Search
Search Results
-
Monoclonal Antibodies in Solid Organ Transplantation
In an attempt to target solid organ transplant immunosuppression, monoclonal antibodies directed against key steps in specific immunologic pathways...
-
A Short Update on the Use of Monoclonal Antibodies in COVID-19
Monoclonal antibodies in the prophylaxis and treatment of COVID-19 have been crucial in reducing severe infections when vaccines were unavailable....
-
Dry Powder Formulation of Monoclonal Antibodies for Pulmonary Delivery
Interest in monoclonal antibody therapy for lung indications has grown substantially in the last decade. Local delivery of monoclonal antibody...
-
Monoclonal Antibodies: From Structure to Therapeutic Application
The exciting field of therapeutic monoclonal antibodies (mAbs) had its origins when Köhler and Milstein presented their murine hybridoma technology...
-
Anti-Calcitonin Gene-Related Peptide Monoclonal Antibodies in Migraine: Focus on Drug Interactions
Calcitonin gene-related peptide neurotransmission was the target for recent development of monoclonal antibodies that effectively prevent attacks of...
-
Anti-calcitonin Gene-Related Peptide Monoclonal Antibodies in Migraine: Focus on Clinical Pharmacokinetics
The calcitonin gene-related peptide transmission was the target for recent development of drugs that effectively prevent attacks of both episodic and...
-
Preparation of monoclonal antibodies against Epstein-Barr virus glycoprotein 350
Epstein-Barr virus (EBV) is the first identified human oncogenic herpesvirus infecting over 90% of the adults worldwide. However, the safe and...
-
Benchmark Glycan Profile of Therapeutic Monoclonal Antibodies Produced by Mammalian Cell Expression Systems
PurposeThis study aims to establish a benchmark glycan profile for commercial therapeutic monoclonal antibodies (mAbs) approved by the US Food and...
-
Anti-Amyloid Monoclonal Antibodies for the Treatment of Alzheimer’s Disease
Two monoclonal antibodies (mAbs), aducanumab and lecanemab, have received accelerated approval from the US FDA for initiation of treatment in early...
-
Therapeutic Human Monoclonal Antibodies
Since the discovery of obtaining mouse monoclonal antibodies (MAbs) in 1975 by somatic cell hybridization, there have been rapid developments to use...
-
Development of monoclonal antibodies against oropouche virus and its applicability to immunohistochemical diagnosis
Orthobunyavirus oropouche ense virus (OROV), the causative agent of Oropouche fever, is widely dispersed in Brazil and South America, causing...
-
Monoclonal Antibodies in Nanosystems as a Strategy for Cancer Treatment
Monoclonal antibodies (mAbs) are valuable therapeutic tools for targeted therapies to attack tumor cells but preserve healthy tissues, therefore...
-
Note on importance of correct stoichiometric assumptions for modeling of monoclonal antibodies
Pharmacokinetic modeling of monoclonal antibodies (mAbs) with non-linear binding is based on equations of the target-mediated drug disposition (Mager...
-
Omicron variant evolution on vaccines and monoclonal antibodies
The severe acute respiratory syndrome coronavirus (SARS-CoV)-2 responsible for the global COVID-19 pandemic has caused almost 760 million confirmed...
-
Reducing Immunogenicity by Design: Approaches to Minimize Immunogenicity of Monoclonal Antibodies
Monoclonal antibodies (mAbs) have transformed therapeutic strategies for various diseases. Their high specificity to target antigens makes them ideal...
-
Exploring the therapeutic potential of monoclonal antibodies targeting TSLP and IgE in asthma management
BackgroundIn recent years, there has been a growing interest in the utilization of biologic therapies for the management of asthma. Both TSLP and IgE...
-
Anti-TRAP/SSP2 monoclonal antibodies can inhibit sporozoite infection and may enhance protection of anti-CSP monoclonal antibodies
Vaccine-induced sterilizing protection from infection by Plasmodium parasites, the pathogens that cause malaria, will be essential in the fight...
-
Development of Immunoliposomes Using Monoclonal Antibodies Targeting Cancer Stem Cells
A cell surface glycoprotein of hyaluronic acid (HA) receptor is known as CD44, which is often overexpressed in most types of tumors. CD44 has...
-
Monoclonal anti-CGRP antibodies in post-menopausal women: a real-life study
IntroductionMigraine usually ameliorates after menopause. However, 10–29% of women still experience migraine attacks after menopause, especially if...
-
COVID-19 Therapeutics: Use, Mechanism of Action, and Toxicity (Vaccines, Monoclonal Antibodies, and Immunotherapeutics)
SARS-CoV-2 emerged in December 2019 and led to the COVID-19 pandemic. Efforts to develop therapeutics have led to innovations such as mRNA vaccines...