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Incorporating clinicopathological and molecular risk prediction tools to improve outcomes in early HR+/HER2– breast cancer
Stratification of recurrence risk is a cornerstone of early breast cancer diagnosis that informs a patient’s optimal treatment pathway. Several tools...
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Shared molecular genetic factors influence subcortical brain morphometry and Parkinson’s disease risk
Parkinson’s disease (PD) is a late-onset and genetically complex neurodegenerative disorder. Here we sought to identify genes and molecular pathways...
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Association of reproductive risk factors and breast cancer molecular subtypes: a systematic review and meta-analysis
BackgroundAssociations between reproductive factors and breast cancer (BC) risk vary by molecular subtype (i.e., luminal A, luminal B, HER2, and...
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Transcription factors-related molecular subtypes and risk prognostic model: exploring the immunogenicity landscape and potential drug targets in hepatocellular carcinoma
BackgroundHepatocellular carcinoma (HCC) is the most prevalent form of liver cancer, with a high mortality rate and poor prognosis. Mutated or...
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Unveiling the molecular landscape of cognitive aging: insights from polygenic risk scores, DNA methylation, and gene expression
BackgroundAging represents a significant risk factor for the occurrence of cerebral small vessel disease, associated with white matter (WM) lesions,...
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Molecular detection and assessment of risk factors for Theileria lestoquardi in sheep from Balochistan, Pakistan
This study aimed to determine the molecular prevalence and associated risk factors of theileriosis in sheep from Balochistan, Pakistan. For this...
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Integrated analysis of tumor-associated macrophages and M2 macrophages in CRC: unraveling molecular heterogeneity and develo** a novel risk signature
BackgroundEmerging investigations have increasingly highlighted the critical role of tumor-associated macrophages (TAMs) and M2 macrophages in cancer...
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Profiling of Circulating Gene Expression Reveals Molecular Signatures Associated with Intracranial Aneurysm Rupture Risk
BackgroundFollowing detection, rupture risk assessment for intracranial aneurysms (IAs) is critical. Towards molecular prognostics, we hypothesized...
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Risk factors and molecular epidemiology of fecal carriage of carbapenem resistant Enterobacteriaceae in patients with liver disease
BackgroundCarbapenem resistant Enterobacteriaceae (CRE) colonization is a risk factor for CRE infection. CRE infection results in an increase in...
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Molecular Mechanisms of Oncogenesis
Oncogenesis is the process of transformation of normal cells into malignant cells. It is often initiated by a variety of exogenous environmental and...
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Microscopic and molecular prevalence and associated risk factors with Toxocara and Blastocystis infection in dogs and cats in Mitidja, Algeria
Domestic dogs and cats can serve as a source of environmental contamination with Toxocara spp. and Blastocystis spp., and this represents a neglected...
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Epidemiology of rumen fluke infection in selected buffalo farms in perak, malaysia: prevalence, molecular species identification, and associated risk factors
Rumen flukes cause heavy economic losses in the ruminant industry worldwide, especially in tropical and subtropical countries. This study estimated...
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Exposure to Organochlorine Pesticides and Female Breast Cancer Risk According to Molecular Receptors Expression: a Systematic Review and Meta-analysis of Epidemiological Evidence
Purpose of ReviewOrganochlorine pesticides (OCP) have been proposed as potential mammary carcinogens since they interact with steroid signaling...
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Molecular Pathways and Animal Models of Arrhythmias
Arrhythmias account for over 300,000 annual deaths in the United States, and approximately half of all deaths are associated with heart disease....
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Translational Molecular Imaging Tool of Vulnerable Carotid Plaque: Evaluate Effects of Statin Therapy on Plaque Inflammation and American Heart Association–Defined Risk Levels in Cuff-Implanted Apolipoprotein E–Deficient Mice
Identification of high-risk carotid plaques in asymptomatic patients remains a challenging but crucial step in stroke prevention. The challenge is to...
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RNA sequencing-based single sample predictors of molecular subtype and risk of recurrence for clinical assessment of early-stage breast cancer
Multigene assays for molecular subtypes and biomarkers can aid management of early invasive breast cancer. Using RNA-sequencing we aimed to develop...
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Molecular Insights and Risk Factors Associated with Small and Non-small Cell Lung Cancer
With approximately two million new cases and 1.76 million deaths annually, lung cancer is one of the most commonly found malignancies and the main...
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Diagnosis of Echinococciasis: Parasitological, Immunological, and Molecular Tools
Echinococcosis is a serious zoonotic disease caused by the larvae of several Echinococcus species forming a hydatid cyst, which can parasitize humans...
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Molecular Profiling and Personalized Medicine in Drug-Resistant Breast Cancer
The utilization of molecular profiling techniques and personalized medicine approaches in the management of breast cancer is driven by molecular...