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Spatially resolved in vivo imaging of inflammation-associated mRNA via enzymatic fluorescence amplification in a molecular beacon
The in vivo optical imaging of RNA biomarkers of inflammation is hindered by low signal-to-background ratios, owing to non-specific signal...
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Advancements in Rapid and Affordable Diagnostic Testing for Respiratory Infectious Diseases: Evaluation of Aptamer Beacon Technology for Rapid and Sensitive Detection of SAR-CoV-2 in Breath Condensate
The demand for rapid and efficient diagnostic point-of-care tests for respiratory infectious diseases has become increasingly critical in the current...
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A phase II study of daily encorafenib in combination with biweekly cetuximab in patients with BRAF V600E mutated metastatic colorectal cancer: the NEW BEACON study
BackgroundPatients with BRAF V600E mutated metastatic colorectal cancer (mCRC) have a poor prognosis. The introduction of BRAF targeted therapy with...
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Unraveling the Potential of EphA4: A Breakthrough Target and Beacon of Hope for Neurological Diseases
Erythropoietin-producing hepatocellular carcinoma A4 (EphA4) is a transmembrane receptor protein which is a part of the most prominent family of...
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Molecular dynamics exploration of Lupenone: therapeutic implications for glioblastoma multiforme and alzheimer's amyloid beta pathogenesis
Neuro-oncological and neurodegenerative disorders, represented paradigmatically by glioblastoma and Alzheimer's disease, respectively, persist as...
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Molecular Methods for Detection of Βeta-Lactamases
Gram-negative bacterial infections are a substantial cause of health care associated morbidity and mortality among patients. β-lactam antibiotics are...
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Intramolecular Interactions in the Fluorophore–Quencher System in Linear and Hairpin Probes for Real-Time PCR
AbstractThe hairpin probe is characterized by a higher fluorescence quenching efficiency as compared with the linear one under the conditions of...
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Findings from precision oncology in the clinic: rare, novel variants are a significant contributor to scaling molecular diagnostics
BackgroundNext generation sequencing for oncology patient management is now routine in clinical pathology laboratories. Although wet lab, sequencing...
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Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance
Cancer is a complex disease displaying a variety of cell states and phenotypes. This diversity, known as cancer cell plasticity, confers cancer cells...
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NEXUS trial: a multicenter phase II clinical study evaluating the efficacy and safety of the perioperative use of encorafenib, binimetinib, and cetuximab in patients with previously untreated surgically resectable BRAF V600E mutant colorectal oligometastases
BackgroundThe optimal treatment strategy for resectable BRAF V600E mutant colorectal oligometastases (CRM) has not been established due to the...
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Nucleic Acid Amplification and Molecular Diagnostic Techniques in the Detection of ESKAPE Bacterial Pathogens
The word ESKAPE denotes a particular group of microbial species viz., Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumonia,...
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Exosome-mediated secretion of miR-127-3p regulated by RAB27A accelerates metastasis in renal cell carcinoma
BackgroundThe exosome-mediated extracellular secretion of miRNAs occurs in many cancers, and RAB27A is a potent regulator of exosome secretion. For...
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A Journey in Science: Molecular vaccines for global child health in troubled times of anti-science
My scientific life in translational medicine runs in two parallel, yet often converging paths. The first, is four-decade-long commitment to develop...
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Extension in the approaches to treat cancer through siRNA system: a beacon of hope in cancer therapy
Along with the evolutionary breakthrough of RNA interference and the applicability for gene knockdown, a subsequent development in siRNA-based...
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Purification and biochemical characterization of Msi3, an essential Hsp110 molecular chaperone in Candida albicans
Hsp110s are unique and essential molecular chaperones in the eukaryotic cytosol. They play important roles in maintaining cellular protein...
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Molecular changes in adipocyte-derived stem cells during their interplay with cervical cancer cells
PurposeObesity is as an important risk factor and has been associated with a worse prognosis in at least 13 distinct tumor types. This is partially...
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Claudin18.2 is a novel molecular biomarker for tumor-targeted immunotherapy
The claudin18.2 (CLDN18.2) protein, an isoform of claudin18, a member of the tight junction protein family, is a highly selective biomarker with...
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Capture and Concentration of Circulating Cancer-Associated Extracellular Vesicles
Extracellular vesicles (EVs) are a category of nanoscale membrane-bound bodies secreted by nearly every cell in the body and found in nearly all...
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Medical viruses: diagnostic techniques
The recent epidemics and pandemics caused by different viruses such as SARS-CoV-2, monkey pox, H1N1, ebola virus etc. have been a cause of mass...
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Drug Resistance in Tuberculosis: Mechanisms, Diagnosis, New Responses, and the Need for an Integrated Approach
Despite the global efforts done in recent decades, tuberculosis (TB)’s impact on global public healthPublic health remains substantial. In recent...