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Curcuminoids and Sesquiterpenoids from Curcuma longa Rhizomes: Can They Be the Cure for Neurodegenerative Disorders?
Curcuma longa L. (turmeric) belongs to the same family as ginger (Zingiberaceae) and is native to Southeast Asia (India and China); it is a fragrant...
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Laboratory evaluation of the contact irritancy of a clothianidin solo formulation vs. clothianidin-deltamethrin mixture formulations for indoor residual spraying against pyrethroid-resistant Anopheles gambiae sensu lato
BackgroundClothianidin-based indoor residual spraying (IRS) formulations have become available for malaria control as either solo formulations of...
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Homology-directed repair of an MYBPC3 gene mutation in a rat model of hypertrophic cardiomyopathy
Variants in myosin-binding protein C3 ( MYBPC3 ) gene are a main cause of hypertrophic cardiomyopathy (HCM), accounting for 30% to 40% of the total...
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A macrophage-cell model of HIV latency reveals the unusual importance of the bromodomain axis
BackgroundAlthough macrophages are now recognized as an essential part of the HIV latent reservoir, whether and how viral latency is established and...
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Microfluidic model of the alternative vasculature in neuroblastoma
Neuroblastoma (NB) is a highly vascularized pediatric tumor arising from undifferentiated neural crest cells early in life, exhibiting both...
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Neuroprotective Effects of Metformin Through AMPK Activation in a Neurotoxin-Based Model of Cerebellar Ataxia
Cerebellar ataxia is a heterogeneous group of neural disorders clinically characterized by cerebellar dysfunction. The diagnosis of patients with...
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A Preliminary Step Towards a Physical Surrogate of the Human Calvarium to Model Fracture
A surrogate model of the human calvarium can be used to assess skull-fracture-related head injuries without continuously requiring post-mortem human...
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The cure from within? a review of the microbiome and diet in melanoma
Therapy for cutaneous melanoma, the deadliest of the skin cancers, is inextricably linked to the immune system. Once thought impossible, cures for...
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COVID-19-Related manuscripts: lag from preprint to publication
ObjectivePreprints have had a prominent role in the swift scientific response to COVID-19. Two years into the pandemic, we investigated how much...
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Hypoxic 3D Tumor Model for Evaluating of CAR-T Cell Therapy In Vitro
Solid tumors contain abnormal physical and biochemical barriers that hinder chimeric antigen receptor (CAR) T cell therapies. However, there is a...
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Heat shock protein 90 (Hsp90) inhibitor STA-9090 (Ganetespib) ameliorates inflammation in a mouse model of atopic dermatitis
Molecular chaperones belonging to the heat shock protein 90 (Hsp90) family are implicated in inflammatory processes and described as potential novel...
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Three-Dimensional Human Brain Organoids to Model HIV-1 Neuropathogenesis
Studying neurological diseases have long been hampered by the lack of physiologically relevant models to resemble the complex human brain and the...
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QbD Based Formulation Development and Optimisation of Ozenoxacin Topical Nano-Emulgel and Efficacy Evaluation Using Impetigo Mice Model
To formulate and optimize Ozenoxacin nano-emulsion using Quality by Design (QbD) concept by means of Box–Behnken Design (BBD) and converting it to a...
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The ex vivo perfused mouse adrenal gland—a new model to study aldosterone secretion
Aldosterone is a steroid hormone that is important for maintaining the volume and ionic composition of extracellular fluids and is produced in the...
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Fecal Microbiota Transplantation as Emerging Treatment in European Countries 2.0
Clostridioides difficile infection (CDI) is one of the most common healthcare-associated infections and one of the leading causes of morbidity and...
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MiR-184 Mediated the Expression of ZNF865 in Exosome to Promote Procession in the PD Model
Exosomes are nanoscale small vesicles (EVs) secreted by cells that carry important bio information, including proteins, miRNAs, and more. Exosome...
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Systemic Delivery of a Monoclonal Antibody to Immunologically Block Myostatin in the A17 Mouse Model of OPMD
Oculopharyngeal muscular dystrophy (OPMD) is a late-onset rare muscle disease affecting approximately 1 in 80,000 individuals worldwide. However, it...
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The curative and mechanistic acumen of curcuminoids formulations against haloperidol induced Parkinson’s disease animal model
Parkinson’s disease (PD) is slowly develo** neurodegenerative disorder associated with gradual decline in cerebration and laboriousness to perform...
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Protective effects of curcumin and Ginkgo biloba extract combination on a new model of Alzheimer’s disease
Alzheimer’s disease (AD) is one of the most prevalent neurodegenerative illnesses, and yet, no workable treatments have been discovered to prevent or...
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Anti-inflammatory Action of BT75, a Novel RARα Agonist, in Cultured Microglia and in an Experimental Mouse Model of Alzheimer’s Disease
BT75, a boron-containing retinoid, is a novel retinoic acid receptor (RAR)α agonist synthesized by our group. Previous studies indicated that...
