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Mixing
Mixing is an important process in the pharmaceutical industry; it ensures the uniformity of composition among all components by blending them; it is...
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Use of Resonant Acoustic Mixing Technology for Ultra-Low-Dose Blending in a Single-Step Mixing Process
PurposeTo evaluate the use of resonant acoustic mixing (RAM) technology for homogenous blending of a morphologically challenging model API in...
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An Understanding of the Relationship Between Mixing Performance and Power Consumption in a High-Shear Wet Granulation Pre-mixing
IntroductionHigh-shear wet granulation (HSWG) is most commonly used in the pharmaceutical industry, with the advantages of being fully enclosed,...
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Mixing and Filtration
Mixing and filtration are crucial in the pharmaceutical industry. Poor mixing can result in product failure, while sterile filtration is the only...
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Mixing
Pharmaceutical processes that need mixing include dissolution of solids in liquids, mixing of liquid with liquid, dispersion of solid or liquid in...
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Assessment of Resonant Acoustic Mixing for Low-Dose Pharmaceutical Powder Blends
Obtaining a homogeneous low-dose pharmaceutical powder blend without multi-step processing remains a challenge. One promising technology to address...
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Scale-Up of Liquid Mixing Process
To meet the growing demands of production and reduce costs, it is necessary to increase the scale of production. However, transferring the lab-scale...
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Reduced Fine API Agglomeration After Dry Coating for Enhanced Blend Uniformity and Processability of Low Drug Loaded Blends
PurposeThe impact of dry coating on reduced API agglomeration remains underexplored. Therefore, this work quantified fine cohesive API agglomeration...
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Development of Inline Near-Infrared Spectroscopy Method for Real-Time Monitoring of Blend Uniformity of Direct Compression and Granulation-Based Products at Commercial Scales
Blending is a critical intermediate unit operation for all solid oral formulations. For blend uniformity testing, API content in the blend must be...
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Streamlining of the Powder Mixing Process based on a Segregation Test
In direct compression of tablets, it is crucial to maintain content uniformity within acceptable margins, especially in formulations with low drug...
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Dry Powder Mixing Is Feasible in Continuous Twin Screw Extruder: Towards Lean Extrusion Process for Oral Solid Dosage Manufacturing
Using discrete element method (DEM) modeling and near-infrared (NIR) spectroscopy, the feasibility of powder mixing in the initial pre-melting zones...
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Machine Learning-Enabled NIR Spectroscopy in Assessing Powder Blend Uniformity: Clear-Up Disparities and Biases Induced by Physical Artefacts
NIR spectroscopy is a non-destructive characterization tool for the blend uniformity (BU) assessment. However, NIR spectra of powder blends often...
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Spherical Agglomerates of Lactose Reduce Segregation in Powder Blends and Improve Uniformity of Tablet Content at High Drug Loads
We report here on improved uniformity of blends of micronised active pharmaceutical ingredients (APIs) using addition of spherical agglomerates of...
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Evaluation and Monitoring of the API Content of a Portable Near Infrared Instrument Combined with Chemometrics Based on Fluidized Bed Mixing Process
PurposeWith the promulgation of industry guidelines, near infrared spectroscopy (NIRS) monitoring the uniformity of solid oral preparations has...
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Establishment of a simple method to evaluate mixing times in a plastic bag photobioreactor using image processing based on freeware tools
ObjectiveAccurate determination of the mixing time in bioreactors is essential for the optimization of the productivity of bioprocesses. The aim of...
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Novel Coating Uniformity Models for Tablet Pan Coaters
Novel mathematical models were developed to predict inter-tablet coating uniformity in terms of coefficients of variation ( CV ) and acceptance values (
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Enhancement of Fingolimod Content Uniformity as a Low-Dose Drug with Narrow Therapeutic Index Using Liquisolid Technique
PurposeAcceptable content uniformity is one of the major challenges in industrial pharmacy especially in low-dose drugs with narrow therapeutic...
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Impact of Different Mixing Methods on the Performance of Suspension-Based Transdermal Delivery Systems
Suspension-based matrix transdermal delivery systems (TDSs) are specialized systems that maintain a continuous driving force for drug delivery over...
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Direct Tableting on a Continuous Manufacturing Line—Impact of Mixing Parameters, Material Densities, and Drug Load on Subsequent Process Parameters and Tablet Quality
The continuous manufacturing (CM) of solid oral dosage forms has received increased attention in recent years and has become a leading technology in...
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NIR Spectroscopy as an Online PAT Tool for a Narrow Therapeutic Index Drug: Toward a Platform Approach Across Lab and Pilot Scales for Development of a Powder Blending Monitoring Method and Endpoint Determination
An online near-infrared (NIR) spectroscopy platform system for real-time powder blending monitoring and blend endpoint determination was tested for...
