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Estimating attrition in mild-to-moderate Alzheimer’s disease and mild cognitive impairment clinical trials
BackgroundParticipant retention is a key factor that affects clinical trial integrity. Trial protocols estimate attrition as a function of sample...
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Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer’s disease: a randomized, controlled clinical trial
BackgroundEvidence links lifestyle factors with Alzheimer’s disease (AD). We report the first randomized, controlled clinical trial to determine if...
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Systematic review: fluid biomarkers and machine learning methods to improve the diagnosis from mild cognitive impairment to Alzheimer’s disease
Mild cognitive impairment (MCI) is often considered an early stage of dementia, with estimated rates of progression to dementia up to 80–90% after...
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Molecular Imaging of Neuroinflammation in Alzheimer’s Disease and Mild Cognitive Impairment
Alzheimer’s disease (AD) is the most prevalent neurocognitive disorder. Due to the ineffectiveness of treatments targeting the amyloid cascade,...
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Differences between Alzheimer’s disease and mild cognitive impairment using brain networks from magnetic resonance texture analysis
Several studies have aimed at identifying biomarkers in the initial phases of Alzheimer’s disease (AD). Conversely, texture features, such as those...
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Hippocampal subfield volumes in mild cognitive impairment and alzheimer’s disease: a systematic review and meta-analysis
The hippocampus is a complex structure that consists of several subfields with distinct and specialized functions. Although numerous studies have...
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Neural biomarker diagnosis and prediction to mild cognitive impairment and Alzheimer’s disease using EEG technology
BackgroundElectroencephalogram (EEG) has emerged as a non-invasive tool to detect the aberrant neuronal activity related to different stages of...
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Optimizing detection of Alzheimer’s disease in mild cognitive impairment: a 4-year biomarker study of mild behavioral impairment in ADNI and MEMENTO
BackgroundDisease-modifying drug use necessitates better Alzheimer disease (AD) detection. Mild cognitive impairment (MCI) leverages cognitive...
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Prediction of conversion from mild cognitive impairment to Alzheimer’s disease and simultaneous feature selection and grou** using Medicaid claim data
BackgroundDue to the heterogeneity among patients with Mild Cognitive Impairment (MCI), it is critical to predict their risk of converting to...
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The cognitive effect of non-invasive brain stimulation combined with cognitive training in Alzheimer’s disease and mild cognitive impairment: a systematic review and meta-analysis
BackgroundNon-invasive brain stimulation (NIBS) combined with cognitive training (CT) may have shown some prospects on improving cognitive function...
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CSF neurochemical profile and cognitive changes in Parkinson’s disease with mild cognitive impairment
Pathophysiological substrate(s) and progression of Parkinson’s disease (PD) with mild cognitive impairment (PD-MCI) are still matter of debate....
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Blood and CSF chemokines in Alzheimer’s disease and mild cognitive impairment: a systematic review and meta-analysis
ObjectiveChemokines, which are chemotactic inflammatory mediators involved in controlling the migration and residence of all immune cells, are...
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Convergent Neuroimaging and Molecular Signatures in Mild Cognitive Impairment and Alzheimer’s Disease: A Data-Driven Meta-Analysis with N = 3,118
The current study aimed to evaluate the susceptibility to regional brain atrophy and its biological mechanism in Alzheimer’s disease (AD). We...
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Comparing a pre-defined versus deep learning approach for extracting brain atrophy patterns to predict cognitive decline due to Alzheimer’s disease in patients with mild cognitive symptoms
BackgroundPredicting future Alzheimer’s disease (AD)-related cognitive decline among individuals with subjective cognitive decline (SCD) or mild...
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Clinical validity of the Italian adaptation of the Uniform Data Set Neuropsychological Test Battery (I-UDSNB) in Mild Cognitive Impairment and Alzheimer’s Disease
BackgroundThe identification and staging of Alzheimer’s Disease (AD) represent a challenge, especially in the prodromal stage of Mild Cognitive...
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Digital Clock and Recall is superior to the Mini-Mental State Examination for the detection of mild cognitive impairment and mild dementia
BackgroundDisease-modifying treatments for Alzheimer’s disease highlight the need for early detection of cognitive decline. However, at present, most...
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Atrophy asymmetry in hippocampal subfields in patients with Alzheimer’s disease and mild cognitive impairment
Volumetric analysis of hippocampal subfields and their asymmetry assessment recently has been useful biomarkers in neuroscience. In this study,...
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Profiles of subgingival microbiomes and gingival crevicular metabolic signatures in patients with amnestic mild cognitive impairment and Alzheimer’s disease
BackgroundThe relationship between periodontitis and Alzheimer’s disease (AD) has attracted more attention recently, whereas profiles of subgingival...
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Time-Based and Event-Based Prospective Memory in Mild Cognitive Impairment and Alzheimer’s Disease Patients: A Systematic Review and Meta-analysis
Prospective memory (PM) is the ability to remember to perform planned actions in a future moment and it is of fundamental importance for an...
