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The movement of mitochondria in breast cancer: internal motility and intercellular transfer of mitochondria
As a major energy source for cells, mitochondria are involved in cell growth and proliferation, as well as migration, cell fate decisions, and many...
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Socialized mitochondria: mitonuclear crosstalk in stress
Traditionally, mitochondria are considered sites of energy production. However, recent studies have suggested that mitochondria are signaling...
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Mitochondria as secretory organelles and therapeutic cargos
Mitochondria have been primarily considered intracellular organelles that are responsible for generating energy for cell survival. However,...
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Assessment of Bioenergetics in BAT Mitochondria
High-resolution respirometry is commonly used to quantify mitochondrial respiratory rates. In the respirometry chamber, a change in oxygen...
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Extracellular release in the quality control of the mammalian mitochondria
Mammalian cells release a wealth of materials to their surroundings. Emerging data suggest these materials can even be mitochondria with perturbed...
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Endothelial Mitochondria-Associated Membranes (MAMs) Isolation by Percoll Step Gradients
Mitochondria-associated membranes (MAMs) are regions where the endoplasmic reticulum (ER) interacts with mitochondria and regulate lipid trafficking,...
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Focusing on mitochondria in the brain: from biology to therapeutics
Mitochondria have multiple functions such as supplying energy, regulating the redox status, and producing proteins encoded by an independent genome....
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Biodistribution of Intravenously Transplanted Mitochondria Conjugated with Graphene Quantum Dots in Diabetic Rats
Mitochondria transplantation has emerged as a successful therapeutic modality to treat several degenerative diseases. However, the biodistribution of...
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Mitochondria Modulating Therapeutic Approaches in the Management of Huntington’s Disease
Purpose of ReviewMitochondrial dysfunctions are considered epistatic to cellular malfunctions during advancement of neurodegenerative disorders,...
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Mitochondria-Targeted Antioxidants and Cancer
Antioxidant therapy in cancer is gaining momentum after witnessing a striking success of mitochondria-targeted antioxidants in oxidative...
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Calcium signaling from sarcoplasmic reticulum and mitochondria contact sites in acute myocardial infarction
Acute myocardial infarction (AMI) is a serious condition that occurs when part of the heart is subjected to ischemia episodes, following partial or...
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Purification of functional mouse skeletal muscle mitochondria using percoll density gradient centrifugation
ObjectiveOur goal was to isolate purified mitochondria from mouse skeletal muscle using a Percoll density gradient and to assess bioenergetic...
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Shrimp miR-965 transfers tumoricidal mitochondria
BackgroundMicro RNA of Marsupenaeus japonicas has been known to promote apoptosis of tumor cells. However, the detailed mechanisms are not well...
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Mitochondria-associated programmed cell death as a therapeutic target for age-related disease
Mitochondria, ubiquitous double-membrane-bound organelles, regulate energy production, support cellular activities, harbor metabolic pathways, and,...
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Interaction between mitochondria and microbiota modulating cellular metabolism in inflammatory bowel disease
Inflammatory bowel disease (IBD) is a prototypic complex disease in the gastrointestinal tract that has been increasing in incidence and prevalence...
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Relevance of the endoplasmic reticulum-mitochondria axis in cancer diagnosis and therapy
Dynamic interactions between organelles are responsible for a variety of intercellular functions, and the endoplasmic reticulum (ER)–mitochondrial...
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Proteomic analysis of mitochondria associated membranes in renal ischemic reperfusion injury
BackgroundThe mitochondria and endoplasmic reticulum (ER) communicate via contact sites known as mitochondria associated membranes (MAMs). Many...
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Engineered inhaled nanocatalytic therapy for ischemic cerebrovascular disease by inducing autophagy of abnormal mitochondria
Mitochondrial dysfunction and subsequent accumulation of reactive oxygen species (ROS) are key contributors to the pathology of ischemic...
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Oxidative Dyshomeostasis in the Mitochondria
The etiology of cancer is profoundly associated with variable degrees of oxidative stress in a tissue. Mitochondria, being the paramount seat of...
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Mitochondria-derived vesicles and their potential roles in kidney stone disease
Recent evidence has shown significant roles of mitochondria-derived vesicles (MDVs) in mitochondrial quality control (MQC) system. Under mild stress...
