclonal Antibody Therapies in Chronic Autoimmune Demyelinating Neuropathies

    Autoimmune diseases of the peripheral nervous system have so far been treated mainly with exogenous high-dose intravenous immunoglobulins (IVIg),...

    Chiara Briani, Andrea Visentin in Neurotherapeutics

    Article Open access 28 March 2022
    

12. IC100, a humanized therapeutic monoclonal anti-ASC antibody alleviates oxygen-induced retinopathy in mice

    Background

    Retinopathy of prematurity (ROP), which often presents with bronchopulmonary dysplasia (BPD), is among the most common morbidities...

    Huijun Yuan, Shaoyi Chen, ... Shu Wu in Angiogenesis

    Article Open access 06 May 2024
    

13. Comparison of monoclonal antibody disposition predictions using different physiologically based pharmacokinetic modelling platforms

    Physiologically based pharmacokinetic (PBPK) models can be used to leverage physiological and in vitro data to predict monoclonal antibody (mAb)...

    Pieter-Jan De Sutter, Elke Gasthuys, An Vermeulen in Journal of Pharmacokinetics and Pharmacodynamics

    Article 12 November 2023
    

14. Monoclonal Antibodies in Solid Organ Transplantation

    In an attempt to target solid organ transplant immunosuppression, monoclonal antibodies directed against key steps in specific immunologic pathways...

    Nicole A. Pilch, Holly B. Meadows, Rita R. Alloway in Pharmaceutical Biotechnology

    Chapter 2024
    

15. The Osmolality and Hemolysis of High-Concentration Monoclonal Antibody Formulations

    Purposes

    Highly concentrated monoclonal antibody (mAb) formulations for subcutaneous administration are becoming increasingly preferred within the...

    Meng-Juan Pang, Meng-Wen Wang, ... Wei-Jie Fang in Pharmaceutical Research

    Article 03 January 2024
    

16. Production of Neutralizing Antibody

    Techniques employing monoclonal antibodies (mAbs) are widely used in the initial development phase of biologics. The usefulness of mAbs in basic RA...

    Erika Takemasa, Shuang Liu in Rheumatoid Arthritis

    Protocol 2024
    

17. Gantenerumab: an anti-amyloid monoclonal antibody with potential disease-modifying effects in early Alzheimer’s disease

    Background

    This review describes the research and development process of gantenerumab, a fully human anti-amyloid monoclonal antibody in development...

    Randall J. Bateman, Jeffrey Cummings, ... Rachelle S. Doody in Alzheimer's Research & Therapy

    Article Open access 29 November 2022
    

18. Therapeutic effect of a MUC1-specific monoclonal antibody-drug conjugates against pancreatic cancer model

    Background

    Pancreatic cancer is one of the most aggressive malignancies without effective targeted therapies. MUC1 has emerged as a potential common...

    Guang Wu, Lan Li, ... Haihua Gu in Cancer Cell International

    Article Open access 27 December 2022
    

19. Prolonged viral pneumonia and high mortality in COVID-19 patients on anti-CD20 monoclonal antibody therapy

    Purpose

    In clinical practice, we observed an apparent overrepresentation of COVID-19 patients on anti-CD20 monoclonal antibody therapy. The aim of...

    Eeva Feuth, Valtteri Nieminen, ... Thijs Feuth in European Journal of Clinical Microbiology & Infectious Diseases

    Article Open access 15 February 2024
    

20. Long-term passaging of pseudo-typed SARS-CoV-2 reveals the breadth of monoclonal and bispecific antibody cocktails

    The continuous emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants poses challenges to the effectiveness of...

    Hang Ma, Hui-fang Zong, ... Jian-wei Zhu in Acta Pharmacologica Sinica

    Article 27 January 2023