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Antidepressant-like effect of endogenous SO2 on depression caused by chronic unpredictable mild stress
Sulfur dioxide (SO 2 ) is a toxic gas with harmful effects on various organs. However, recent studies have confirmed the protective effect of SO 2 on...
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The beneficial effects of vortioxetine on BDNF, CREB, S100B, β amyloid, and glutamate NR2b receptors in chronic unpredictable mild stress model of depression
BackgroundDepression, one of the most significant mental disorders, is still poorly understood in terms of its pathogenetic mechanisms despite its...
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Plasma metabolomics reveals the intervention mechanism of different types of exercise on chronic unpredictable mild stress-induced depression rat model
ObjectiveTo study the effects of different types of exercise on the plasma metabolomics of chronic unpredictable mild stress (CUMS)-induced depressed...
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Medicarpin Improves Depressive-Like Behaviors in a Chronic Unpredictable Mild Stress-Induced Mouse Model of Depression by Upregulating Liver X Receptor β Expression in the Amygdala
Presently, the regulatory mechanism underlying depression is indistinct, and almost 50% of depression sufferers undergo no apparent effects during...
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Chronic mild stress paradigm as a rat model of depression: facts, artifacts, and future perspectives
RationaleThe chronic mild stress (CMS) paradigm was first described almost 40 years ago and has become a widely used model in the search for...
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Intranasal administration of interleukin-4 ameliorates depression-like behavior and biochemical alterations in mouse submitted to the chronic unpredictable mild stress: modulation of neuroinflammation and oxidative stress
Physical and psychological stress modulates the hypothalamic pituitary adrenal (HPA) axis, and the redox and inflammatory systems. Impairments in...
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Estimating attrition in mild-to-moderate Alzheimer’s disease and mild cognitive impairment clinical trials
BackgroundParticipant retention is a key factor that affects clinical trial integrity. Trial protocols estimate attrition as a function of sample...
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Does Sertraline Affect Hypothalamic Food Intake Peptides in the Rat Experimental Model of Chronic Mild Stress-Induced Depression?
Depression is a chronic, recurrent and life-threatening disease affecting approximately 15% of the world population. Depression is responsible for...
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Loureirin C and Xanthoceraside Attenuate Depression-Like Behaviors and Expression of Interleukin-17 in the Prefrontal Cortex Induced by Chronic Unpredictable Mild Stress in Mice
Major depressive disorder (MDD) is the most prevalent and serious psychiatric disease involving inflammation. Loureirin C and Xanthoceraside are...
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Methane-rich saline ameliorates depressive-like behaviors during chronic unpredictable mild stress (CUMS)
Depression, considered the most prevalent neuropsychiatric disorder, is multifactorial and complex. Oxidative stress and inflammation significantly...
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Resting-state EEG datasets of adolescents with mild, minimal, and moderate depression
ObjectivesTo measure depressive severity of 85 Thai adolescents by using the the Beck Depression Inventory-II and the Patient Health Questionnaire-9...
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Hypothalamic Gene Expression in a Rat Model of Chronic Unpredictable Mild Stress Treated with Electroacupuncture
Depression is characterized by the loss of pleasure and a depressed mood, and it is a common mental disorder in the twenty-first century. Multiple...
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Elevated Level of Small Extracellular Vesicles in the Serum of Patients With Depression, Epilepsy and Epilepsy with Depression
Abstract —Characteristics of small extracellular vesicles (sEVs) and sEVs composition are far from being well-studied for now, especially in the...
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Stress, depression, and risk of dementia – a cohort study in the total population between 18 and 65 years old in Region Stockholm
BackgroundChronic stress and depression are potential risk factors for mild cognitive impairment and dementia, including Alzheimer disease. The aim...
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Artificial Intelligence (AI) and Its Role in Depression
Depression is a common illness that affects millions of people worldwide each year. Three hundred million people each year suffer greatly, as it can...
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Multi-scale modeling to investigate the effects of transcranial magnetic stimulation on morphologically-realistic neuron with depression
Transcranial magnetic stimulation (TMS) is a non-invasive neuromodulation technique to activate or inhibit the activity of neurons, and thereby...
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Ketamine abrogates sensorimotor deficits and cytokine dysregulation in a chronic unpredictable mild stress model of depression
Major depressive disorder (MDD) is a serious mental disorder with influence across the functional systems of the body. The pathogenesis of MDD has...
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Simvastatin ameliorates synaptic plasticity impairment in chronic mild stress-induced depressed mice by modulating hippocampal NMDA receptor
BackgroundIn our previous study, we showed simvastatin exerts an antidepressant effect and inhibits neuroinflammation. Given the role of synaptic...
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EEG Correlates of Suicidal Intent in Patients with Depression With and Without COVID-19
Objectives . To seek EEG correlates of suicidal intent in young patients with depression with and without COVID-19. Materials and methods . We examined...
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Atractylenolide I Suppresses A1 Astrocyte Activation to Improve Depression in Mice
This work aimed to investigate the role of atractylenolide I (ATR) in resisting depression and its mechanism of action. The mouse model of depression...
